ZIEBANDT, Anne-Kathrin, Harald KUSCH, Marco DEGNER, Sarah JAGLITZ, Mark J. J. B. SIBBALD, Jan P. ARENDS, Monika A. CHLEBOWICZ, Dirk ALBRECHT, Roman PANTŮČEK, Jiří DOŠKAŘ, Wilma ZIEBUHR, Barbara M. BRÖKER, Michael HECKER, Jan Maarten VAN DIJL a Susanne ENGELMANN. Proteomics uncovers extreme heterogeneity in the Staphylococcus aureus exoproteome due to genomic plasticity and variant gene regulation. Proteomics. Weinheim: Wiley-VCH, 2010, roč. 10, č. 8, s. 1634-1644. ISSN 1615-9853. |
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@article{886928, author = {Ziebandt, AnneandKathrin and Kusch, Harald and Degner, Marco and Jaglitz, Sarah and Sibbald, Mark J. J. B. and Arends, Jan P. and Chlebowicz, Monika A. and Albrecht, Dirk and Pantůček, Roman and Doškař, Jiří and Ziebuhr, Wilma and Bröker, Barbara M. and Hecker, Michael and van Dijl, Jan Maarten and Engelmann, Susanne}, article_location = {Weinheim}, article_number = {8}, keywords = {Exoproteome; Microbiology; Protein secretion; Staphylococcus; TOXIC-SHOCK-SYNDROME; METHICILLIN-RESISTANT; BACILLUS-SUBTILIS; SIGNAL-TRANSDUCTION; VIRULENCE FACTORS; NASAL CARRIAGE}, language = {eng}, issn = {1615-9853}, journal = {Proteomics}, title = {Proteomics uncovers extreme heterogeneity in the Staphylococcus aureus exoproteome due to genomic plasticity and variant gene regulation}, url = {http://www3.interscience.wiley.com/journal/123299148/abstract}, volume = {10}, year = {2010} }
TY - JOUR ID - 886928 AU - Ziebandt, Anne-Kathrin - Kusch, Harald - Degner, Marco - Jaglitz, Sarah - Sibbald, Mark J. J. B. - Arends, Jan P. - Chlebowicz, Monika A. - Albrecht, Dirk - Pantůček, Roman - Doškař, Jiří - Ziebuhr, Wilma - Bröker, Barbara M. - Hecker, Michael - van Dijl, Jan Maarten - Engelmann, Susanne PY - 2010 TI - Proteomics uncovers extreme heterogeneity in the Staphylococcus aureus exoproteome due to genomic plasticity and variant gene regulation JF - Proteomics VL - 10 IS - 8 SP - 1634-1644 EP - 1634-1644 PB - Wiley-VCH SN - 16159853 KW - Exoproteome KW - Microbiology KW - Protein secretion KW - Staphylococcus KW - TOXIC-SHOCK-SYNDROME KW - METHICILLIN-RESISTANT KW - BACILLUS-SUBTILIS KW - SIGNAL-TRANSDUCTION KW - VIRULENCE FACTORS KW - NASAL CARRIAGE UR - http://www3.interscience.wiley.com/journal/123299148/abstract N2 - Sequencing of at least 13 Staphylococcus aureus isolates has shown that genomic plasticity impacts significantly on the repertoire of virulence factors. However, genome sequencing does not reveal which genes are expressed by individual isolates. Here, we have therefore performed a comprehensive survey of the composition and variability of the S. aureus exoproteome. This involved multilocus sequence typing, virulence gene, and prophage profiling by multiplex PCR, and proteomic analyses of secreted proteins using 2-DE. Dissection of the exoproteomes of 25 clinical isolates revealed that only seven out of 63 identified secreted proteins were produced by all isolates, indicating a remarkably high exoproteome heterogeneity within one bacterial species. Most interesting, the observed variations were caused not only by genome plasticity, but also by an unprecedented variation in secretory protein production due to differences in transcriptional and post-transcriptional regulation. Our data imply that genomic studies on virulence gene conservation patterns need to be complemented by analyses of the extracellular protein pattern to assess the full virulence potential of bacterial pathogens like S. aureus. Importantly, the extensive variability of secreted virulence factors in S. aureus also suggests that development of protective vaccines against this pathogen requires a carefully selected combination of invariably produced antigens. ER -
ZIEBANDT, Anne-Kathrin, Harald KUSCH, Marco DEGNER, Sarah JAGLITZ, Mark J. J. B. SIBBALD, Jan P. ARENDS, Monika A. CHLEBOWICZ, Dirk ALBRECHT, Roman PANTŮČEK, Jiří DOŠKAŘ, Wilma ZIEBUHR, Barbara M. BRÖKER, Michael HECKER, Jan Maarten VAN DIJL a Susanne ENGELMANN. Proteomics uncovers extreme heterogeneity in the Staphylococcus aureus exoproteome due to genomic plasticity and variant gene regulation. \textit{Proteomics}. Weinheim: Wiley-VCH, 2010, roč.~10, č.~8, s.~1634-1644. ISSN~1615-9853.
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