Association of the -1082 G/A promoter polymorphism of
interleukin-10 gene with the autoantibodies production in
patients with rheumatoid arthritis.

J 2009

Association of the -1082 G/A promoter polymorphism of interleukin-10 gene with the autoantibodies production in patients with rheumatoid arthritis.

NĚMEC, Petr; Goldbergova M PAVKOVA; Jiřina GATTEROVA; Zdeněk FOJTÍK; Anna VAŠKŮ et al.

Základní údaje

Originální název

Association of the -1082 G/A promoter polymorphism of interleukin-10 gene with the autoantibodies production in patients with rheumatoid arthritis.

Autoři

NĚMEC, Petr; Goldbergova M PAVKOVA; Jiřina GATTEROVA; Zdeněk FOJTÍK; Anna VAŠKŮ a Miroslav SOUČEK

Vydání

Clin. Rheumatol, 2009, 0770-3198

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.668

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/09:00040798

Organizační jednotka

Lékařská fakulta

UT WoS

000268102100005

Klíčová slova anglicky

gene; polymorphism; IL10

Změněno: 1. 10. 2010 13:36, prof. RNDr. Monika Pávková Goldbergová, Ph.D.

Anotace

V originále

Interleukin-10 (IL-10) is an immunoregulatory cytokine, usually considered to mediate the downregulation of the inflammatory response in rheumatoid arthritis (RA). Some effects of IL-10 are not anti-inflammatory; for example, the activation of B cells to promote autoantibody production. Allelic polymorphisms located in the promoter region of the IL-10 gene may contribute to the regulation of autoantibodies production. To examine the putative association between the -1082 G/A polymorphism in the promoter region of the IL-10 gene and the susceptibility to disease onset and severity of RA, a total of 144 patients with RA diagnosed according to the revised criteria of the American College of Rheumatology for RA were consecutively recruited into the study. Radiographic progression of RA was scored according to the Sharp/van der Heijde method. Serum levels of rheumatoid factors (RFs) were measured by enzyme-linked immunosorbent assay. Polymerase chain reaction amplification was used for the analysis of the promoter polymorphism of the IL-10 gene. We observed significant differences in genotype distribution of the -1082 G/A polymorphism between IgM RF, IgA RF, and IgG RF positive/negative subgroups of RA patients, with higher prevalence of the GG genotype within IgM RF (Pg = 0.006), IgA RF (Pg = 0.05), and IgG RF (Pg = 0.007) negative RA patients. Results obtained in this study provide the evidence of an association between the -1082 G/A polymorphism in the IL-10 gene promoter and the production of RFs in RA patients.

Návaznosti

NR7812, projekt VaV

Název: Genetická variabilita pro- a proti-zánětlivých cytokinů v patogenezi revmatoidní artritidy

Investor: Ministerstvo zdravotnictví ČR, Genetická variabilita pro- a proti-zánětlivých cytokinů v patogenezi revmatoidní artridity

Citovat

NĚMEC, Petr; Goldbergova M PAVKOVA; Jiřina GATTEROVA; Zdeněk FOJTÍK; Anna VAŠKŮ a Miroslav SOUČEK. Association of the -1082 G/A promoter polymorphism of interleukin-10 gene with the autoantibodies production in patients with rheumatoid arthritis. Clin. Rheumatol. 2009, roč. 8, č. 28, 7 s. ISSN 0770-3198.

@article{900504,
   author = {Němec, Petr and Pavkova, Goldbergova M and Gatterova, Jiřina and Fojtík, Zdeněk and Vašků, Anna and Souček, Miroslav},
   article_number = {28},
   keywords = {gene; polymorphism; IL10},
   language = {eng},
   issn = {0770-3198},
   journal = {Clin. Rheumatol},
   title = {Association of the -1082 G/A promoter polymorphism of interleukin-10 gene with the autoantibodies production in patients with rheumatoid arthritis.},
   volume = {8},
   year = {2009}
}

TY  - JOUR
ID  - 900504
AU  - Němec, Petr - Pavkova, Goldbergova M - Gatterova, Jiřina - Fojtík, Zdeněk - Vašků, Anna - Souček, Miroslav
PY  - 2009
TI  - Association of the -1082 G/A promoter polymorphism of interleukin-10 gene with the autoantibodies production in patients with rheumatoid arthritis.
JF  - Clin. Rheumatol
VL  - 8
IS  - 28
SN  - 07703198
KW  - gene
KW  - polymorphism
KW  - IL10
N2  - Interleukin-10 (IL-10) is an immunoregulatory cytokine, usually considered to mediate the downregulation of the inflammatory response in rheumatoid arthritis (RA). Some effects of IL-10 are not anti-inflammatory; for example, the activation of B cells to promote autoantibody production. Allelic polymorphisms located in the promoter region of the IL-10 gene may contribute to the regulation of autoantibodies production. To examine the putative association between the -1082 G/A polymorphism in the promoter region of the IL-10 gene and the susceptibility to disease onset and severity of RA, a total of 144 patients with RA diagnosed according to the revised criteria of the American College of Rheumatology for RA were consecutively recruited into the study. Radiographic progression of RA was scored according to the Sharp/van der Heijde method. Serum levels of rheumatoid factors (RFs) were measured by enzyme-linked immunosorbent assay. Polymerase chain reaction amplification was used for the analysis of the promoter polymorphism of the IL-10 gene. We observed significant differences in genotype distribution of the -1082 G/A polymorphism between IgM RF, IgA RF, and IgG RF positive/negative subgroups of RA patients, with higher prevalence of the GG genotype within IgM RF (Pg = 0.006), IgA RF (Pg = 0.05), and IgG RF (Pg = 0.007) negative RA patients. Results obtained in this study provide the evidence of an association between the -1082 G/A polymorphism in the IL-10 gene promoter and the production of RFs in RA patients.
ER  -

NĚMEC, Petr; Goldbergova M PAVKOVA; Jiřina GATTEROVA; Zdeněk FOJTÍK; Anna VAŠKŮ a Miroslav SOUČEK. Association of the -1082 G/A promoter polymorphism of interleukin-10 gene with the autoantibodies production in patients with rheumatoid arthritis. \textit{Clin. Rheumatol}. 2009, roč.~8, č.~28, 7 s. ISSN~0770-3198.

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