Drug efflux transporters, MRP1 and BCRP, affect the outcome of
hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma
cells

J 2009

Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells

JENDZELOVSKY, Rastislav; Jaromir MIKES; Jan KOVAL; Karel SOUČEK; Jiřina PROCHÁZKOVÁ et al.

Základní údaje

Originální název

Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells

Autoři

JENDZELOVSKY, Rastislav; Jaromir MIKES; Jan KOVAL; Karel SOUČEK; Jiřina PROCHÁZKOVÁ; Martin KELLO; Veronika SACKOVA; Jiřina HOFMANOVÁ; Alois KOZUBÍK a Peter FEDOROČKO

Vydání

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 2009, 1474-905X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.708

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/09:00039943

Organizační jednotka

Přírodovědecká fakulta

UT WoS

000272142300010

Klíčová slova anglicky

MULTIDRUG-RESISTANCE; P-GLYCOPROTEIN; JOHNS-WORT; MXR ABCG2; METABOLISM; TOXICITY; INHIBITORS; INDUCTION; MODULATION; EXPRESSION

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 4. 2010 14:02, Mgr. Jiřina Medalová, Ph.D.

Anotace

V originále

Photodynamic therapy (PDT) is a flexible multi-target therapeutic approach. Mechanisms of anticancer drug elimination by tumour cells are mostly linked to the elevated expression and activity of P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1), breast cancer resistance protein (BCRP) and P450 monooxygenases. We report here for the first time increased activity of MRP1 and BCRP in HT-29 colon cancer cells treated with hypericin per se. On the contrary, pre-treatment with proadifen (SKF525A) affected the function of MRP1 and BCRP leading to increased hypericin content, which might indicate a possible link between proadifen and these ABC transporter proteins. Subsequent enhanced intracellular oxidative stress was accompanied by loss of mitochondrial membrane potential, activation of caspase-9 and -3, PARP cleavage and onset of apoptosis.

Citovat

JENDZELOVSKY, Rastislav; Jaromir MIKES; Jan KOVAL; Karel SOUČEK; Jiřina PROCHÁZKOVÁ; Martin KELLO; Veronika SACKOVA; Jiřina HOFMANOVÁ; Alois KOZUBÍK a Peter FEDOROČKO. Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells. PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES. 2009, roč. 8, č. 12, 8 s. ISSN 1474-905X.

@article{879431,
   author = {Jendzelovsky, Rastislav and Mikes, Jaromir and Koval, Jan and Souček, Karel and Procházková, Jiřina and Kello, Martin and Sackova, Veronika and Hofmanová, Jiřina and Kozubík, Alois and Fedoročko, Peter},
   article_number = {12},
   keywords = {MULTIDRUG-RESISTANCE; P-GLYCOPROTEIN; JOHNS-WORT; MXR ABCG2; METABOLISM; TOXICITY; INHIBITORS; INDUCTION; MODULATION; EXPRESSION},
   language = {eng},
   issn = {1474-905X},
   journal = {PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES},
   title = {Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells},
   volume = {8},
   year = {2009}
}

TY  - JOUR
ID  - 879431
AU  - Jendzelovsky, Rastislav - Mikes, Jaromir - Koval, Jan - Souček, Karel - Procházková, Jiřina - Kello, Martin - Sackova, Veronika - Hofmanová, Jiřina - Kozubík, Alois - Fedoročko, Peter
PY  - 2009
TI  - Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells
JF  - PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
VL  - 8
IS  - 12
SN  - 1474905X
KW  - MULTIDRUG-RESISTANCE
KW  - P-GLYCOPROTEIN
KW  - JOHNS-WORT
KW  - MXR ABCG2
KW  - METABOLISM
KW  - TOXICITY
KW  - INHIBITORS
KW  - INDUCTION
KW  - MODULATION
KW  - EXPRESSION
N2  - Photodynamic therapy (PDT) is a flexible multi-target therapeutic approach. Mechanisms of anticancer drug elimination by tumour cells are mostly linked to the elevated expression and activity of P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1), breast cancer resistance protein (BCRP) and P450 monooxygenases. We report here for the first time increased activity of MRP1 and BCRP in HT-29 colon cancer cells treated with hypericin per se. On the contrary, pre-treatment with proadifen (SKF525A) affected the function of MRP1 and BCRP leading to increased hypericin content, which might indicate a possible link between proadifen and these ABC transporter proteins. Subsequent enhanced intracellular oxidative stress was accompanied by loss of mitochondrial membrane potential, activation of caspase-9 and -3, PARP cleavage and onset of apoptosis.
ER  -

JENDZELOVSKY, Rastislav; Jaromir MIKES; Jan KOVAL; Karel SOUČEK; Jiřina PROCHÁZKOVÁ; Martin KELLO; Veronika SACKOVA; Jiřina HOFMANOVÁ; Alois KOZUBÍK a Peter FEDOROČKO. Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells. \textit{PHOTOCHEMICAL \&{} PHOTOBIOLOGICAL SCIENCES}. 2009, roč.~8, č.~12, 8 s. ISSN~1474-905X.

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