Association of FcRn expression with lung abnormalities and IVIG
catabolism in patients with common variable immunodeficiency

J 2010

Association of FcRn expression with lung abnormalities and IVIG catabolism in patients with common variable immunodeficiency

FREIBERGER, Tomáš; Lucie GRODECKÁ; Barbora RAVČUKOVÁ; Barbora KUŘECOVÁ; Věra POSTRÁNECKÁ et al.

Základní údaje

Originální název

Association of FcRn expression with lung abnormalities and IVIG catabolism in patients with common variable immunodeficiency

Autoři

FREIBERGER, Tomáš ; Lucie GRODECKÁ; Barbora RAVČUKOVÁ; Barbora KUŘECOVÁ; Věra POSTRÁNECKÁ; Jiří VLČEK; Jiří JARKOVSKÝ ; Vojtěch THON a Jiří LITZMAN

Vydání

CLINICAL IMMUNOLOGY, Elsevier, 2010, 1521-6616

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.932

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/10:00051454

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1016/j.clim.2010.05.006

UT WoS

000280907000011

Klíčová slova anglicky

Neonatal Fc receptor; FcRn; Common variable immunodeficiency; Lung disease; IVIG

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 4. 2013 12:14, prof. MUDr. Vojtěch Thon, Ph.D.

Anotace

V originále

Patients with generalized bronchiectasis and fibrosis had lower levels of FCRN mRNA compared to patients without these complications. Moreover, FCRN mRNA levels correlated negatively with the extent of bronchiectasis and the rate of IgG decline after infusion of IVIG.Our results showed that FcRn might play a role in the development of lung structural abnormalities and in the catabolism of IVIG in patients with CVID.

Citovat

FREIBERGER, Tomáš; Lucie GRODECKÁ; Barbora RAVČUKOVÁ; Barbora KUŘECOVÁ; Věra POSTRÁNECKÁ; Jiří VLČEK; Jiří JARKOVSKÝ; Vojtěch THON a Jiří LITZMAN. Association of FcRn expression with lung abnormalities and IVIG catabolism in patients with common variable immunodeficiency. CLINICAL IMMUNOLOGY. Elsevier, 2010, roč. 136, č. 3, s. 419-425. ISSN 1521-6616. Dostupné z: https://doi.org/10.1016/j.clim.2010.05.006.

@article{897947,
   author = {Freiberger, Tomáš and Grodecká, Lucie and Ravčuková, Barbora and Kuřecová, Barbora and Postránecká, Věra and Vlček, Jiří and Jarkovský, Jiří and Thon, Vojtěch and Litzman, Jiří},
   article_number = {3},
   doi = {https://doi.org/10.1016/j.clim.2010.05.006},
   keywords = {Neonatal Fc receptor; FcRn; Common variable immunodeficiency; Lung disease; IVIG},
   language = {eng},
   issn = {1521-6616},
   journal = {CLINICAL IMMUNOLOGY},
   title = {Association of FcRn expression with lung abnormalities and IVIG catabolism in patients with common variable immunodeficiency},
   volume = {136},
   year = {2010}
}

TY  - JOUR
ID  - 897947
AU  - Freiberger, Tomáš - Grodecká, Lucie - Ravčuková, Barbora - Kuřecová, Barbora - Postránecká, Věra - Vlček, Jiří - Jarkovský, Jiří - Thon, Vojtěch - Litzman, Jiří
PY  - 2010
TI  - Association of FcRn expression with lung abnormalities and IVIG catabolism in patients with common variable immunodeficiency
JF  - CLINICAL IMMUNOLOGY
VL  - 136
IS  - 3
SP  - 419-425
EP  - 419-425
PB  - Elsevier
SN  - 15216616
KW  - Neonatal Fc receptor
KW  - FcRn
KW  - Common variable immunodeficiency
KW  - Lung disease
KW  - IVIG
N2  - Patients with generalized bronchiectasis and fibrosis had lower levels of FCRN mRNA compared to patients without these complications. Moreover, FCRN mRNA levels correlated negatively with the extent of bronchiectasis and the rate of IgG decline after infusion of IVIG.Our results showed that FcRn might play a role in the development of lung structural abnormalities and in the catabolism of IVIG in patients with CVID.
ER  -

FREIBERGER, Tomáš; Lucie GRODECKÁ; Barbora RAVČUKOVÁ; Barbora KUŘECOVÁ; Věra POSTRÁNECKÁ; Jiří VLČEK; Jiří JARKOVSKÝ; Vojtěch THON a Jiří LITZMAN. Association of FcRn expression with lung abnormalities and IVIG catabolism in patients with common variable immunodeficiency. \textit{CLINICAL IMMUNOLOGY}. Elsevier, 2010, roč.~136, č.~3, s.~419-425. ISSN~1521-6616. Dostupné z: https://doi.org/10.1016/j.clim.2010.05.006.

Přehled o publikaci