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@proceedings{895883,
author = {Fialová, Kateřina and Hudecová, Soňa and Sedláková, Barbora and Križanová, Olga and Nováková, Marie},
booktitle = {86. Fyziologické dny},
keywords = {sigma ligand;haloperidol;rat heart;QT interval},
title = {Chronic treatment with haloperidol changes expression of sigma-1 receptor in rat heart.},
year = {2010}
}
TY - CONF
ID - 895883
AU - Fialová, Kateřina - Hudecová, Soňa - Sedláková, Barbora - Križanová, Olga - Nováková, Marie
PY - 2010
TI - Chronic treatment with haloperidol changes expression of sigma-1 receptor in rat heart.
KW - sigma ligand;haloperidol;rat heart;QT interval
N2 - The effects of sigma receptor ligand haloperidol on expression of sigma-1 receptor after three weeks treatment with this drug were studied in individual parts of the heart - both atria and ventricles. The samples were stored at -80C until PCR specific for the sigma-1 receptor was carried out. Cycloidin was used as a housekeeper gene control for semi-quantitative evaluation of PCR. All PCR products were analyzed on 2% agarose gels. Intensity of individual bands was evaluated by measuring the optical density per mm2 and compared relative to CYCLO mRNA.
ER -
FIALOVÁ, Kateřina, Soňa HUDECOVÁ, Barbora SEDLÁKOVÁ, Olga KRIŽANOVÁ a Marie NOVÁKOVÁ. Chronic treatment with haloperidol changes expression of sigma-1 receptor in rat heart. In \textit{86. Fyziologické dny}. 2010. ISSN~0862-8408.
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