NĚMEC, Petr, Monika PAVKOVA-GOLDBERGOVA, Jindra GATTEROVÁ, Anna VAŠKŮ a Miroslava SOUČEK. Association of polymorfism in interleukin-10 gene promoter with antibody production in patients with rhematoid arthritis. Ann N Y Acad Sci. New York, USA: New York Academy of Sciences, 2009, roč. 1173, č. 25, s. 501-508, 7 s. ISSN 0077-8923. |
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@article{875827, author = {Němec, Petr and PavkovaandGoldbergova, Monika and Gatterová, Jindra and Vašků, Anna and Souček, Miroslava}, article_location = {New York, USA}, article_number = {25}, keywords = {autoantibody; gene; interleukin-10; polymorphism; rheumatoid arthritis; severity}, language = {eng}, issn = {0077-8923}, journal = {Ann N Y Acad Sci}, title = {Association of polymorfism in interleukin-10 gene promoter with antibody production in patients with rhematoid arthritis}, volume = {1173}, year = {2009} }
TY - JOUR ID - 875827 AU - Němec, Petr - Pavkova-Goldbergova, Monika - Gatterová, Jindra - Vašků, Anna - Souček, Miroslava PY - 2009 TI - Association of polymorfism in interleukin-10 gene promoter with antibody production in patients with rhematoid arthritis JF - Ann N Y Acad Sci VL - 1173 IS - 25 SP - 501-508 EP - 501-508 PB - New York Academy of Sciences SN - 00778923 KW - autoantibody KW - gene KW - interleukin-10 KW - polymorphism KW - rheumatoid arthritis KW - severity N2 - Interleukin-10 (IL-10) is a major anti-inflammatory cytokine that plays a crucial role in the regulation of the immune system. Allelic polymorphisms in the IL-10 gene promoter may contribute to the regulation of autoantibody production. To examine the association between both individuals IL-10 single nucleotide polymorphisms and the production of autoantibodies and the radiographic progression of rheumatoid arthritis (RA), a total of 144 RA patients were recruited into the study. We found significant differences in genotype distribution of the -1082G/A polymorphism between IgG, IgA, and IgM rheumatoid factor(RF)-positive/negative RA patients. We also found significant differences in allelic frequencies of the -3575T/A, -819C/T, and -592A/C polymorphisms between anticyclic citrullinated peptide (anti-CCP)-positive/negative RA patients. The haplotype TGAATA was found to be less frequent within anti-CCP-positive RA patients. Results obtained in this study provide evidence of an association between polymorphisms in IL-10 gene promoter and the production of autoantibodies in RA patients. ER -
NĚMEC, Petr, Monika PAVKOVA-GOLDBERGOVA, Jindra GATTEROVÁ, Anna VAŠKŮ a Miroslava SOUČEK. Association of polymorfism in interleukin-10 gene promoter with antibody production in patients with rhematoid arthritis. \textit{Ann N Y Acad Sci}. New York, USA: New York Academy of Sciences, 2009, roč.~1173, č.~25, s.~501-508, 7 s. ISSN~0077-8923.
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