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@article{893203,
author = {Žaludová, Renata and Žákovská, Alena and Kašpárková, Jana and Balcarová, Zdeňka and Vrána, Oldřich and Coluccia, Mauro and Natile, Giovanni and Brabec, Viktor},
article_number = {3},
keywords = {INTERSTRAND CROSS-LINKS; ANTI-TUMOR ACTIVITY; PLATINUM COMPLEXES; IN-VITRO; CISPLATIN; BINDING; CIS-DIAMMINEDICHLOROPLATINUM(II); ADDUCTS; CYTOTOXICITY; ANTIBODIES},
language = {eng},
issn = {0026-895X},
journal = {MOLECULAR PHARMACOLOGY},
title = {DNA modifications by antitumor trans-[PtCl2(E-iminoether)(2)]},
volume = {52},
year = {1997}
}
TY - JOUR
ID - 893203
AU - Žaludová, Renata - Žákovská, Alena - Kašpárková, Jana - Balcarová, Zdeňka - Vrána, Oldřich - Coluccia, Mauro - Natile, Giovanni - Brabec, Viktor
PY - 1997
TI - DNA modifications by antitumor trans-[PtCl2(E-iminoether)(2)]
JF - MOLECULAR PHARMACOLOGY
VL - 52
IS - 3
SN - 0026895X
KW - INTERSTRAND CROSS-LINKS
KW - ANTI-TUMOR ACTIVITY
KW - PLATINUM COMPLEXES
KW - IN-VITRO
KW - CISPLATIN
KW - BINDING
KW - CIS-DIAMMINEDICHLOROPLATINUM(II)
KW - ADDUCTS
KW - CYTOTOXICITY
KW - ANTIBODIES
N2 - Recent findings that an analogue of clinically ineffective transplatin, trans-[PtCl2(E-iminoether)(2)], exhibits antitumor activity has helped reevaluation of the empirical structure-antitumor activity relationship generally accepted for platinum(II) complexes. According to this relationship, only the cis geometry of leaving ligands in the bifunctional platinum(II) complexes, should be therapeutically active. Global modifications of natural DNAs in cell-free media by trans-[PtCl2(E-iminoether)(2)] were studied through various molecular biophysical methods and compared with modifications by cis-[PtCl2(E-iminoether)(2)], transplatin, cisplatin, and monofunctional chlorodiethylenetriamineplatinum(II) chloride.
ER -
ŽALUDOVÁ, Renata, Alena ŽÁKOVSKÁ, Jana KAŠPÁRKOVÁ, Zdeňka BALCAROVÁ, Oldřich VRÁNA, Mauro COLUCCIA, Giovanni NATILE a Viktor BRABEC. DNA modifications by antitumor trans-[PtCl2(E-iminoether)(2)]. \textit{MOLECULAR PHARMACOLOGY}. 1997, roč.~52, č.~3, 8 s. ISSN~0026-895X.
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