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@article{879431,
author = {Jendzelovsky, Rastislav and Mikes, Jaromir and Koval, Jan and Souček, Karel and Procházková, Jiřina and Kello, Martin and Sackova, Veronika and Hofmanová, Jiřina and Kozubík, Alois and Fedoročko, Peter},
article_number = {12},
keywords = {MULTIDRUG-RESISTANCE; P-GLYCOPROTEIN; JOHNS-WORT; MXR ABCG2; METABOLISM; TOXICITY; INHIBITORS; INDUCTION; MODULATION; EXPRESSION},
language = {eng},
issn = {1474-905X},
journal = {PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES},
title = {Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells},
volume = {8},
year = {2009}
}
TY - JOUR
ID - 879431
AU - Jendzelovsky, Rastislav - Mikes, Jaromir - Koval, Jan - Souček, Karel - Procházková, Jiřina - Kello, Martin - Sackova, Veronika - Hofmanová, Jiřina - Kozubík, Alois - Fedoročko, Peter
PY - 2009
TI - Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells
JF - PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
VL - 8
IS - 12
SN - 1474905X
KW - MULTIDRUG-RESISTANCE
KW - P-GLYCOPROTEIN
KW - JOHNS-WORT
KW - MXR ABCG2
KW - METABOLISM
KW - TOXICITY
KW - INHIBITORS
KW - INDUCTION
KW - MODULATION
KW - EXPRESSION
N2 - Photodynamic therapy (PDT) is a flexible multi-target therapeutic approach. Mechanisms of anticancer drug elimination by tumour cells are mostly linked to the elevated expression and activity of P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1), breast cancer resistance protein (BCRP) and P450 monooxygenases. We report here for the first time increased activity of MRP1 and BCRP in HT-29 colon cancer cells treated with hypericin per se. On the contrary, pre-treatment with proadifen (SKF525A) affected the function of MRP1 and BCRP leading to increased hypericin content, which might indicate a possible link between proadifen and these ABC transporter proteins. Subsequent enhanced intracellular oxidative stress was accompanied by loss of mitochondrial membrane potential, activation of caspase-9 and -3, PARP cleavage and onset of apoptosis.
ER -
JENDZELOVSKY, Rastislav, Jaromir MIKES, Jan KOVAL, Karel SOUČEK, Jiřina PROCHÁZKOVÁ, Martin KELLO, Veronika SACKOVA, Jiřina HOFMANOVÁ, Alois KOZUBÍK a Peter FEDOROČKO. Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells. \textit{PHOTOCHEMICAL \&{} PHOTOBIOLOGICAL SCIENCES}. roč.~8, č.~12, 8 s. ISSN~1474-905X. 2009.
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