KUČERA, Jan, Lukáš KUBALA, Hana KOTASOVÁ, Kateřina ŠTEFKOVÁ, Jiřina PROCHÁZKOVÁ a Jiří PACHERNÍK. Modulation of gp130 Signalling by Inhibitors of Reactive Oxygen Species Formation in Mouse Embryonic Stem Cells. FREE RADICAL BIOLOGY AND MEDICINE. New York, NY, USA: ELSEVIER SCIENCE INC, 2009, roč. 47, zima, s. 18-19. ISSN 0891-5849. |
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@article{879419, author = {Kučera, Jan and Kubala, Lukáš and Kotasová, Hana and Štefková, Kateřina and Procházková, Jiřina and Pacherník, Jiří}, article_location = {New York, NY, USA}, article_number = {zima}, keywords = {stem cells; gp130; reactive oxgen species; ROS; hypoxia; redox modulators;}, language = {eng}, issn = {0891-5849}, journal = {FREE RADICAL BIOLOGY AND MEDICINE}, title = {Modulation of gp130 Signalling by Inhibitors of Reactive Oxygen Species Formation in Mouse Embryonic Stem Cells}, volume = {47}, year = {2009} }
TY - JOUR ID - 879419 AU - Kučera, Jan - Kubala, Lukáš - Kotasová, Hana - Štefková, Kateřina - Procházková, Jiřina - Pacherník, Jiří PY - 2009 TI - Modulation of gp130 Signalling by Inhibitors of Reactive Oxygen Species Formation in Mouse Embryonic Stem Cells JF - FREE RADICAL BIOLOGY AND MEDICINE VL - 47 IS - zima SP - 18 EP - 18 PB - ELSEVIER SCIENCE INC SN - 08915849 KW - stem cells KW - gp130 KW - reactive oxgen species KW - ROS KW - hypoxia KW - redox modulators; N2 - The gp130 system is a set of ligands and receptors that dominantly involves the activation of the JAK/STAT, Erk, and PI3K/Akt pathways. gp130 is suggested to play a key role in response of stem cells to both the mediators that maintain stem cell undifferentiated phenotype and the mediators inducing differentiation. Under physiological conditions in their niche, stem cells are kept in hypoxic microenvironment. Leaving their niche they are exposed to normal levels of oxygen. Thus reactive oxygen species (ROS) formation in stem cells due to hypoxic conditions could be considered as important regulator of stem cell fate. Here we analyzed effects of inhibitors of NADPH oxidases apocynin or diphenyleneiodonium (DPI), and a glutathione precursor N-acetyl-cysteine (NAC) on activity of gp130 signaling pathways and maintenance of mouse ES cells. The obtained results are compared with effects of ES cells culture in hypoxia condition. ER -
KUČERA, Jan, Lukáš KUBALA, Hana KOTASOVÁ, Kateřina ŠTEFKOVÁ, Jiřina PROCHÁZKOVÁ a Jiří PACHERNÍK. Modulation of gp130 Signalling by Inhibitors of Reactive Oxygen Species Formation in Mouse Embryonic Stem Cells. \textit{FREE RADICAL BIOLOGY AND MEDICINE}. New York, NY, USA: ELSEVIER SCIENCE INC, 2009, roč.~47, zima, s.~18-19. ISSN~0891-5849.
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