Polymorphism in the tumor necrosis factor-alpha gene promoter
is associated with severity of rheumatoid arthritis in the
Czech population.

J 2008

Polymorphism in the tumor necrosis factor-alpha gene promoter is associated with severity of rheumatoid arthritis in the Czech population.

NĚMEC, Petr; Monika PÁVKOVÁ GOLDBERGOVÁ; M. STOURACOVA; Anna VAŠKŮ; Miroslav SOUČEK et al.

Základní údaje

Originální název

Polymorphism in the tumor necrosis factor-alpha gene promoter is associated with severity of rheumatoid arthritis in the Czech population.

Autoři

NĚMEC, Petr; Monika PÁVKOVÁ GOLDBERGOVÁ; M. STOURACOVA; Anna VAŠKŮ a Miroslav SOUČEK

Vydání

Clin Rheumatol, London, Springer, 2008, 0770-3198

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.559

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/08:00039497

Organizační jednotka

Lékařská fakulta

UT WoS

000251151500010

Klíčová slova anglicky

gene ; polymorphism; progression; rheumatoid arthritis

Změněno: 21. 3. 2010 18:34, doc. MUDr. Helena Němcová, CSc.

Anotace

V originále

Rheumatoid arthritis (RA) is a model of multigenic inflammatory disorder in which tumor necrosis factor-alpha (TNF-alpha) plays an important role. Genetic factors may be implicated in the susceptibility to disease initiation as well as in severity of disease course. Elevated levels of TNF-alpha in the plasma and synovial fluid from RA patients may be associated with polymorphisms in the promoter region of the TNF-alpha gene. The aim of this study was to elucidate putative association between the -308 G/A polymorphism in the promoter region of the TNF-alpha gene and susceptibility to onset and severity of RA. A total of 130 RA patients and a control group of 150 healthy subjects with similar age and sex distribution were available for the study. All patients fulfilled the American College of Rheumatology revised criteria for RA. RA patients had a disease duration of at least 2 years. Radiographs of both hands of all RA patients were scored with the Steinbrocker method. There were 15 patients of stage I (nonerosive form) of RA and 114 patients of stages II-IV (erosive form). To assess the RA patient's functional ability, the Health Assessment Questionnaire (HAQ) was used. The -308 G/A promoter polymorphism of the TNF-alpha gene was detected by polymerase chain reaction and restriction fragment length polymorphism analysis. No differences in genotype distribution and allelic frequences of -308 G/A TNF-alpha promoter polymorphism have been found between RA patients and the control group. Significant differences have been observed within the RA group divided according to the radiographic progression of disease based on the Steinbrocker radiographic score and functional ability (HAQ). These results suggest an association of the -308 G/A polymorphism of the TNF-alpha gene with the severity of RA.

Citovat

NĚMEC, Petr; Monika PÁVKOVÁ GOLDBERGOVÁ; M. STOURACOVA; Anna VAŠKŮ a Miroslav SOUČEK. Polymorphism in the tumor necrosis factor-alpha gene promoter is associated with severity of rheumatoid arthritis in the Czech population. Clin Rheumatol. London: Springer, 2008, roč. 27, č. 1, s. 59-65. ISSN 0770-3198.

@article{876468,
   author = {Němec, Petr and Pávková Goldbergová, Monika and Stouracova, M. and Vašků, Anna and Souček, Miroslav},
   article_location = {London},
   article_number = {1},
   keywords = {gene ; polymorphism; progression; rheumatoid arthritis},
   language = {eng},
   issn = {0770-3198},
   journal = {Clin Rheumatol},
   title = {Polymorphism in the tumor necrosis factor-alpha gene promoter is associated with severity of rheumatoid arthritis in the Czech population.},
   volume = {27},
   year = {2008}
}

TY  - JOUR
ID  - 876468
AU  - Němec, Petr - Pávková Goldbergová, Monika - Stouracova, M. - Vašků, Anna - Souček, Miroslav
PY  - 2008
TI  - Polymorphism in the tumor necrosis factor-alpha gene promoter is associated with severity of rheumatoid arthritis in the Czech population.
JF  - Clin Rheumatol
VL  - 27
IS  - 1
SP  - 59-65
EP  - 59-65
PB  - Springer
SN  - 07703198
KW  - gene
KW  - polymorphism
KW  - progression
KW  - rheumatoid arthritis
N2  - Rheumatoid arthritis (RA) is a model of multigenic inflammatory disorder in which tumor necrosis factor-alpha (TNF-alpha) plays an important role. Genetic factors may be implicated in the susceptibility to disease initiation as well as in severity of disease course. Elevated levels of TNF-alpha in the plasma and synovial fluid from RA patients may be associated with polymorphisms in the promoter region of the TNF-alpha gene. The aim of this study was to elucidate putative association between the -308 G/A polymorphism in the promoter region of the TNF-alpha gene and susceptibility to onset and severity of RA. A total of 130 RA patients and a control group of 150 healthy subjects with similar age and sex distribution were available for the study. All patients fulfilled the American College of Rheumatology revised criteria for RA. RA patients had a disease duration of at least 2 years. Radiographs of both hands of all RA patients were scored with the Steinbrocker method. There were 15 patients of stage I (nonerosive form) of RA and 114 patients of stages II-IV (erosive form). To assess the RA patient's functional ability, the Health Assessment Questionnaire (HAQ) was used. The -308 G/A promoter polymorphism of the TNF-alpha gene was detected by polymerase chain reaction and restriction fragment length polymorphism analysis. No differences in genotype distribution and allelic frequences of -308 G/A TNF-alpha promoter polymorphism have been found between RA patients and the control group. Significant differences have been observed within the RA group divided according to the radiographic progression of disease based on the Steinbrocker radiographic score and functional ability (HAQ). These results suggest an association of the -308 G/A polymorphism of the TNF-alpha gene with the severity of RA.
ER  -

NĚMEC, Petr; Monika PÁVKOVÁ GOLDBERGOVÁ; M. STOURACOVA; Anna VAŠKŮ a Miroslav SOUČEK. Polymorphism in the tumor necrosis factor-alpha gene promoter is associated with severity of rheumatoid arthritis in the Czech population. \textit{Clin Rheumatol}. London: Springer, 2008, roč.~27, č.~1, s.~59-65. ISSN~0770-3198.

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