Specific toxic effects of complex extracts from gas phase and six fractions of air particulate matter from localities with different pollution sources

LANDLOVÁ, Linda, Jiří NOVÁK, Pavel ČUPR, Jana KLÁNOVÁ, Giesy JOHN a Klára HILSCHEROVÁ. Specific toxic effects of complex extracts from gas phase and six fractions of air particulate matter from localities with different pollution sources. In Nucleation and Atmospheric Aerosols. Praha: Institute of Chemical Process Fundamentals ASCR, 2009, s. 960-964, 4 s. ISBN 978-80-02-12161-9.

Základní údaje

• Originální název: Specific toxic effects of complex extracts from gas phase and six fractions of air particulate matter from localities with different pollution sources
• Název česky: Specifické toxické efekty komplexních extraktů vzorků plynné frakce vzduchu a šesti velikostních frakcí vzdušného aerosolu z lokalit s různými zdroji znečištění
• Název anglicky: Specific toxic effects of complex extracts from gas phase and six fractions of air particulate matter from localities with different pollution sources
• Autoři: LANDLOVÁ, Linda, Jiří NOVÁK, Pavel ČUPR, Jana KLÁNOVÁ, Giesy JOHN a Klára HILSCHEROVÁ.
• Vydání: Praha, Nucleation and Atmospheric Aerosols, od s. 960-964, 4 s. 2009.
• Nakladatel: Institute of Chemical Process Fundamentals ASCR

Další údaje

• Typ výsledku: Stať ve sborníku
• Obor: 10511 Environmental sciences
• Utajení: není předmětem státního či obchodního tajemství
• Organizační jednotka: Přírodovědecká fakulta
• ISBN: 978-80-02-12161-9
• Klíčová slova anglicky: air particulate matter, size fractions, dioxin-like, estrogenicity, antiandrogenicity

Anotace

Ambient air is contaminated by very complex mixture of contaminants and routine chemical analyses focus only on limited number of chosen indicator compounds. However, as it was shown previously, the non-detected compounds could produce significant biological effects. The air pollution has been associated mainly with lung, hearth diseases and genotoxic effects. Recent studies however indicate that the air pollutants could act also as endocrine disruptors in vitro as well as in vivo. In our study, we assessed genotoxicity, dioxin-like activity, anti/estrogenicity and anti/androgenicity of extracts from gas phase of air and six breathable size fractions of air particulate matter in vitro. The air samples have been collected at six localities that differed in type of contamination coming from industrial and combustions sources. We observed significant genotoxic, dioxin-like and antiestrogenic potency of the extracts from particulate air matter. This potency increased with decreasing diameter of the particles. Interestingly, extracts from gas phase of the air samples showed, besides similar effects produced by the particulate matter extracts, also significant antiandrogenicity. The results suggest that, besides genotoxicity, also other specific effects should be included in risk assessment to better describe overall toxic effects of the complex environmental mixtures of pollutants including interactions of their effects.

Anotace česky

Ambient air is contaminated by very complex mixture of contaminants and routine chemical analyses focus only on limited number of chosen indicator compounds. However, as it was shown previously, the non-detected compounds could produce significant biological effects. The air pollution has been associated mainly with lung, hearth diseases and genotoxic effects. Recent studies however indicate that the air pollutants could act also as endocrine disruptors in vitro as well as in vivo. In our study, we assessed genotoxicity, dioxin-like activity, anti/estrogenicity and anti/androgenicity of extracts from gas phase of air and six breathable size fractions of air particulate matter in vitro. The air samples have been collected at six localities that differed in type of contamination coming from industrial and combustions sources. We observed significant genotoxic, dioxin-like and antiestrogenic potency of the extracts from particulate air matter. This potency increased with decreasing diameter of the particles. Interestingly, extracts from gas phase of the air samples showed, besides similar effects produced by the particulate matter extracts, also significant antiandrogenicity. The results suggest that, besides genotoxicity, also other specific effects should be included in risk assessment to better describe overall toxic effects of the complex environmental mixtures of pollutants including interactions of their effects.

Anotace anglicky

Ambient air is contaminated by very complex mixture of contaminants and routine chemical analyses focus only on limited number of chosen indicator compounds. However, as it was shown previously, the non-detected compounds could produce significant biological effects. The air pollution has been associated mainly with lung, hearth diseases and genotoxic effects. Recent studies however indicate that the air pollutants could act also as endocrine disruptors in vitro as well as in vivo. In our study, we assessed genotoxicity, dioxin-like activity, anti/estrogenicity and anti/androgenicity of extracts from gas phase of air and six breathable size fractions of air particulate matter in vitro. The air samples have been collected at six localities that differed in type of contamination coming from industrial and combustions sources. We observed significant genotoxic, dioxin-like and antiestrogenic potency of the extracts from particulate air matter. This potency increased with decreasing diameter of the particles. Interestingly, extracts from gas phase of the air samples showed, besides similar effects produced by the particulate matter extracts, also significant antiandrogenicity. The results suggest that, besides genotoxicity, also other specific effects should be included in risk assessment to better describe overall toxic effects of the complex environmental mixtures of pollutants including interactions of their effects.

Návaznosti

• MSM0021622412, záměr: Název: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Akronym: INCHEMBIOL)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální , regionální a lokální úrovni

• SP/1A3/29/07, projekt VaV: Název: Komplexní charakterizace prachových frakci ve volném ovzduší (AirToxPM) (Akronym: AirToxPM)

Investor: Ministerstvo životního prostředí ČR, Komplexní charakterizace prachových frakcí ve volném ovzduší

• 2B08036, projekt VaV: Název: Nové molekulárně biologické a biochemické metody pro monitoring estrogenů a dalších chemických endokrinních disruptorů (Akronym: ENVISCREEN)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Nové molekulárně biologické a biochemické metody pro monitoring estrogenů a dalších chemických endokrinních disruptorů