The Effects of Lidocaine on Bupivacaine-Induced Cardiotoxicity
in the Isolated Rat Heart

J 2010

The Effects of Lidocaine on Bupivacaine-Induced Cardiotoxicity in the Isolated Rat Heart

KŘIKAVA, Ivo, Jiří JARKOVSKÝ, Petr ŠTOURAČ, Marie NOVÁKOVÁ, Pavel ŠEVČÍK et. al.

Základní údaje

Originální název

The Effects of Lidocaine on Bupivacaine-Induced Cardiotoxicity in the Isolated Rat Heart

Autoři

KŘIKAVA, Ivo (203 Česká republika, garant), Jiří JARKOVSKÝ (203 Česká republika, domácí), Petr ŠTOURAČ (203 Česká republika), Marie NOVÁKOVÁ (203 Česká republika, domácí) a Pavel ŠEVČÍK (203 Česká republika, domácí)

Vydání

Physiological Research, Praha, Institute of Physiology,Academy of Sciences of the Czech Republic, 2010, 0862-8408

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.646

Kód RIV

RIV/00216224:14110/10:00045035

Organizační jednotka

Lékařská fakulta

UT WoS

000279049100010

Klíčová slova česky

Bupivakain;Lidokain;Izolované srdce potkana;Kardiotoxicita;Trvání QRS

Klíčová slova anglicky

Bupivacaine;Lidocaine;Isolated rat heart;Cardiotoxicity;QRS duration

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 9. 2012 14:39, prof. MUDr. Petr Štourač, Ph.D., MBA, FESAIC

Anotace

V originále

Bupivacaine is a widely used long-acting local anaesthetic. The aim of this study was to compare the cardiotoxicity of large doses of bupivacaine and mixture of bupivacaine with lidocaine in the isolated rat heart and to estimate whether or not the addition of lidocaine in clinically relevant concentration increases bupivacaine-induced toxicity. Experiments were performed on 21 adult male rats divided into three groups: B (6 mu g/ml bupivacaine), BL (6 mu g/ml bupivacaine and 12 mu g/ml lidocaine) and L (12 mu g/ml lidocaine). The isolated hearts were perfused according to Langendorff with Krebs-Henseleit solution at constant pressure and the heart rate, PQ and QRS intervals were measured. The present study shows that the mixture of tested local anaesthetics - bupivacaine and lidocaine - impairs the intraventricular conduction parameters (QRS interval prolongation) to a lesser extent than bupivacaine itself, and that this effect is marked mainly at the beginning of perfusion.

Návaznosti

GA102/07/1473, projekt VaV

Název: Optické metody registrace elektrických potenciálů a koncentrace vápníku v srdci s laserovou stabilizací

Investor: Grantová agentura ČR, Optické metody registrace elektrických potenciálů a koncentrace vápníku v srdci s laserovou stabilizací

MSM0021622402, záměr

Název: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Časná diagnostika a léčba kardiovaskulárních chorob

Citovat

KŘIKAVA, Ivo, Jiří JARKOVSKÝ, Petr ŠTOURAČ, Marie NOVÁKOVÁ a Pavel ŠEVČÍK. The Effects of Lidocaine on Bupivacaine-Induced Cardiotoxicity in the Isolated Rat Heart. Physiological Research. Praha: Institute of Physiology,Academy of Sciences of the Czech Republic, 2010, roč. 59, Suppl. 1, s. S65-S69, 5 s. ISSN 0862-8408.

@article{902214,
   author = {Křikava, Ivo and Jarkovský, Jiří and Štourač, Petr and Nováková, Marie and Ševčík, Pavel},
   article_location = {Praha},
   article_number = {Suppl. 1},
   keywords = {Bupivacaine;Lidocaine;Isolated rat heart;Cardiotoxicity;QRS duration},
   language = {eng},
   issn = {0862-8408},
   journal = {Physiological Research},
   title = {The Effects of Lidocaine on Bupivacaine-Induced Cardiotoxicity in the Isolated Rat Heart},
   url = {http://www.biomed.cas.cz/physiolres/2010/S1_10.htm},
   volume = {59},
   year = {2010}
}

TY  - JOUR
ID  - 902214
AU  - Křikava, Ivo - Jarkovský, Jiří - Štourač, Petr - Nováková, Marie - Ševčík, Pavel
PY  - 2010
TI  - The Effects of Lidocaine on Bupivacaine-Induced Cardiotoxicity in the Isolated Rat Heart
JF  - Physiological Research
VL  - 59
IS  - Suppl. 1
SP  - S65-S69
EP  - S65-S69
PB  - Institute of Physiology,Academy of Sciences of the Czech Republic
SN  - 08628408
KW  - Bupivacaine;Lidocaine;Isolated rat heart;Cardiotoxicity;QRS duration
UR  - http://www.biomed.cas.cz/physiolres/2010/S1_10.htm
N2  - Bupivacaine is a widely used long-acting local anaesthetic. The aim of this study was to compare the cardiotoxicity of large doses of bupivacaine and mixture of bupivacaine with lidocaine in the isolated rat heart and to estimate whether or not the addition of lidocaine in clinically relevant concentration increases bupivacaine-induced toxicity. Experiments were performed on 21 adult male rats divided into three groups: B (6 mu g/ml bupivacaine), BL (6 mu g/ml bupivacaine and 12 mu g/ml lidocaine) and L (12 mu g/ml lidocaine). The isolated hearts were perfused according to Langendorff with Krebs-Henseleit solution at constant pressure and the heart rate, PQ and QRS intervals were measured. The present study shows that the mixture of tested local anaesthetics - bupivacaine and lidocaine - impairs the intraventricular conduction parameters (QRS interval prolongation) to a lesser extent than bupivacaine itself, and that this effect is marked mainly at the beginning of perfusion.
ER  -

KŘIKAVA, Ivo, Jiří JARKOVSKÝ, Petr ŠTOURAČ, Marie NOVÁKOVÁ a Pavel ŠEVČÍK. The Effects of Lidocaine on Bupivacaine-Induced Cardiotoxicity in the Isolated Rat Heart. \textit{Physiological Research}. Praha: Institute of Physiology,Academy of Sciences of the Czech Republic, 2010, roč.~59, Suppl. 1, s.~S65-S69, 5 s. ISSN~0862-8408.

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