| KUBICEK, Karel, S. Kaspar GRIMM, Julien ORTS, Florenz SASSE a Teresa CARLOMAGNO. The Tubulin-Bound Structure of the Antimitotic Drug Tubulysin. Angewandte Chemie International Edition. Weinheim, Spolková republika Německo: Wiley-VCH Verlag GmbH & Co., roč. 49, č. 28, s. 4809-4812. ISSN 1433-7851. 2010. |
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@article{901496,
author = {Kubicek, Karel and Grimm, S. Kaspar and Orts, Julien and Sasse, Florenz and Carlomagno, Teresa},
article_location = {Weinheim, Spolková republika Německo},
article_number = {28},
keywords = {conformation analysis;cytotoxicity;microtubules;NMR spectroscopy;tubulysin},
language = {eng},
issn = {1433-7851},
journal = {Angewandte Chemie International Edition},
title = {The Tubulin-Bound Structure of the Antimitotic Drug Tubulysin},
url = {http://onlinelibrary.wiley.com/doi/10.1002/anie.200906828/abstract},
volume = {49},
year = {2010}
}
TY - JOUR
ID - 901496
AU - Kubicek, Karel - Grimm, S. Kaspar - Orts, Julien - Sasse, Florenz - Carlomagno, Teresa
PY - 2010
TI - The Tubulin-Bound Structure of the Antimitotic Drug Tubulysin
JF - Angewandte Chemie International Edition
VL - 49
IS - 28
SP - 4809-4812
EP - 4809-4812
PB - Wiley-VCH Verlag GmbH & Co.
SN - 14337851
KW - conformation analysis;cytotoxicity;microtubules;NMR spectroscopy;tubulysin
UR - http://onlinelibrary.wiley.com/doi/10.1002/anie.200906828/abstract
N2 - Bound to be active: The solution structure of tubulin-bound tubulysin A is determined from transferred NOE data (see picture; blue N, red O, yellow S, green C), and this bioactive conformation is compared to the unbound conformation. The binding site on tubulin is examined on the basis of the interligand NOEs observed between epothilone A and tubulysin A in the presence of tubulin.
ER -
KUBICEK, Karel, S. Kaspar GRIMM, Julien ORTS, Florenz SASSE a Teresa CARLOMAGNO. The Tubulin-Bound Structure of the Antimitotic Drug Tubulysin. \textit{Angewandte Chemie International Edition}. Weinheim, Spolková republika Německo: Wiley-VCH Verlag GmbH \&{} Co., roč.~49, č.~28, s.~4809-4812. ISSN~1433-7851. 2010.
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