BOUCHAL, Pavel, Monika MUDROCHOVÁ, Eva BUDINSKÁ, Zbyněk BORTLÍČEK, Iva STRUHÁROVÁ, Lenka HERNYCHOVÁ, Theodoros ROUMELIOTIS, Spiros D. GARBIS, Roman HRSTKA, Petr MÜLLER, Rudolf NENUTIL a Bořivoj VOJTĚŠEK. Biomarkers of lymph node metastasis in low-grade breast cancer: An integrated, proteomics-based approach. In XXII. Biochemický zjazd: The Book of Abstracts. 2010. ISBN 978-80-88866-83-1. |
Další formáty:
BibTeX
LaTeX
RIS
@misc{902356, author = {Bouchal, Pavel and Mudrochová, Monika and Budinská, Eva and Bortlíček, Zbyněk and Struhárová, Iva and Hernychová, Lenka and Roumeliotis, Theodoros and Garbis, Spiros D. and Hrstka, Roman and Müller, Petr and Nenutil, Rudolf and Vojtěšek, Bořivoj}, booktitle = {XXII. Biochemický zjazd: The Book of Abstracts}, keywords = {breast cancer; lymph node metastasis; proteomics}, language = {eng}, isbn = {978-80-88866-83-1}, title = {Biomarkers of lymph node metastasis in low-grade breast cancer: An integrated, proteomics-based approach}, year = {2010} }
TY - SLIDE ID - 902356 AU - Bouchal, Pavel - Mudrochová, Monika - Budinská, Eva - Bortlíček, Zbyněk - Struhárová, Iva - Hernychová, Lenka - Roumeliotis, Theodoros - Garbis, Spiros D. - Hrstka, Roman - Müller, Petr - Nenutil, Rudolf - Vojtěšek, Bořivoj PY - 2010 TI - Biomarkers of lymph node metastasis in low-grade breast cancer: An integrated, proteomics-based approach SN - 9788088866831 KW - breast cancer KW - lymph node metastasis KW - proteomics N2 - Our effort has been focused on biomarker discovery in the set of 96 breast cancer tumors divided into groups according to grade and presence or absence of lymph node metastases. Three proteomics approaches were involved in complex protein analysis of tissue lysates: (i) SELDI-TOF MS enabled us to quantify 130 intact protein peaks. One protein peak correlating with lymph node metastases was detected and identified. (ii) Selected set of tumors was analyzed using iTRAQ-2DLC-MS/MS approach. This approach provides a simultaneous identification and quantitation of more than 600 proteins. (iii) Set of selected tumor lysates was analyzed also using 2-D SDS-PAGE. The expression variability of 26 selected gene products was validated using qRT-PCR. Generally, our results indicate the differential expression of (i) cytoskeletal proteins, (ii) AGR protein family members and (iii) proteins involved in heme biosynthesis. ER -
BOUCHAL, Pavel, Monika MUDROCHOVÁ, Eva BUDINSKÁ, Zbyněk BORTLÍČEK, Iva STRUHÁROVÁ, Lenka HERNYCHOVÁ, Theodoros ROUMELIOTIS, Spiros D. GARBIS, Roman HRSTKA, Petr MÜLLER, Rudolf NENUTIL a Bořivoj VOJTĚŠEK. Biomarkers of lymph node metastasis in low-grade breast cancer: An integrated, proteomics-based approach. In \textit{XXII. Biochemický zjazd: The Book of Abstracts}. 2010. ISBN~978-80-88866-83-1.
|