Whole genome sequencing of pathogenic and nonpathogenic
treponemes: comparison of syphilis and yaws strains with T.
paraluiscuniculi.

D 2009

Whole genome sequencing of pathogenic and nonpathogenic treponemes: comparison of syphilis and yaws strains with T. paraluiscuniculi.

ŠMAJS, David; Marie ZOBANÍKOVÁ; Darina ČEJKOVÁ; Petra MATĚJKOVÁ POSPÍŠILOVÁ; Michal STROUHAL et al.

Základní údaje

Originální název

Whole genome sequencing of pathogenic and nonpathogenic treponemes: comparison of syphilis and yaws strains with T. paraluiscuniculi.

Autoři

ŠMAJS, David; Marie ZOBANÍKOVÁ; Darina ČEJKOVÁ; Petra MATĚJKOVÁ POSPÍŠILOVÁ; Michal STROUHAL a Weinstock GEORGE M.

Vydání

Neuveden, Clinical Microbiology and Infection, Volume 15, Issue s4, Abstracts of the 19th ECCMID, P1329, s. 368-368, 2009

Nakladatel

European Society of Clinical Microbiology and Infectious Diseases

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

Genetika a molekulární biologie

Stát vydavatele

Finsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.014

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/09:00029916

Organizační jednotka

Lékařská fakulta

ISSN

Klíčová slova česky

syfilis; yaws; Treponema pallidum subsp. pallidum; Treponema pallidum subsp pertenue; Treponema paraluiscuniculi

Klíčová slova anglicky

syphilis; yaws; Treponema pallidum subsp. pallidum; Treponema pallidum subsp pertenue; Treponema paraluiscuniculi

Změněno: 8. 4. 2010 14:23, prof. MUDr. David Šmajs, Ph.D.

Anotace

V originále

Treponema pallidum subsp. pallidum (TPA) is the causative agent of syphilis, T. pallidum ssp. pertenue (TPE) causes endemic treponematosis yaws, and T. paraluiscuniculi is not infectious to humans but causes venereal spirochetosis in rabbits. The genomes of TPE strain Samoa D and T. paraluiscuniculi strain Cuniculi A were sequenced using several whole-genome sequencing methods. Obtained whole genome sequences were compared to the published sequence of TPA strain Nichols. The genome size of TPA Nichols (1,138,006 bp), TPE Samoa D (1,139,299 bp) and T. paraluiscuniculi Cuniculi A (1,133,391 bp) and the overall gene order is similar in all investigated genomes. More than 50% of Nichols and Samoa D genes encode sequentially identical proteins whereas only 15% of those genes were found in the Cuniculi A and Samoa D genomes. Major sequence changes including frameshifts were found in 88 genes of the Cuniculi A genome when compared to the Nichols genome.

Návaznosti

GA310/07/0321, projekt VaV

Název: Komparativní genomové sekvencování patogenních treponem a transkriptomová analýza T. pallidum ssp. pallidum

Investor: Grantová agentura ČR, Komparativní genomové sekvencování patogenních treponem a transkriptomová analýza T. pallidum ssp. pallidum

MSM0021622415, záměr

Název: Molekulární podstata buněčných a tkáňových regulací

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární podstata buněčných a tkáňových regulací

NR8967, projekt VaV

Název: Molekulární typizace kmenů a izolátů Treponema pallidum subsp. pallidum: základ pro epidemiologickou a klinickou identifikaci jednotlivých kmenů

Investor: Ministerstvo zdravotnictví ČR, Molekulární typizace kmenů a izolátů Treponema pallidum subsp. Pallidum: základ pro epidemiologickou a klinickou identifikaci jednotlivých kmenů

Citovat

ŠMAJS, David; Marie ZOBANÍKOVÁ; Darina ČEJKOVÁ; Petra MATĚJKOVÁ POSPÍŠILOVÁ; Michal STROUHAL a Weinstock GEORGE M. Whole genome sequencing of pathogenic and nonpathogenic treponemes: comparison of syphilis and yaws strains with T. paraluiscuniculi. In Clinical Microbiology and Infection, Volume 15, Issue s4, Abstracts of the 19th ECCMID, P1329. Neuveden: European Society of Clinical Microbiology and Infectious Diseases, 2009, s. 368. ISSN 1198-743X.

@inproceedings{873303,
   author = {Šmajs, David and Zobaníková, Marie and Čejková, Darina and Matějková Pospíšilová, Petra and Strouhal, Michal and George M., Weinstock},
   address = {Neuveden},
   booktitle = {Clinical Microbiology and Infection, Volume 15, Issue s4, Abstracts of the 19th ECCMID, P1329},
   keywords = {syphilis; yaws; Treponema pallidum subsp. pallidum; Treponema pallidum subsp pertenue; Treponema paraluiscuniculi},
   language = {eng},
   location = {Neuveden},
   pages = {368-368},
   publisher = {European Society of Clinical Microbiology and Infectious Diseases},
   title = {Whole genome sequencing of pathogenic and nonpathogenic treponemes: comparison of syphilis and yaws strains with T. paraluiscuniculi.},
   url = {http://www3.interscience.wiley.com/cgi-bin/fulltext/122401282/PDFSTART},
   year = {2009}
}

TY  - CONF
ID  - 873303
AU  - Šmajs, David - Zobaníková, Marie - Čejková, Darina - Matějková Pospíšilová, Petra - Strouhal, Michal - George M., Weinstock
PY  - 2009
TI  - Whole genome sequencing of pathogenic and nonpathogenic treponemes: comparison of syphilis and yaws strains with T. paraluiscuniculi.
PB  - European Society of Clinical Microbiology and Infectious Diseases
CY  - Neuveden
KW  - syphilis
KW  - yaws
KW  - Treponema pallidum subsp. pallidum
KW  - Treponema pallidum subsp pertenue
KW  - Treponema paraluiscuniculi
UR  - http://www3.interscience.wiley.com/cgi-bin/fulltext/122401282/PDFSTART
N2  - Treponema pallidum subsp. pallidum (TPA) is the causative agent of syphilis, T. pallidum ssp. pertenue (TPE) causes endemic treponematosis yaws, and T. paraluiscuniculi is not infectious to humans but causes venereal spirochetosis in rabbits. The genomes of TPE strain Samoa D and T. paraluiscuniculi strain Cuniculi A were sequenced using several whole-genome sequencing methods. Obtained whole genome sequences were compared to the published sequence of TPA strain Nichols. The genome size of TPA Nichols (1,138,006 bp), TPE Samoa D (1,139,299 bp) and T. paraluiscuniculi Cuniculi A (1,133,391 bp) and the overall gene order is similar in all investigated genomes. More than 50% of Nichols and Samoa D genes encode sequentially identical proteins whereas only 15% of those genes were found in the Cuniculi A and Samoa D genomes. Major sequence changes including frameshifts were found in 88 genes of the Cuniculi A genome when compared to the Nichols genome.
ER  -

ŠMAJS, David; Marie ZOBANÍKOVÁ; Darina ČEJKOVÁ; Petra MATĚJKOVÁ POSPÍŠILOVÁ; Michal STROUHAL a Weinstock GEORGE M. Whole genome sequencing of pathogenic and nonpathogenic treponemes: comparison of syphilis and yaws strains with T. paraluiscuniculi. In \textit{Clinical Microbiology and Infection, Volume 15, Issue s4, Abstracts of the 19th ECCMID, P1329}. Neuveden: European Society of Clinical Microbiology and Infectious Diseases, 2009, s.~368. ISSN~1198-743X.

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