Modulation of cell proliferation and differentiation of human
lung carcinoma cells by the interferon-alpha

J 2009

Modulation of cell proliferation and differentiation of human lung carcinoma cells by the interferon-alpha

KREJČOVÁ, Daniela; Jiřina PROCHÁZKOVÁ; Jiří PACHERNÍK a Lukáš KUBALA

Základní údaje

Originální název

Modulation of cell proliferation and differentiation of human lung carcinoma cells by the interferon-alpha

Autoři

KREJČOVÁ, Daniela (203 Česká republika); Jiřina PROCHÁZKOVÁ (203 Česká republika); Jiří PACHERNÍK (203 Česká republika) a Lukáš KUBALA (203 Česká republika, garant)

Vydání

GENERAL PHYSIOLOGY AND BIOPHYSICS, 2009, 0231-5882

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Slovensko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.741

Kód RIV

RIV/00216224:14110/09:00028863

Organizační jednotka

Lékařská fakulta

UT WoS

000272335700010

Klíčová slova anglicky

Non-small cell lung cancer; ABC transporter proteins; Cell cycle; Interferons

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 7. 2010 10:10, Mgr. Jiřina Medalová, Ph.D.

Anotace

V originále

Interferon alpha (IFN-alpha), an important physiological immunomodulator, possesses direct cytotoxic and cytostatic effects on tumour cells, antiangiogenic effects, and activates anti-tumour immunity. Herein the human lung carcinoma cell line A549, a model of NSCLC in vitro, was used to pursue the effect of IFN-alpha on A549 cell proliferation and differentiation together with the effect on protein expression and activity of three ATP-transporters mediating multi-drug resistance (MDR). IFN-alpha significantly inhibited the proliferation of A549 cells which was not connected with arrest in a particular cell cycle phase. IFN-alpha-mediated differentiation of A549 was observed based on an increase in alkaline phosphatase activity. Simultaneously, IFN-alpha increased the expression and activity of ATP-transporters mediating MDR. The IFN-alpha down-regulation of NSCLC cell proliferation was accompanied by a potential of cells to exclude potential therapeutic substances such as chemotherapeutic agents.

Citovat

KREJČOVÁ, Daniela; Jiřina PROCHÁZKOVÁ; Jiří PACHERNÍK a Lukáš KUBALA. Modulation of cell proliferation and differentiation of human lung carcinoma cells by the interferon-alpha. GENERAL PHYSIOLOGY AND BIOPHYSICS. 2009, roč. 28, č. 3, 8 s. ISSN 0231-5882.

@article{879427,
   author = {Krejčová, Daniela and Procházková, Jiřina and Pacherník, Jiří and Kubala, Lukáš},
   article_number = {3},
   keywords = {Non-small cell lung cancer; ABC transporter proteins; Cell cycle; Interferons},
   language = {eng},
   issn = {0231-5882},
   journal = {GENERAL PHYSIOLOGY AND BIOPHYSICS},
   title = {Modulation of cell proliferation and differentiation of human lung carcinoma cells by the interferon-alpha},
   volume = {28},
   year = {2009}
}

TY  - JOUR
ID  - 879427
AU  - Krejčová, Daniela - Procházková, Jiřina - Pacherník, Jiří - Kubala, Lukáš
PY  - 2009
TI  - Modulation of cell proliferation and differentiation of human lung carcinoma cells by the interferon-alpha
JF  - GENERAL PHYSIOLOGY AND BIOPHYSICS
VL  - 28
IS  - 3
SN  - 02315882
KW  - Non-small cell lung cancer
KW  - ABC transporter proteins
KW  - Cell cycle
KW  - Interferons
N2  - Interferon alpha (IFN-alpha), an important physiological immunomodulator, possesses direct cytotoxic and cytostatic effects on tumour cells, antiangiogenic effects, and activates anti-tumour immunity. Herein the human lung carcinoma cell line A549, a model of NSCLC in vitro, was used to pursue the effect of IFN-alpha on A549 cell proliferation and differentiation together with the effect on protein expression and activity of three ATP-transporters mediating multi-drug resistance (MDR). IFN-alpha significantly inhibited the proliferation of A549 cells which was not connected with arrest in a particular cell cycle phase. IFN-alpha-mediated differentiation of A549 was observed based on an increase in alkaline phosphatase activity. Simultaneously, IFN-alpha increased the expression and activity of ATP-transporters mediating MDR. The IFN-alpha down-regulation of NSCLC cell proliferation was accompanied by a potential of cells to exclude potential therapeutic substances such as chemotherapeutic agents.
ER  -

KREJČOVÁ, Daniela; Jiřina PROCHÁZKOVÁ; Jiří PACHERNÍK a Lukáš KUBALA. Modulation of cell proliferation and differentiation of human lung carcinoma cells by the interferon-alpha. \textit{GENERAL PHYSIOLOGY AND BIOPHYSICS}. 2009, roč.~28, č.~3, 8 s. ISSN~0231-5882.

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