| SCHULTE, Gunnar, Alexandra SCHAMBONY a Vitezslav BRYJA. b-arrestins: scaffolds and signalling elements essential for WNT/Frizzled signalling pathways? British Journal of Pharmacology. 2010, roč. 159, č. 5, s. 1051-8, 8 s. ISSN 1476-5381. |
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@article{900948,
author = {Schulte, Gunnar and Schambony, Alexandra and Bryja, Vitezslav},
article_number = {5},
keywords = {Dishevelled; RYK; ROR; b-catenin; canonical signalling; non-canonical signalling; endocytosis; desensitization; internalization; casein kinase},
language = {eng},
issn = {1476-5381},
journal = {British Journal of Pharmacology},
title = {b-arrestins: scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?},
volume = {159},
year = {2010}
}
TY - JOUR
ID - 900948
AU - Schulte, Gunnar - Schambony, Alexandra - Bryja, Vitezslav
PY - 2010
TI - b-arrestins: scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?
JF - British Journal of Pharmacology
VL - 159
IS - 5
SP - 1051-8
EP - 1051-8
SN - 14765381
KW - Dishevelled
KW - RYK
KW - ROR
KW - b-catenin
KW - canonical signalling
KW - non-canonical signalling
KW - endocytosis
KW - desensitization
KW - internalization
KW - casein kinase
N2 - Arrestins were originally identified as negative regulators of G protein-coupled receptor signaling. Recently, their diverse functions in intracellular signaling pathways as scaffold and signaling intermediate emerged providing mechanisms for achieving signal specificity and to attack for pharmacological intervention. Here, we summarize the importance of beta-arrestin function for WNT/Frizzled (FZD) signaling. WNTs are secreted lipoglycoproteins acting through the seven transmembrane spanning receptors of the FZD family. During the last years it became evident that beta-arrestins are required for cellular communication by means of WNTs and FZDs both in cellular systems as well as in vivo. Although the overall importance of arrestin for WNT/FZD signaling remains still obscure, interaction with the central phosphoprotein disheveled and the endocytic machinery implicate beta-arrestin as a determinator of WNT signaling specificity, mediator of WNT/FZD desensitization and regulator of signaling compartmentation.
ER -
SCHULTE, Gunnar, Alexandra SCHAMBONY a Vitezslav BRYJA. b-arrestins: scaffolds and signalling elements essential for WNT/Frizzled signalling pathways? \textit{British Journal of Pharmacology}. 2010, roč.~159, č.~5, s.~1051-8, 8 s. ISSN~1476-5381.
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