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@article{903217,
author = {Ráčil, Zdeněk and Kocmanová, Iva and Lengerová, Martina and Weinbergerová, Barbora and Burešová, Lucie and Tošková, Martina and Winterová, Jana and Timilsina, Shira and Rodriguez, Isa and Mayer, Jiří},
article_location = {Great Britain},
article_number = {9},
doi = {http://dx.doi.org/10.1099/jmm.0.019299-0},
keywords = {invasive fungal disease; glucan; false positive results},
language = {eng},
issn = {0022-2615},
journal = {Journal of Medical Microbiology},
title = {Difficulties in using 1,3-ß-D glucan as the screening test for the early diagnosis of invasive fungal diseases in patients with hematological malignancies - high frequency of false positive results and their analysis.},
volume = {59},
year = {2010}
}
TY - JOUR
ID - 903217
AU - Ráčil, Zdeněk - Kocmanová, Iva - Lengerová, Martina - Weinbergerová, Barbora - Burešová, Lucie - Tošková, Martina - Winterová, Jana - Timilsina, Shira - Rodriguez, Isa - Mayer, Jiří
PY - 2010
TI - Difficulties in using 1,3-ß-D glucan as the screening test for the early diagnosis of invasive fungal diseases in patients with hematological malignancies - high frequency of false positive results and their analysis.
JF - Journal of Medical Microbiology
VL - 59
IS - 9
SP - 1016-1022
EP - 1016-1022
PB - 2010 SGM
SN - 00222615
KW - invasive fungal disease
KW - glucan
KW - false positive results
N2 - We have evaluated the contribution of 1,3-ß-D-glucan (BG) assay for screening of invasive fungal diseases (IFI) in patients with hematological malignancies. Serum samples from patients at risk of IFI were collected twice a week and retrospectively tested using the BG assay. BG screening was performed on 1143 samples from 91 patients during 104 anticancer treatment cycles. Proven and probable cases of IFI occurred in 9 (8.7%) treatment cycles. Depending on the criterion of positivity used (1> 60 or 1> 80 pg/ml and 2> 60 or 2> 80 pg/ml) the sensitivity was 89%, 89%, 67% and 44%. Although the test was marked as positive in 82%, 68%, 54% and 45% of all the treatment cycles, in the majority of cases, these positivities were probably false. The major limit of the BG test was extremely low PPV (10% to 12%). We have analyzed mucositis, candida colonization, bacteremia, using antimicrobials, erythrocyte and thrombocyte filtered blood products, collecting tubes or sampling via venous catheters. Even though no factor is a major source of BG, it could at least partially influence BG assay performance. Thus, the BG detection has a limited usefulness as a screening method for invasive fungal infections in patients with hematological malignancies.
ER -
RÁČIL, Zdeněk, Iva KOCMANOVÁ, Martina LENGEROVÁ, Barbora WEINBERGEROVÁ, Lucie BUREŠOVÁ, Martina TOŠKOVÁ, Jana WINTEROVÁ, Shira TIMILSINA, Isa RODRIGUEZ a Jiří MAYER. Difficulties in using 1,3-ß-D glucan as the screening test for the early diagnosis of invasive fungal diseases in patients with hematological malignancies - high frequency of false positive results and their analysis. \textit{Journal of Medical Microbiology}. Great Britain: 2010 SGM, 2010, roč.~59, č.~9, s.~1016-1022. ISSN~0022-2615. Dostupné z: https://dx.doi.org/10.1099/jmm.0.019299-0.
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