Association of polymorfism in interleukin-10 gene promoter with
antibody production in patients with rhematoid arthritis

J 2009

Association of polymorfism in interleukin-10 gene promoter with antibody production in patients with rhematoid arthritis

NĚMEC, Petr, Monika PAVKOVA-GOLDBERGOVA, Jindra GATTEROVÁ, Anna VAŠKŮ, Miroslava SOUČEK et. al.

Základní údaje

Originální název

Association of polymorfism in interleukin-10 gene promoter with antibody production in patients with rhematoid arthritis

Autoři

NĚMEC, Petr (203 Česká republika, garant), Monika PAVKOVA-GOLDBERGOVA (203 Česká republika), Jindra GATTEROVÁ (203 Česká republika), Anna VAŠKŮ (203 Česká republika) a Miroslava SOUČEK (203 Česká republika)

Vydání

Ann N Y Acad Sci, New York, USA, New York Academy of Sciences, 2009, 0077-8923

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.670

Kód RIV

RIV/00216224:14110/09:00039388

Organizační jednotka

Lékařská fakulta

UT WoS

000270762800070

Klíčová slova anglicky

autoantibody; gene; interleukin-10; polymorphism; rheumatoid arthritis; severity

Změněno: 22. 3. 2010 09:02, prof. MUDr. Anna Vašků, CSc.

Anotace

V originále

Interleukin-10 (IL-10) is a major anti-inflammatory cytokine that plays a crucial role in the regulation of the immune system. Allelic polymorphisms in the IL-10 gene promoter may contribute to the regulation of autoantibody production. To examine the association between both individuals IL-10 single nucleotide polymorphisms and the production of autoantibodies and the radiographic progression of rheumatoid arthritis (RA), a total of 144 RA patients were recruited into the study. We found significant differences in genotype distribution of the -1082G/A polymorphism between IgG, IgA, and IgM rheumatoid factor(RF)-positive/negative RA patients. We also found significant differences in allelic frequencies of the -3575T/A, -819C/T, and -592A/C polymorphisms between anticyclic citrullinated peptide (anti-CCP)-positive/negative RA patients. The haplotype TGAATA was found to be less frequent within anti-CCP-positive RA patients. Results obtained in this study provide evidence of an association between polymorphisms in IL-10 gene promoter and the production of autoantibodies in RA patients.

Citovat

NĚMEC, Petr, Monika PAVKOVA-GOLDBERGOVA, Jindra GATTEROVÁ, Anna VAŠKŮ a Miroslava SOUČEK. Association of polymorfism in interleukin-10 gene promoter with antibody production in patients with rhematoid arthritis. Ann N Y Acad Sci. New York, USA: New York Academy of Sciences, 2009, roč. 1173, č. 25, s. 501-508, 7 s. ISSN 0077-8923.

@article{875827,
   author = {Němec, Petr and PavkovaandGoldbergova, Monika and Gatterová, Jindra and Vašků, Anna and Souček, Miroslava},
   article_location = {New York, USA},
   article_number = {25},
   keywords = {autoantibody; gene; interleukin-10; polymorphism; rheumatoid arthritis; severity},
   language = {eng},
   issn = {0077-8923},
   journal = {Ann N Y Acad Sci},
   title = {Association of polymorfism in interleukin-10 gene promoter with antibody production in patients with rhematoid arthritis},
   volume = {1173},
   year = {2009}
}

TY  - JOUR
ID  - 875827
AU  - Němec, Petr - Pavkova-Goldbergova, Monika - Gatterová, Jindra - Vašků, Anna - Souček, Miroslava
PY  - 2009
TI  - Association of polymorfism in interleukin-10 gene promoter with antibody production in patients with rhematoid arthritis
JF  - Ann N Y Acad Sci
VL  - 1173
IS  - 25
SP  - 501-508
EP  - 501-508
PB  - New York Academy of Sciences
SN  - 00778923
KW  - autoantibody
KW  - gene
KW  - interleukin-10
KW  - polymorphism
KW  - rheumatoid arthritis
KW  - severity
N2  - Interleukin-10 (IL-10) is a major anti-inflammatory cytokine that plays a crucial role in the regulation of the immune system. Allelic polymorphisms in the IL-10 gene promoter may contribute to the regulation of autoantibody production. To examine the association between both individuals IL-10 single nucleotide polymorphisms and the production of autoantibodies and the radiographic progression of rheumatoid arthritis (RA), a total of 144 RA patients were recruited into the study. We found significant differences in genotype distribution of the -1082G/A polymorphism between IgG, IgA, and IgM rheumatoid factor(RF)-positive/negative RA patients. We also found significant differences in allelic frequencies of the -3575T/A, -819C/T, and -592A/C polymorphisms between anticyclic citrullinated peptide (anti-CCP)-positive/negative RA patients. The haplotype TGAATA was found to be less frequent within anti-CCP-positive RA patients. Results obtained in this study provide evidence of an association between polymorphisms in IL-10 gene promoter and the production of autoantibodies in RA patients.
ER  -

NĚMEC, Petr, Monika PAVKOVA-GOLDBERGOVA, Jindra GATTEROVÁ, Anna VAŠKŮ a Miroslava SOUČEK. Association of polymorfism in interleukin-10 gene promoter with antibody production in patients with rhematoid arthritis. \textit{Ann N Y Acad Sci}. New York, USA: New York Academy of Sciences, 2009, roč.~1173, č.~25, s.~501-508, 7 s. ISSN~0077-8923.

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