Long-term health outcome and mortality evaluation after
invasive coronary treatment using drug eluting stents with or
without the IVUS guidance. Randomized control trial. HOME DES
IVUS.

J 2010

Long-term health outcome and mortality evaluation after invasive coronary treatment using drug eluting stents with or without the IVUS guidance. Randomized control trial. HOME DES IVUS.

JAKABČIN, Jozef; Radim ŠPAČEK; Marian BYSTROŇ; Martin KVAŠŇÁK; Jiří JAGER et al.

Základní údaje

Originální název

Long-term health outcome and mortality evaluation after invasive coronary treatment using drug eluting stents with or without the IVUS guidance. Randomized control trial. HOME DES IVUS.

Autoři

JAKABČIN, Jozef; Radim ŠPAČEK; Marian BYSTROŇ; Martin KVAŠŇÁK; Jiří JAGER; Josef VESELKA; Petr KALA a Pavel CERVINKA

Vydání

Catheterization and Cardiovascular Intervention, 2010, 1522-1946

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.398

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/10:00051312

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1002/ccd.22244

UT WoS

000276588600021

Klíčová slova anglicky

BARE-METAL STENTS; INTRAVASCULAR ULTRASOUND ANALYSIS; ARTERY-DISEASE; DOUBLE-BLIND; FOLLOW-UP; IMPLANTATION; THROMBOSIS; RISK; 6-MONTH; LESIONS

Příznaky

Mezinárodní význam

Změněno: 12. 12. 2011 15:39, Mgr. Michal Petr

Anotace

V originále

Objective: To assess the role of the intravascular ultrasound (IVUS) during implantation of Drug-eluting stents (DES) on long-term outcome in patients with complex coronary artery disease and high clinical risk profile with special attention to the development of late stent thrombosis (LST). Methods: Two hunderd and ten patients were randomly assigned to receive DES either with (N = 105) or without (N = 105) the IVUS guidance. Dual antiplatelet treatment was administered for 6 months in all patients. At 18-month follow-up, the rates of Major adverse cardiac events (MACEs) (death, myocardial infarction, and reintervention) were assessed in both groups with special attention to possible LST. Stent thrombosis was classified according to Academic Research Consortium (ARC). Results: At the 18-month follow-up, there was no significant difference between both groups regarding MACE (11% vs. 12%; P = NS). Stent thrombosis has occurred in four patients (3.8%) in the group with and in 6 patients (5.7%; P = NS) in the group without the IVUS guidance. Conclusions: In our randomized trial we failed to demonstrate the superiority of the IVUS guidance during DES implantation over standard high-pressure postdilatation. However we confirmed worrisome results concerning DES thrombosis after discontinuation of dual antiplatelet-treatment with documented stent thrombosis related events in almost 5% of patients with 50% of mortality in this high-risk clinical scenario.

Citovat

JAKABČIN, Jozef; Radim ŠPAČEK; Marian BYSTROŇ; Martin KVAŠŇÁK; Jiří JAGER; Josef VESELKA; Petr KALA a Pavel CERVINKA. Long-term health outcome and mortality evaluation after invasive coronary treatment using drug eluting stents with or without the IVUS guidance. Randomized control trial. HOME DES IVUS. Catheterization and Cardiovascular Intervention. 2010, roč. 75, č. 4, s. 578-583. ISSN 1522-1946. Dostupné z: https://doi.org/10.1002/ccd.22244.

@article{875395,
   author = {Jakabčin, Jozef and Špaček, Radim and Bystroň, Marian and Kvašňák, Martin and Jager, Jiří and Veselka, Josef and Kala, Petr and Cervinka, Pavel},
   article_number = {4},
   doi = {https://doi.org/10.1002/ccd.22244},
   keywords = {BARE-METAL STENTS; INTRAVASCULAR ULTRASOUND ANALYSIS; ARTERY-DISEASE; DOUBLE-BLIND; FOLLOW-UP; IMPLANTATION; THROMBOSIS; RISK; 6-MONTH; LESIONS},
   language = {eng},
   issn = {1522-1946},
   journal = {Catheterization and Cardiovascular Intervention},
   title = {Long-term health outcome and mortality evaluation after invasive coronary treatment using drug eluting stents with or without the IVUS guidance. Randomized control trial. HOME DES IVUS.},
   volume = {75},
   year = {2010}
}

TY  - JOUR
ID  - 875395
AU  - Jakabčin, Jozef - Špaček, Radim - Bystroň, Marian - Kvašňák, Martin - Jager, Jiří - Veselka, Josef - Kala, Petr - Cervinka, Pavel
PY  - 2010
TI  - Long-term health outcome and mortality evaluation after invasive coronary treatment using drug eluting stents with or without the IVUS guidance. Randomized control trial. HOME DES IVUS.
JF  - Catheterization and Cardiovascular Intervention
VL  - 75
IS  - 4
SP  - 578-583
EP  - 578-583
SN  - 15221946
KW  - BARE-METAL STENTS
KW  - INTRAVASCULAR ULTRASOUND ANALYSIS
KW  - ARTERY-DISEASE
KW  - DOUBLE-BLIND
KW  - FOLLOW-UP
KW  - IMPLANTATION
KW  - THROMBOSIS
KW  - RISK
KW  - 6-MONTH
KW  - LESIONS
N2  - Objective: To assess the role of the intravascular ultrasound (IVUS) during implantation of Drug-eluting stents (DES) on long-term outcome in patients with complex coronary artery disease and high clinical risk profile with special attention to the development of late stent thrombosis (LST). Methods: Two hunderd and ten patients were randomly assigned to receive DES either with (N = 105) or without (N = 105) the IVUS guidance. Dual antiplatelet treatment was administered for 6 months in all patients. At 18-month follow-up, the rates of Major adverse cardiac events (MACEs) (death, myocardial infarction, and reintervention) were assessed in both groups with special attention to possible LST. Stent thrombosis was classified according to Academic Research Consortium (ARC). Results: At the 18-month follow-up, there was no significant difference between both groups regarding MACE (11% vs. 12%; P = NS). Stent thrombosis has occurred in four patients (3.8%) in the group with and in 6 patients (5.7%; P = NS) in the group without the IVUS guidance. Conclusions: In our randomized trial we failed to demonstrate the superiority of the IVUS guidance during DES implantation over standard high-pressure postdilatation. However we confirmed worrisome results concerning DES thrombosis after discontinuation of dual antiplatelet-treatment with documented stent thrombosis related events in almost 5% of patients with 50% of mortality in this high-risk clinical scenario.
ER  -

JAKABČIN, Jozef; Radim ŠPAČEK; Marian BYSTROŇ; Martin KVAŠŇÁK; Jiří JAGER; Josef VESELKA; Petr KALA a Pavel CERVINKA. Long-term health outcome and mortality evaluation after invasive coronary treatment using drug eluting stents with or without the IVUS guidance. Randomized control trial. HOME DES IVUS. \textit{Catheterization and Cardiovascular Intervention}. 2010, roč.~75, č.~4, s.~578-583. ISSN~1522-1946. Dostupné z: https://doi.org/10.1002/ccd.22244.

Přehled o publikaci