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@article{905699,
author = {Dubový, Petr and Klusáková, Ilona and Hradilová Svíženská, Ivana and Brázda, Václav},
article_location = {United Kingdom},
article_number = {1},
keywords = {neuroinflammation; cytokine; unilateral nerve injury; contralateral},
language = {eng},
issn = {1740-925X},
journal = {Neuron Glia Biology},
title = {Satellite glial cells express IL-6 and corresponding signal-transducing receptors in the dorsal root ganglia of rat neuropathic pain model},
volume = {6/2010},
year = {2010}
}
TY - JOUR
ID - 905699
AU - Dubový, Petr - Klusáková, Ilona - Hradilová Svíženská, Ivana - Brázda, Václav
PY - 2010
TI - Satellite glial cells express IL-6 and corresponding signal-transducing receptors in the dorsal root ganglia of rat neuropathic pain model
JF - Neuron Glia Biology
VL - 6/2010
IS - 1
SP - 73-83
EP - 73-83
PB - Cambridge University Press
SN - 1740925X
KW - neuroinflammation
KW - cytokine
KW - unilateral nerve injury
KW - contralateral
N2 - There is a growing body of evidence that cytokines contribute to both induction and maintenance of neuropathic pain derived from changes in dorsal root ganglia (DRG). We used immunofluorescence and in situ hybridization methods to provide evidence that chronic constriction injury (CCI) of the sciatic nerve induces synthesis of interleukin-6 (IL-6) in SGC, elevation of IL-6 receptor (IL-6R) and activation of signal transducer and activator of transcription 3 (STAT3) signalling. Unilateral CCI of the rat sciatic nerve induced mechanoallodynia and thermal hyperalgesia in ipsilateral hind paws, but contralateral paws exhibited only temporal changes of sensitivity. We demonstrated that IL-6 mRNA and protein, which were expressed at very low levels in naive DRG, were bilaterally increased not only in L4-L5 DRG neurons but also in SGC activated by unilateral CCI. Besides IL-6, substantial increase of IL-6R and pSTAT3 expression occurred in SGC following CCI, however, IL-6R associated protein, gp130 levels did not change.
ER -
DUBOVÝ, Petr, Ilona KLUSÁKOVÁ, Ivana HRADILOVÁ SVÍŽENSKÁ a Václav BRÁZDA. Satellite glial cells express IL-6 and corresponding signal-transducing receptors in the dorsal root ganglia of rat neuropathic pain model. \textit{Neuron Glia Biology}. United Kingdom: Cambridge University Press, 2010, roč.~6/2010, č.~1, s.~73-83. ISSN~1740-925X.
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