Další formáty:
BibTeX
LaTeX
RIS
@article{900508, author = {Pávková Goldbergová, Monika and Špinarová, Lenka and Špinar, Jindřich and Vítovec, Jiří and Pařenica, Jiří and Poloczek, Martin and Vašků, Anna}, article_number = {5}, keywords = {gene; polymorphism; rxr; blood group}, language = {eng}, issn = {1895-104X}, journal = {Cent. Eur. J. Biol}, title = {RXRA introne polymorphism and ABO blood groups in chronic heart failure}, volume = {6}, year = {2010} }
TY - JOUR ID - 900508 AU - Pávková Goldbergová, Monika - Špinarová, Lenka - Špinar, Jindřich - Vítovec, Jiří - Pařenica, Jiří - Poloczek, Martin - Vašků, Anna PY - 2010 TI - RXRA introne polymorphism and ABO blood groups in chronic heart failure JF - Cent. Eur. J. Biol VL - 6 IS - 5 SN - 1895104X KW - gene KW - polymorphism KW - rxr KW - blood group N2 - Retinoic X receptor alpha (RXRA), a member of nuclear receptor superfamily, plays a key role in development, metabolism, glucose homeostasis, and intestinal cholesterol balance. The aim of this study was to examine an association of RXR alpha introne 5 A(39526)AA polymorphism and ABO blood groups with chronic heart failure (CHF) in the Czech population. A total of 238 patients with chronic heart failure and a control group of 246 subjects were included in the study. The RXR alpha gene polymorphism and ABO blood groups were detected by PCR and RFLP methods. Significant differences in distributions of RXRA A(39526)AA alleles and genotypes between CHF patients and controls were observed (Pg=0.03, Pa=0.02). The RXRA gene polymorphism differences of within blood group A between CHF patients and controls were highly significant in genotype distributions (Pg=0.002) and in allele frequency comparisons (Pa=0.0001). The prevalence of AA allele in CHF patients with A blood group was four-fold lower than in controls with the same blood group (OR=0.24; Pcorr=0.0001). A highly significant association of RXRA introne single-nucleotide insertion polymorphism and A blood group in chronic heart failure was observed. Our results suggest close linkage between RXRA A(39526)AA polymorphism and ABO blood groups. ER -
PÁVKOVÁ GOLDBERGOVÁ, Monika, Lenka ŠPINAROVÁ, Jindřich ŠPINAR, Jiří VÍTOVEC, Jiří PAŘENICA, Martin POLOCZEK a Anna VAŠKŮ. RXRA introne polymorphism and ABO blood groups in chronic heart failure. \textit{Cent. Eur. J. Biol}. 2010, roč.~6, č.~5, 8 s. ISSN~1895-104X.
|