Optimal pretreatment timing for high load dosing (600 mg) of
clopidogrel before planned percutaneous coronary intervention
for maximal antiplatelet effectiveness.

J 2009

Optimal pretreatment timing for high load dosing (600 mg) of clopidogrel before planned percutaneous coronary intervention for maximal antiplatelet effectiveness.

MOTOVSKÁ, Zuzana; Petr WIDIMSKÝ; Robert PETR; Dana BILKOVA; Iuri MARINOV et al.

Základní údaje

Originální název

Optimal pretreatment timing for high load dosing (600 mg) of clopidogrel before planned percutaneous coronary intervention for maximal antiplatelet effectiveness.

Autoři

MOTOVSKÁ, Zuzana; Petr WIDIMSKÝ; Robert PETR; Dana BILKOVA; Iuri MARINOV; Stanislav ŠIMEK a Petr KALA

Vydání

International Journal of Cardiology, 2009, 0167-5273

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.469

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/09:00051313

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1016/j.ijcard.2009.01.017

UT WoS

000282678300033

Klíčová slova anglicky

Clopidogrel; Pretreatment; Elective coronary angiography

Příznaky

Mezinárodní význam

Změněno: 12. 12. 2011 15:48, Mgr. Michal Petr

Anotace

V originále

The optimal timing for 600 mg clopidogrel pre-treatment before planned PCI in patients with stable coronary artery disease has never been tested in a randomized trial. Methods The time course of platelet inhibition was investigated in 105 patients pre-treated with clopidogrel 6 h before the planned procedure. Flow cytometric analysis of the vasodilator stimulated phosphoprotein (VASP) phosphorylation state was done and a Platelet Reactivity Index (PRI) was calculated prior to treatment (baseline) and at 12, 28, 36, 60, 84 and 108 h after the clopidogrel loading dose administration. Conclusion The time curve of clopidogrel efficacy was dependent on baseline platelet reactivity. Among stable CAD patients, pre-treatment with 600 mg of clopidogrel resulted in maximal antiplatelet efficacy 1 day after drug administration.

Citovat

MOTOVSKÁ, Zuzana; Petr WIDIMSKÝ; Robert PETR; Dana BILKOVA; Iuri MARINOV; Stanislav ŠIMEK a Petr KALA. Optimal pretreatment timing for high load dosing (600 mg) of clopidogrel before planned percutaneous coronary intervention for maximal antiplatelet effectiveness. International Journal of Cardiology. 2009, roč. 144, č. 2, s. 255-257. ISSN 0167-5273. Dostupné z: https://doi.org/10.1016/j.ijcard.2009.01.017.

@article{875398,
   author = {Motovská, Zuzana and Widimský, Petr and Petr, Robert and Bilkova, Dana and Marinov, Iuri and Šimek, Stanislav and Kala, Petr},
   article_number = {2},
   doi = {https://doi.org/10.1016/j.ijcard.2009.01.017},
   keywords = {Clopidogrel; Pretreatment; Elective coronary angiography},
   language = {eng},
   issn = {0167-5273},
   journal = {International Journal of Cardiology},
   title = {Optimal pretreatment timing for high load dosing (600 mg) of clopidogrel before planned percutaneous coronary intervention for maximal antiplatelet effectiveness.},
   volume = {144},
   year = {2009}
}

TY  - JOUR
ID  - 875398
AU  - Motovská, Zuzana - Widimský, Petr - Petr, Robert - Bilkova, Dana - Marinov, Iuri - Šimek, Stanislav - Kala, Petr
PY  - 2009
TI  - Optimal pretreatment timing for high load dosing (600 mg) of clopidogrel before planned percutaneous coronary intervention for maximal antiplatelet effectiveness.
JF  - International Journal of Cardiology
VL  - 144
IS  - 2
SP  - 255-257
EP  - 255-257
SN  - 01675273
KW  - Clopidogrel
KW  - Pretreatment
KW  - Elective coronary angiography
N2  - The optimal timing for 600 mg clopidogrel pre-treatment before planned PCI in patients with stable coronary artery disease has never been tested in a randomized trial. Methods The time course of platelet inhibition was investigated in 105 patients pre-treated with clopidogrel 6 h before the planned procedure. Flow cytometric analysis of the vasodilator stimulated phosphoprotein (VASP) phosphorylation state was done and a Platelet Reactivity Index (PRI) was calculated prior to treatment (baseline) and at 12, 28, 36, 60, 84 and 108 h after the clopidogrel loading dose administration. Conclusion The time curve of clopidogrel efficacy was dependent on baseline platelet reactivity. Among stable CAD patients, pre-treatment with 600 mg of clopidogrel resulted in maximal antiplatelet efficacy 1 day after drug administration.
ER  -

MOTOVSKÁ, Zuzana; Petr WIDIMSKÝ; Robert PETR; Dana BILKOVA; Iuri MARINOV; Stanislav ŠIMEK a Petr KALA. Optimal pretreatment timing for high load dosing (600 mg) of clopidogrel before planned percutaneous coronary intervention for maximal antiplatelet effectiveness. \textit{International Journal of Cardiology}. 2009, roč.~144, č.~2, s.~255-257. ISSN~0167-5273. Dostupné z: https://doi.org/10.1016/j.ijcard.2009.01.017.

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