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@article{905699, author = {Dubový, Petr and Klusáková, Ilona and Hradilová Svíženská, Ivana and Brázda, Václav}, article_location = {United Kingdom}, article_number = {1}, keywords = {neuroinflammation; cytokine; unilateral nerve injury; contralateral}, language = {eng}, issn = {1740-925X}, journal = {Neuron Glia Biology}, title = {Satellite glial cells express IL-6 and corresponding signal-transducing receptors in the dorsal root ganglia of rat neuropathic pain model}, volume = {6/2010}, year = {2010} }
TY - JOUR ID - 905699 AU - Dubový, Petr - Klusáková, Ilona - Hradilová Svíženská, Ivana - Brázda, Václav PY - 2010 TI - Satellite glial cells express IL-6 and corresponding signal-transducing receptors in the dorsal root ganglia of rat neuropathic pain model JF - Neuron Glia Biology VL - 6/2010 IS - 1 SP - 73-83 EP - 73-83 PB - Cambridge University Press SN - 1740925X KW - neuroinflammation KW - cytokine KW - unilateral nerve injury KW - contralateral N2 - There is a growing body of evidence that cytokines contribute to both induction and maintenance of neuropathic pain derived from changes in dorsal root ganglia (DRG). We used immunofluorescence and in situ hybridization methods to provide evidence that chronic constriction injury (CCI) of the sciatic nerve induces synthesis of interleukin-6 (IL-6) in SGC, elevation of IL-6 receptor (IL-6R) and activation of signal transducer and activator of transcription 3 (STAT3) signalling. Unilateral CCI of the rat sciatic nerve induced mechanoallodynia and thermal hyperalgesia in ipsilateral hind paws, but contralateral paws exhibited only temporal changes of sensitivity. We demonstrated that IL-6 mRNA and protein, which were expressed at very low levels in naive DRG, were bilaterally increased not only in L4-L5 DRG neurons but also in SGC activated by unilateral CCI. Besides IL-6, substantial increase of IL-6R and pSTAT3 expression occurred in SGC following CCI, however, IL-6R associated protein, gp130 levels did not change. ER -
DUBOVÝ, Petr, Ilona KLUSÁKOVÁ, Ivana HRADILOVÁ SVÍŽENSKÁ a Václav BRÁZDA. Satellite glial cells express IL-6 and corresponding signal-transducing receptors in the dorsal root ganglia of rat neuropathic pain model. \textit{Neuron Glia Biology}. United Kingdom: Cambridge University Press, 2010, roč.~6/2010, č.~1, s.~73-83. ISSN~1740-925X.
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