Overdiagnosis in breast cancer screening programme in the Czech Republic

BUREŠOVÁ, Lucie; Ondřej MÁJEK; Jan DANEŠ; Helena BARTOŇKOVÁ; Miroslava SKOVAJSOVÁ a Ladislav DUŠEK. Overdiagnosis in breast cancer screening programme in the Czech Republic. In International Cancer Screening Network (ICSN) Biennial Meeting. 2010.

Základní údaje

Originální název

Overdiagnosis in breast cancer screening programme in the Czech Republic

Autoři

BUREŠOVÁ, Lucie; Ondřej MÁJEK ORCID; Jan DANEŠ; Helena BARTOŇKOVÁ; Miroslava SKOVAJSOVÁ a Ladislav DUŠEK

Vydání

International Cancer Screening Network (ICSN) Biennial Meeting, 2010

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Další údaje

Typ výsledku

Prezentace na konferencích

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Ne

Organizační jednotka

Institut biostatistiky a analýz

Příznaky

Mezinárodní význam

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Anotace

V originále

Background: There were 1,611,582 examinations performed in 1,067,836 women attending organized breast cancer screening programme in Czech Republic during period 2002-2007. Total of 7,835 cases of breast cancer were detected. Objective: To estimate the extent of overdiagnosis for different age groups. Methods: Overdiagnosis of ductal carcinoma in situ (DCIS) only was assumed. Certain proportion of DCIS is non-progressive and represents the overdiagnosed tumours. Markov models with variable number of states were used. Simultaneous estimation of lambda1 (transition rate to preclinical screen-detectable phase, where no signs of the disease are present, but it could be detected by mammography), lambda2 (transition rate from preclinical screen-detectable phase to clinical phase) and mi (incidence of overdiagnosed tumours) was performed. Estimation procedure was performed using Bayesian methods implemented in WinBUGS software. Results: The incidence of overdiagnosed tumours was from 3 x 10-6 till 9 x 10-6 according to age group examined and was slightly higher for older women. Conclusion: Overdiagnosis doesn’t seem to be significant problem in organized breast cancer screening programme in the Czech Republic.

Anglicky

Background: There were 1,611,582 examinations performed in 1,067,836 women attending organized breast cancer screening programme in Czech Republic during period 2002-2007. Total of 7,835 cases of breast cancer were detected. Objective: To estimate the extent of overdiagnosis for different age groups. Methods: Overdiagnosis of ductal carcinoma in situ (DCIS) only was assumed. Certain proportion of DCIS is non-progressive and represents the overdiagnosed tumours. Markov models with variable number of states were used. Simultaneous estimation of lambda1 (transition rate to preclinical screen-detectable phase, where no signs of the disease are present, but it could be detected by mammography), lambda2 (transition rate from preclinical screen-detectable phase to clinical phase) and mi (incidence of overdiagnosed tumours) was performed. Estimation procedure was performed using Bayesian methods implemented in WinBUGS software. Results: The incidence of overdiagnosed tumours was from 3 x 10-6 till 9 x 10-6 according to age group examined and was slightly higher for older women. Conclusion: Overdiagnosis doesn’t seem to be significant problem in organized breast cancer screening programme in the Czech Republic.