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@article{879427,
author = {Krejčová, Daniela and Procházková, Jiřina and Pacherník, Jiří and Kubala, Lukáš},
article_number = {3},
keywords = {Non-small cell lung cancer; ABC transporter proteins; Cell cycle; Interferons},
language = {eng},
issn = {0231-5882},
journal = {GENERAL PHYSIOLOGY AND BIOPHYSICS},
title = {Modulation of cell proliferation and differentiation of human lung carcinoma cells by the interferon-alpha},
volume = {28},
year = {2009}
}
TY - JOUR
ID - 879427
AU - Krejčová, Daniela - Procházková, Jiřina - Pacherník, Jiří - Kubala, Lukáš
PY - 2009
TI - Modulation of cell proliferation and differentiation of human lung carcinoma cells by the interferon-alpha
JF - GENERAL PHYSIOLOGY AND BIOPHYSICS
VL - 28
IS - 3
SN - 02315882
KW - Non-small cell lung cancer
KW - ABC transporter proteins
KW - Cell cycle
KW - Interferons
N2 - Interferon alpha (IFN-alpha), an important physiological immunomodulator, possesses direct cytotoxic and cytostatic effects on tumour cells, antiangiogenic effects, and activates anti-tumour immunity. Herein the human lung carcinoma cell line A549, a model of NSCLC in vitro, was used to pursue the effect of IFN-alpha on A549 cell proliferation and differentiation together with the effect on protein expression and activity of three ATP-transporters mediating multi-drug resistance (MDR). IFN-alpha significantly inhibited the proliferation of A549 cells which was not connected with arrest in a particular cell cycle phase. IFN-alpha-mediated differentiation of A549 was observed based on an increase in alkaline phosphatase activity. Simultaneously, IFN-alpha increased the expression and activity of ATP-transporters mediating MDR. The IFN-alpha down-regulation of NSCLC cell proliferation was accompanied by a potential of cells to exclude potential therapeutic substances such as chemotherapeutic agents.
ER -
KREJČOVÁ, Daniela, Jiřina PROCHÁZKOVÁ, Jiří PACHERNÍK a Lukáš KUBALA. Modulation of cell proliferation and differentiation of human lung carcinoma cells by the interferon-alpha. \textit{GENERAL PHYSIOLOGY AND BIOPHYSICS}. 2009, roč.~28, č.~3, 8 s. ISSN~0231-5882.
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