Drug efflux transporters, MRP1 and BCRP, affect the outcome of
hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma
cells

J 2009

Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells

JENDZELOVSKY, Rastislav, Jaromir MIKES, Jan KOVAL, Karel SOUČEK, Jiřina PROCHÁZKOVÁ et. al.

Základní údaje

Originální název

Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells

Autoři

JENDZELOVSKY, Rastislav (703 Slovensko), Jaromir MIKES (703 Slovensko), Jan KOVAL (703 Slovensko), Karel SOUČEK (203 Česká republika), Jiřina PROCHÁZKOVÁ (203 Česká republika), Martin KELLO (703 Slovensko), Veronika SACKOVA (703 Slovensko), Jiřina HOFMANOVÁ (203 Česká republika), Alois KOZUBÍK (203 Česká republika, garant) a Peter FEDOROČKO (703 Slovensko)

Vydání

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 2009, 1474-905X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.708

Kód RIV

RIV/00216224:14310/09:00039943

Organizační jednotka

Přírodovědecká fakulta

UT WoS

000272142300010

Klíčová slova anglicky

MULTIDRUG-RESISTANCE; P-GLYCOPROTEIN; JOHNS-WORT; MXR ABCG2; METABOLISM; TOXICITY; INHIBITORS; INDUCTION; MODULATION; EXPRESSION

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 4. 2010 14:02, Mgr. Jiřina Medalová, Ph.D.

Anotace

V originále

Photodynamic therapy (PDT) is a flexible multi-target therapeutic approach. Mechanisms of anticancer drug elimination by tumour cells are mostly linked to the elevated expression and activity of P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1), breast cancer resistance protein (BCRP) and P450 monooxygenases. We report here for the first time increased activity of MRP1 and BCRP in HT-29 colon cancer cells treated with hypericin per se. On the contrary, pre-treatment with proadifen (SKF525A) affected the function of MRP1 and BCRP leading to increased hypericin content, which might indicate a possible link between proadifen and these ABC transporter proteins. Subsequent enhanced intracellular oxidative stress was accompanied by loss of mitochondrial membrane potential, activation of caspase-9 and -3, PARP cleavage and onset of apoptosis.

Citovat

JENDZELOVSKY, Rastislav, Jaromir MIKES, Jan KOVAL, Karel SOUČEK, Jiřina PROCHÁZKOVÁ, Martin KELLO, Veronika SACKOVA, Jiřina HOFMANOVÁ, Alois KOZUBÍK a Peter FEDOROČKO. Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells. PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES. 2009, roč. 8, č. 12, 8 s. ISSN 1474-905X.

@article{879431,
   author = {Jendzelovsky, Rastislav and Mikes, Jaromir and Koval, Jan and Souček, Karel and Procházková, Jiřina and Kello, Martin and Sackova, Veronika and Hofmanová, Jiřina and Kozubík, Alois and Fedoročko, Peter},
   article_number = {12},
   keywords = {MULTIDRUG-RESISTANCE; P-GLYCOPROTEIN; JOHNS-WORT; MXR ABCG2; METABOLISM; TOXICITY; INHIBITORS; INDUCTION; MODULATION; EXPRESSION},
   language = {eng},
   issn = {1474-905X},
   journal = {PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES},
   title = {Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells},
   volume = {8},
   year = {2009}
}

TY  - JOUR
ID  - 879431
AU  - Jendzelovsky, Rastislav - Mikes, Jaromir - Koval, Jan - Souček, Karel - Procházková, Jiřina - Kello, Martin - Sackova, Veronika - Hofmanová, Jiřina - Kozubík, Alois - Fedoročko, Peter
PY  - 2009
TI  - Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells
JF  - PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
VL  - 8
IS  - 12
SN  - 1474905X
KW  - MULTIDRUG-RESISTANCE
KW  - P-GLYCOPROTEIN
KW  - JOHNS-WORT
KW  - MXR ABCG2
KW  - METABOLISM
KW  - TOXICITY
KW  - INHIBITORS
KW  - INDUCTION
KW  - MODULATION
KW  - EXPRESSION
N2  - Photodynamic therapy (PDT) is a flexible multi-target therapeutic approach. Mechanisms of anticancer drug elimination by tumour cells are mostly linked to the elevated expression and activity of P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1), breast cancer resistance protein (BCRP) and P450 monooxygenases. We report here for the first time increased activity of MRP1 and BCRP in HT-29 colon cancer cells treated with hypericin per se. On the contrary, pre-treatment with proadifen (SKF525A) affected the function of MRP1 and BCRP leading to increased hypericin content, which might indicate a possible link between proadifen and these ABC transporter proteins. Subsequent enhanced intracellular oxidative stress was accompanied by loss of mitochondrial membrane potential, activation of caspase-9 and -3, PARP cleavage and onset of apoptosis.
ER  -

JENDZELOVSKY, Rastislav, Jaromir MIKES, Jan KOVAL, Karel SOUČEK, Jiřina PROCHÁZKOVÁ, Martin KELLO, Veronika SACKOVA, Jiřina HOFMANOVÁ, Alois KOZUBÍK a Peter FEDOROČKO. Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells. \textit{PHOTOCHEMICAL \&{} PHOTOBIOLOGICAL SCIENCES}. 2009, roč.~8, č.~12, 8 s. ISSN~1474-905X.

Podrobný výpis o publikaci