The production of mannan-binding lectin is dependent upon
thyroid hormones regardless of the genotype: A cohort study of
95 patients with autoimmune thyroid disorders

J 2010

The production of mannan-binding lectin is dependent upon thyroid hormones regardless of the genotype: A cohort study of 95 patients with autoimmune thyroid disorders

POTLUKOVA, Eliška; Jan JISKRA; Tomáš FREIBERGER; Zdenka LIMANOVA; Dana ZIVOROVA et al.

Základní údaje

Originální název

The production of mannan-binding lectin is dependent upon thyroid hormones regardless of the genotype: A cohort study of 95 patients with autoimmune thyroid disorders

Autoři

Vydání

CLINICAL IMMUNOLOGY, Elsevier, 2010, 1521-6616

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.932

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/10:00040792

Organizační jednotka

Lékařská fakulta

UT WoS

000278954300013

Klíčová slova anglicky

Mannan-binding lectin; Complement; Autoimmune thyroid disorders; Graves' disease; Hashimoto's thyroiditis

Změněno: 16. 1. 2011 00:05, prof. MUDr. Tomáš Freiberger, Ph.D.

Anotace

V originále

Serum levels of MBL and parameters of the thyroid function were determined in 62 patients with Hashimoto's thyroiditis, 33 with Graves' disease and 47 blood donors. Follow-up measurements were performed after 6 to 24 months. MBL2 genotypes were determined using multiplex PCR and compared to 359 healthy Czech individuals. Serum levels of MBL tightly correlated with thyroid hormones, leading to strongly increased MBL levels in hyperthyroidism and decreased levels in hypothyroidism. With normalization of the thyroid function during follow-up, MBL levels decreased or increased respectively. The observed correlations were not due to MBL polymorphisms since the frequency of MBL2 polymorphisms in AITD patients was not different from the general population. We conclude that AITD are not associated with MBL polymorphisms. However, the MBL production is strongly dependent on thyroid function, regardless of the genotype.

Návaznosti

NS10662, projekt VaV

Název: Komplement v etiopatogenezi autoimunitních tyreopatií

Citovat

POTLUKOVA, Eliška; Jan JISKRA; Tomáš FREIBERGER; Zdenka LIMANOVA; Dana ZIVOROVA; Karin MALICKOVA; Drahomira SPRINGER; Lucie GRODECKÁ; Marie ANTOSOVA; Zdenek TELICKA; Satu SINIKKA PESICKOVA a Marten TRENDELENBURG. The production of mannan-binding lectin is dependent upon thyroid hormones regardless of the genotype: A cohort study of 95 patients with autoimmune thyroid disorders. CLINICAL IMMUNOLOGY. Elsevier, 2010, roč. 2010, č. 136, s. 123-9, 7 s. ISSN 1521-6616.

@article{897950,
   author = {Potlukova, Eliška and Jiskra, Jan and Freiberger, Tomáš and Limanova, Zdenka and Zivorova, Dana and Malickova, Karin and Springer, Drahomira and Grodecká, Lucie and Antosova, Marie and Telicka, Zdenek and Sinikka Pesickova, Satu and Trendelenburg, Marten},
   article_number = {136},
   keywords = {Mannan-binding lectin; Complement; Autoimmune thyroid disorders; Graves' disease; Hashimoto's thyroiditis},
   language = {eng},
   issn = {1521-6616},
   journal = {CLINICAL IMMUNOLOGY},
   title = {The production of mannan-binding lectin is dependent upon thyroid hormones regardless of the genotype: A cohort study of 95 patients with autoimmune thyroid disorders},
   volume = {roč. 2010},
   year = {2010}
}

TY  - JOUR
ID  - 897950
AU  - Potlukova, Eliška - Jiskra, Jan - Freiberger, Tomáš - Limanova, Zdenka - Zivorova, Dana - Malickova, Karin - Springer, Drahomira - Grodecká, Lucie - Antosova, Marie - Telicka, Zdenek - Sinikka Pesickova, Satu - Trendelenburg, Marten
PY  - 2010
TI  - The production of mannan-binding lectin is dependent upon thyroid hormones regardless of the genotype: A cohort study of 95 patients with autoimmune thyroid disorders
JF  - CLINICAL IMMUNOLOGY
VL  - roč. 2010
IS  - 136
SP  - 123-9
EP  - 123-9
PB  - Elsevier
SN  - 15216616
KW  - Mannan-binding lectin
KW  - Complement
KW  - Autoimmune thyroid disorders
KW  - Graves' disease
KW  - Hashimoto's thyroiditis
N2  - Serum levels of MBL and parameters of the thyroid function were determined in 62 patients with Hashimoto's thyroiditis, 33 with Graves' disease and 47 blood donors. Follow-up measurements were performed after 6 to 24 months. MBL2 genotypes were determined using multiplex PCR and compared to 359 healthy Czech individuals. Serum levels of MBL tightly correlated with thyroid hormones, leading to strongly increased MBL levels in hyperthyroidism and decreased levels in hypothyroidism. With normalization of the thyroid function during follow-up, MBL levels decreased or increased respectively. The observed correlations were not due to MBL polymorphisms since the frequency of MBL2 polymorphisms in AITD patients was not different from the general population. We conclude that AITD are not associated with MBL polymorphisms. However, the MBL production is strongly dependent on thyroid function, regardless of the genotype.
ER  -

POTLUKOVA, Eliška; Jan JISKRA; Tomáš FREIBERGER; Zdenka LIMANOVA; Dana ZIVOROVA; Karin MALICKOVA; Drahomira SPRINGER; Lucie GRODECKÁ; Marie ANTOSOVA; Zdenek TELICKA; Satu SINIKKA PESICKOVA a Marten TRENDELENBURG. The production of mannan-binding lectin is dependent upon thyroid hormones regardless of the genotype: A cohort study of 95 patients with autoimmune thyroid disorders. \textit{CLINICAL IMMUNOLOGY}. Elsevier, 2010, roč. 2010, č.~136, s.~123-9, 7 s. ISSN~1521-6616.

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