DNA modifications by antitumor trans-[PtCl2(E-iminoether)(2)]

J 1997

DNA modifications by antitumor trans-[PtCl2(E-iminoether)(2)]

ŽALUDOVÁ, Renata; Alena ŽÁKOVSKÁ; Jana KAŠPÁRKOVÁ; Zdeňka BALCAROVÁ; Oldřich VRÁNA et al.

Základní údaje

Originální název

DNA modifications by antitumor trans-[PtCl2(E-iminoether)(2)]

Autoři

ŽALUDOVÁ, Renata; Alena ŽÁKOVSKÁ; Jana KAŠPÁRKOVÁ; Zdeňka BALCAROVÁ; Oldřich VRÁNA; Mauro COLUCCIA; Giovanni NATILE a Viktor BRABEC

Vydání

MOLECULAR PHARMACOLOGY, 1997, 0026-895X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.921

Označené pro přenos do RIV

Ano

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

INTERSTRAND CROSS-LINKS; ANTI-TUMOR ACTIVITY; PLATINUM COMPLEXES; IN-VITRO; CISPLATIN; BINDING; CIS-DIAMMINEDICHLOROPLATINUM(II); ADDUCTS; CYTOTOXICITY; ANTIBODIES

Změněno: 5. 8. 2010 14:14, RNDr. Kamila Neplechová, Ph.D.

Anotace

V originále

Recent findings that an analogue of clinically ineffective transplatin, trans-[PtCl2(E-iminoether)(2)], exhibits antitumor activity has helped reevaluation of the empirical structure-antitumor activity relationship generally accepted for platinum(II) complexes. According to this relationship, only the cis geometry of leaving ligands in the bifunctional platinum(II) complexes, should be therapeutically active. Global modifications of natural DNAs in cell-free media by trans-[PtCl2(E-iminoether)(2)] were studied through various molecular biophysical methods and compared with modifications by cis-[PtCl2(E-iminoether)(2)], transplatin, cisplatin, and monofunctional chlorodiethylenetriamineplatinum(II) chloride.

Návaznosti

GA204/97/P028, projekt VaV

Název: Biofyzikální analýza vlivu protinádorově účinných komplexů ruthenia na DNA

Citovat

ŽALUDOVÁ, Renata; Alena ŽÁKOVSKÁ; Jana KAŠPÁRKOVÁ; Zdeňka BALCAROVÁ; Oldřich VRÁNA; Mauro COLUCCIA; Giovanni NATILE a Viktor BRABEC. DNA modifications by antitumor trans-[PtCl2(E-iminoether)(2)]. MOLECULAR PHARMACOLOGY. 1997, roč. 52, č. 3, 8 s. ISSN 0026-895X.

@article{893203,
   author = {Žaludová, Renata and Žákovská, Alena and Kašpárková, Jana and Balcarová, Zdeňka and Vrána, Oldřich and Coluccia, Mauro and Natile, Giovanni and Brabec, Viktor},
   article_number = {3},
   keywords = {INTERSTRAND CROSS-LINKS; ANTI-TUMOR ACTIVITY; PLATINUM COMPLEXES; IN-VITRO; CISPLATIN; BINDING; CIS-DIAMMINEDICHLOROPLATINUM(II); ADDUCTS; CYTOTOXICITY; ANTIBODIES},
   language = {eng},
   issn = {0026-895X},
   journal = {MOLECULAR PHARMACOLOGY},
   title = {DNA modifications by antitumor trans-[PtCl2(E-iminoether)(2)]},
   volume = {52},
   year = {1997}
}

TY  - JOUR
ID  - 893203
AU  - Žaludová, Renata - Žákovská, Alena - Kašpárková, Jana - Balcarová, Zdeňka - Vrána, Oldřich - Coluccia, Mauro - Natile, Giovanni - Brabec, Viktor
PY  - 1997
TI  - DNA modifications by antitumor trans-[PtCl2(E-iminoether)(2)]
JF  - MOLECULAR PHARMACOLOGY
VL  - 52
IS  - 3
SN  - 0026895X
KW  - INTERSTRAND CROSS-LINKS
KW  - ANTI-TUMOR ACTIVITY
KW  - PLATINUM COMPLEXES
KW  - IN-VITRO
KW  - CISPLATIN
KW  - BINDING
KW  - CIS-DIAMMINEDICHLOROPLATINUM(II)
KW  - ADDUCTS
KW  - CYTOTOXICITY
KW  - ANTIBODIES
N2  - Recent findings that an analogue of clinically ineffective transplatin, trans-[PtCl2(E-iminoether)(2)], exhibits antitumor activity has helped reevaluation of the empirical structure-antitumor activity relationship generally accepted for platinum(II) complexes. According to this relationship, only the cis geometry of leaving ligands in the bifunctional platinum(II) complexes, should be therapeutically active. Global modifications of natural DNAs in cell-free media by trans-[PtCl2(E-iminoether)(2)] were studied through various molecular biophysical methods and compared with modifications by cis-[PtCl2(E-iminoether)(2)], transplatin, cisplatin, and monofunctional chlorodiethylenetriamineplatinum(II) chloride.
ER  -

ŽALUDOVÁ, Renata; Alena ŽÁKOVSKÁ; Jana KAŠPÁRKOVÁ; Zdeňka BALCAROVÁ; Oldřich VRÁNA; Mauro COLUCCIA; Giovanni NATILE a Viktor BRABEC. DNA modifications by antitumor trans-[PtCl2(E-iminoether)(2)]. \textit{MOLECULAR PHARMACOLOGY}. 1997, roč.~52, č.~3, 8 s. ISSN~0026-895X.

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