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@article{901090, author = {Kutschy, Peter and Sýkora, Andrej and Čurillová, Zuzana and Repovská, Mária and Pilátová, Martina and Mojžiš, Ján and Mezencev, Roman and Pazdera, Pavel and Hromjáková, Tatiana}, article_location = {Prague}, article_number = {8}, keywords = {Heterocycles; Indoles; Natural products; Phytoalexins; Glyoxylindoles;}, language = {eng}, issn = {0010-0765}, journal = {Collection of Czechoslovak Chemical Communications}, title = {GLYOXYL ANALOGS OF INDOLE PHYTOALEXINS: SYNTHESIS AND ANTICANCER ACTIVITY}, volume = {75}, year = {2010} }
TY - JOUR ID - 901090 AU - Kutschy, Peter - Sýkora, Andrej - Čurillová, Zuzana - Repovská, Mária - Pilátová, Martina - Mojžiš, Ján - Mezencev, Roman - Pazdera, Pavel - Hromjáková, Tatiana PY - 2010 TI - GLYOXYL ANALOGS OF INDOLE PHYTOALEXINS: SYNTHESIS AND ANTICANCER ACTIVITY JF - Collection of Czechoslovak Chemical Communications VL - 75 IS - 8 SP - 887–903 EP - 887–903 PB - Inst Org Chem Biochem Czech Acad Sci SN - 00100765 KW - Heterocycles KW - Indoles KW - Natural products KW - Phytoalexins KW - Glyoxylindoles; N2 - Glyoxyl analogs of indole phytoalexins brassinin, 1-methoxybrassinin, brassitin, 1-methoxybrassitin and 1-methoxybrassenin B were prepared, using (1H-indol-3-yl)-, (1-methoxyindol- 3-yl)- and [1-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl)indol-3-yl]glyoxyl chlorides as starting compounds. Synthesized products were examined for their antiproliferative activity against human cancer cell lines Jurkat (T-cell acute lymphoblastic leukemia), MCF-7 (breast adenocarcinoma, estrogen receptor-positive), MDA-MB-231 (breast adenocarcinoma, estrogen receptor-negative), HeLa (cervical adenocarcinoma), CCRF-CEM cell line (T-cell acute lymphoblastic leukemia) and A-549 cell line (lung adenocarcinoma), and their activity compared with natural phytoalexins and corresponding (1H-indol-3-yl)acetic acid derivatives. The highest potency with IC50 3.3-66.1 mímol l-1 was found for glyoxyl analogs of 1-methoxybrassenin B. ER -
KUTSCHY, Peter, Andrej SÝKORA, Zuzana ČURILLOVÁ, Mária REPOVSKÁ, Martina PILÁTOVÁ, Ján MOJŽIŠ, Roman MEZENCEV, Pavel PAZDERA a Tatiana HROMJÁKOVÁ. GLYOXYL ANALOGS OF INDOLE PHYTOALEXINS: SYNTHESIS AND ANTICANCER ACTIVITY. \textit{Collection of Czechoslovak Chemical Communications}. Prague: Inst Org Chem Biochem Czech Acad Sci, 2010, roč.~75, č.~8, s.~887–903, 12 s. ISSN~0010-0765.
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