Association of polymorphisms in interleukin-10 gene promoter
with autoantibody production in patients with rheumatoid
arthritis.

J 2010

Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis.

NĚMEC, Petr; MP GOLDBERGOVA; Jiřina GATTEROVA; Anna VAŠKŮ; Miroslav SOUČEK et al.

Základní údaje

Originální název

Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis.

Autoři

NĚMEC, Petr; MP GOLDBERGOVA; Jiřina GATTEROVA; Anna VAŠKŮ a Miroslav SOUČEK

Vydání

Ann N Y Acad Sci, New York, USA, New York Academy of Sciences, 2010, 0077-8923

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.847

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/10:00040797

Organizační jednotka

Lékařská fakulta

UT WoS

000270762800070

Klíčová slova anglicky

gene; RA; promoter; IL10; polymorphism

Změněno: 19. 1. 2011 15:21, prof. MUDr. Miroslav Souček, CSc.

Anotace

V originále

Interleukin-10 (IL-10) is a major anti-inflammatory cytokine that plays a crucial role in the regulation of the immune system. Allelic polymorphisms in the IL-10 gene promoter may contribute to the regulation of autoantibody production. To examine the association between both individuals IL-10 single nucleotide polymorphisms and the production of autoantibodies and the radiographic progression of rheumatoid arthritis (RA), a total of 144 RA patients were recruited into the study. We found significant differences in genotype distribution of the -1082G/A polymorphism between IgG, IgA, and IgM rheumatoid factor(RF)-positive/negative RA patients. We also found significant differences in allelic frequencies of the -3575T/A, -819C/T, and -592A/C polymorphisms between anticyclic citrullinated peptide (anti-CCP)-positive/negative RA patients. The haplotype TGAATA was found to be less frequent within anti-CCP-positive RA patients. Results obtained in this study provide evidence of an association between polymorphisms in IL-10 gene promoter and the production of autoantibodies in RA patients.

Návaznosti

NR7812, projekt VaV

Název: Genetická variabilita pro- a proti-zánětlivých cytokinů v patogenezi revmatoidní artritidy

Investor: Ministerstvo zdravotnictví ČR, Genetická variabilita pro- a proti-zánětlivých cytokinů v patogenezi revmatoidní artridity

Citovat

NĚMEC, Petr; MP GOLDBERGOVA; Jiřina GATTEROVA; Anna VAŠKŮ a Miroslav SOUČEK. Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis. Ann N Y Acad Sci. New York, USA: New York Academy of Sciences, 2010, roč. 1173, Sept, 8 s. ISSN 0077-8923.

@article{900500,
   author = {Němec, Petr and Goldbergova, MP and Gatterova, Jiřina and Vašků, Anna and Souček, Miroslav},
   article_location = {New York, USA},
   article_number = {Sept},
   keywords = {gene; RA; promoter; IL10; polymorphism},
   language = {eng},
   issn = {0077-8923},
   journal = {Ann N Y Acad Sci},
   title = {Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis.},
   volume = {1173},
   year = {2010}
}

TY  - JOUR
ID  - 900500
AU  - Němec, Petr - Goldbergova, MP - Gatterova, Jiřina - Vašků, Anna - Souček, Miroslav
PY  - 2010
TI  - Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis.
JF  - Ann N Y Acad Sci
VL  - 1173
IS  - Sept
PB  - New York Academy of Sciences
SN  - 00778923
KW  - gene
KW  - RA
KW  - promoter
KW  - IL10
KW  - polymorphism
N2  - Interleukin-10 (IL-10) is a major anti-inflammatory cytokine that plays a crucial role in the regulation of the immune system. Allelic polymorphisms in the IL-10 gene promoter may contribute to the regulation of autoantibody production. To examine the association between both individuals IL-10 single nucleotide polymorphisms and the production of autoantibodies and the radiographic progression of rheumatoid arthritis (RA), a total of 144 RA patients were recruited into the study. We found significant differences in genotype distribution of the -1082G/A polymorphism between IgG, IgA, and IgM rheumatoid factor(RF)-positive/negative RA patients. We also found significant differences in allelic frequencies of the -3575T/A, -819C/T, and -592A/C polymorphisms between anticyclic citrullinated peptide (anti-CCP)-positive/negative RA patients. The haplotype TGAATA was found to be less frequent within anti-CCP-positive RA patients. Results obtained in this study provide evidence of an association between polymorphisms in IL-10 gene promoter and the production of autoantibodies in RA patients.
ER  -

NĚMEC, Petr; MP GOLDBERGOVA; Jiřina GATTEROVA; Anna VAŠKŮ a Miroslav SOUČEK. Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis. \textit{Ann N Y Acad Sci}. New York, USA: New York Academy of Sciences, 2010, roč.~1173, Sept, 8 s. ISSN~0077-8923.

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