KUTSCHY, Peter, Andrej SÝKORA, Zuzana ČURILLOVÁ, Mária REPOVSKÁ, Martina PILÁTOVÁ, Ján MOJŽIŠ, Roman MEZENCEV, Pavel PAZDERA a Tatiana HROMJÁKOVÁ. GLYOXYL ANALOGS OF INDOLE PHYTOALEXINS: SYNTHESIS AND ANTICANCER ACTIVITY. Collection of Czechoslovak Chemical Communications. Prague: Inst Org Chem Biochem Czech Acad Sci, 2010, roč. 75, č. 8, s. 887–903, 12 s. ISSN 0010-0765.
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Základní údaje
Originální název GLYOXYL ANALOGS OF INDOLE PHYTOALEXINS: SYNTHESIS AND ANTICANCER ACTIVITY
Název česky GLYOXYL ANALOGS OF INDOLE PHYTOALEXINS: SYNTHESIS AND ANTICANCER ACTIVITY
Autoři KUTSCHY, Peter (703 Slovensko), Andrej SÝKORA (703 Slovensko), Zuzana ČURILLOVÁ (703 Slovensko), Mária REPOVSKÁ (703 Slovensko), Martina PILÁTOVÁ (703 Slovensko), Ján MOJŽIŠ (703 Slovensko), Roman MEZENCEV (703 Slovensko), Pavel PAZDERA (203 Česká republika, garant, domácí) a Tatiana HROMJÁKOVÁ (703 Slovensko).
Vydání Collection of Czechoslovak Chemical Communications, Prague, Inst Org Chem Biochem Czech Acad Sci, 2010, 0010-0765.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 10401 Organic chemistry
Stát vydavatele Česká republika
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 0.853
Kód RIV RIV/00216224:14310/10:00044943
Organizační jednotka Přírodovědecká fakulta
UT WoS 000281958400008
Klíčová slova česky Heterocycles; Indoles; Natural products; Phytoalexins; Glyoxylindoles;
Klíčová slova anglicky Heterocycles; Indoles; Natural products; Phytoalexins; Glyoxylindoles;
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnil: doc. RNDr. Pavel Pazdera, CSc., učo 2276. Změněno: 21. 4. 2011 10:24.
Anotace
Glyoxyl analogs of indole phytoalexins brassinin, 1-methoxybrassinin, brassitin, 1-methoxybrassitin and 1-methoxybrassenin B were prepared, using (1H-indol-3-yl)-, (1-methoxyindol- 3-yl)- and [1-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl)indol-3-yl]glyoxyl chlorides as starting compounds. Synthesized products were examined for their antiproliferative activity against human cancer cell lines Jurkat (T-cell acute lymphoblastic leukemia), MCF-7 (breast adenocarcinoma, estrogen receptor-positive), MDA-MB-231 (breast adenocarcinoma, estrogen receptor-negative), HeLa (cervical adenocarcinoma), CCRF-CEM cell line (T-cell acute lymphoblastic leukemia) and A-549 cell line (lung adenocarcinoma), and their activity compared with natural phytoalexins and corresponding (1H-indol-3-yl)acetic acid derivatives. The highest potency with IC50 3.3-66.1 mímol l-1 was found for glyoxyl analogs of 1-methoxybrassenin B.
Anotace česky
Glyoxyl analogs of indole phytoalexins brassinin, 1-methoxybrassinin, brassitin, 1-methoxybrassitin and 1-methoxybrassenin B were prepared, using (1H-indol-3-yl)-, (1-methoxyindol- 3-yl)- and [1-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl)indol-3-yl]glyoxyl chlorides as starting compounds. Synthesized products were examined for their antiproliferative activity against human cancer cell lines Jurkat (T-cell acute lymphoblastic leukemia), MCF-7 (breast adenocarcinoma, estrogen receptor-positive), MDA-MB-231 (breast adenocarcinoma, estrogen receptor-negative), HeLa (cervical adenocarcinoma), CCRF-CEM cell line (T-cell acute lymphoblastic leukemia) and A-549 cell line (lung adenocarcinoma), and their activity compared with natural phytoalexins and corresponding (1H-indol-3-yl)acetic acid derivatives. The highest potency with IC50 3.3-66.1 mímol l-1 was found for glyoxyl analogs of 1-methoxybrassenin B.
VytisknoutZobrazeno: 14. 5. 2024 14:45