Association of the 5A/6A promoter polymorphism of the MMP-3
gene with the radiographic progression of rheumatoid arthritis

J 2007

Association of the 5A/6A promoter polymorphism of the MMP-3 gene with the radiographic progression of rheumatoid arthritis

NĚMEC, Petr; Monika PAVKOVA-GOLDBERGOVA; Jindra GATTEROVÁ; Anna VAŠKŮ; Miroslav SOUČEK et al.

Základní údaje

Originální název

Association of the 5A/6A promoter polymorphism of the MMP-3 gene with the radiographic progression of rheumatoid arthritis

Autoři

NĚMEC, Petr; Monika PAVKOVA-GOLDBERGOVA; Jindra GATTEROVÁ; Anna VAŠKŮ a Miroslav SOUČEK

Vydání

Ann N Y Acad Sci. New York, USA, N Y Acad Sci, 2007, 0077-8923

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.731

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/07:00039491

Organizační jednotka

Lékařská fakulta

UT WoS

000250428100020

Klíčová slova anglicky

gene; matrix metalloproteinase; polymorphism; progression; rheumatoid arthritis

Změněno: 21. 3. 2010 16:19, doc. MUDr. Helena Němcová, CSc.

Anotace

V originále

Matrix metalloproteinases (MMPs) as a family of zinc-dependent endopeptidases have been involved in remodeling the extracellular matrix (ECM) in rheumatoid arthritis (RA). In RA patients synovial fluid and serum include enhanced levels of MMP-3. The 5A/6A polymorphism in the MMP-3 gene promoter can contribute to the severity of RA on account of a higher promoter activity of the 5A allele in vitro. The aim of the study was to associate the 5A/6A polymorphism of the MMP-3 gene with radiographic progression of RA. A total of 128 RA patients according to the ACR criteria were available for the study. Radiographs of both hands, obtained from all RA patients, were scored using the modified Sharp/van der Heijde method and the Steinbrocker method. The total Sharp score (TSS) and the annual radiographic progression rate (TSS/year) were calculated. Significant association with the 5A/6A polymorphism was found between patients with TSS/year 1.00 in allelic frequencies (Pa = 0.046) and also in genotype distribution (Pg = 0.04). Compared to other genotypes the prevalence of 5A/5A genotype was lower within patients with TSS/year 1.00 in allelic frequencies (Pa = 0.046) and also in genotype distribution (Pg = 0.04). Compared to other genotypes the prevalence of 5A/5A genotype was lower within patients with TSS/year 1.00 in allelic frequencies (Pa = 0.046) and also in genotype distribution (Pg = 0.04). Compared to other genotypes the prevalence of 5A/5A genotype was lower within patients with TSS/year 1.00 in allelic frequencies (Pa = 0.046) and also in genotype distribution (Pg = 0.04). Compared to other genotypes the prevalence of 5A/5A genotype was lower within patients with TSS/year 1.00 in allelic frequencies (Pa = 0.046) and also in genotype distribution (Pg = 0.04). Compared to other genotypes the prevalence of 5A/5A genotype was lower within patients with TSS/year

Citovat

NĚMEC, Petr; Monika PAVKOVA-GOLDBERGOVA; Jindra GATTEROVÁ; Anna VAŠKŮ a Miroslav SOUČEK. Association of the 5A/6A promoter polymorphism of the MMP-3 gene with the radiographic progression of rheumatoid arthritis. Ann N Y Acad Sci. New York, USA: N Y Acad Sci, 2007, roč. 1110, č. 1, s. 166-176. ISSN 0077-8923.

@article{876456,
   author = {Němec, Petr and PavkovaandGoldbergova, Monika and Gatterová, Jindra and Vašků, Anna and Souček, Miroslav},
   article_location = {New York, USA},
   article_number = {1},
   keywords = {gene; matrix metalloproteinase; polymorphism; progression; rheumatoid arthritis},
   language = {eng},
   issn = {0077-8923},
   journal = {Ann N Y Acad Sci.},
   title = {Association of the 5A/6A promoter polymorphism of the MMP-3 gene with the radiographic progression of rheumatoid arthritis},
   volume = {1110},
   year = {2007}
}

TY  - JOUR
ID  - 876456
AU  - Němec, Petr - Pavkova-Goldbergova, Monika - Gatterová, Jindra - Vašků, Anna - Souček, Miroslav
PY  - 2007
TI  - Association of the 5A/6A promoter polymorphism of the MMP-3 gene with the radiographic progression of rheumatoid arthritis
JF  - Ann N Y Acad Sci.
VL  - 1110
IS  - 1
SP  - 166-176
EP  - 166-176
PB  - N Y Acad Sci
SN  - 00778923
KW  - gene
KW  - matrix metalloproteinase
KW  - polymorphism
KW  - progression
KW  - rheumatoid arthritis
N2  - Matrix metalloproteinases (MMPs) as a family of zinc-dependent endopeptidases have been involved in remodeling the extracellular matrix (ECM) in rheumatoid arthritis (RA). In RA patients synovial fluid and serum include enhanced levels of MMP-3. The 5A/6A polymorphism in the MMP-3 gene promoter can contribute to the severity of RA on account of a higher promoter activity of the 5A allele in vitro. The aim of the study was to associate the 5A/6A polymorphism of the MMP-3 gene with radiographic progression of RA. A total of 128 RA patients according to the ACR criteria were available for the study. Radiographs of both hands, obtained from all RA patients, were scored using the modified Sharp/van der Heijde method and the Steinbrocker method. The total Sharp score (TSS) and the annual radiographic progression rate (TSS/year) were calculated. Significant association with the 5A/6A polymorphism was found between patients with TSS/year 1.00 in allelic frequencies (Pa = 0.046) and also in genotype distribution (Pg = 0.04). Compared to other genotypes the prevalence of 5A/5A genotype was lower within patients with TSS/year 1.00 in allelic frequencies (Pa = 0.046) and also in genotype distribution (Pg = 0.04). Compared to other genotypes the prevalence of 5A/5A genotype was lower within patients with TSS/year 1.00 in allelic frequencies (Pa = 0.046) and also in genotype distribution (Pg = 0.04). Compared to other genotypes the prevalence of 5A/5A genotype was lower within patients with TSS/year 1.00 in allelic frequencies (Pa = 0.046) and also in genotype distribution (Pg = 0.04). Compared to other genotypes the prevalence of 5A/5A genotype was lower within patients with TSS/year 1.00 in allelic frequencies (Pa = 0.046) and also in genotype distribution (Pg = 0.04). Compared to other genotypes the prevalence of 5A/5A genotype was lower within patients with TSS/year
ER  -

NĚMEC, Petr; Monika PAVKOVA-GOLDBERGOVA; Jindra GATTEROVÁ; Anna VAŠKŮ a Miroslav SOUČEK. Association of the 5A/6A promoter polymorphism of the MMP-3 gene with the radiographic progression of rheumatoid arthritis. \textit{Ann N Y Acad Sci.}. New York, USA: N Y Acad Sci, 2007, roč.~1110, č.~1, s.~166-176. ISSN~0077-8923.

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