TESAŘOVÁ, Lenka, Irena KRONTORÁD KOUTNÁ, Zdeněk KOŘÍSTEK a Martin KLABUSAY. Multiple myeloma patients at peripheral blood stem cell harvest: restricted usage of TCR beta variable families. Clinical Immunology. Elsevier, 2011, roč. 138, č. 1, s. 67-76. ISSN 1521-6616. Dostupné z: https://dx.doi.org/10.1016/j.clim.2010.09.007. |
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@article{907729, author = {Tesařová, Lenka and Krontorád Koutná, Irena and Kořístek, Zdeněk and Klabusay, Martin}, article_number = {1}, doi = {http://dx.doi.org/10.1016/j.clim.2010.09.007}, keywords = {T-cell receptor; Beta variable families; Multiple myeloma; Reverse transcription polymerase chain reaction; Capillary electrophoresis}, language = {eng}, issn = {1521-6616}, journal = {Clinical Immunology}, title = {Multiple myeloma patients at peripheral blood stem cell harvest: restricted usage of TCR beta variable families}, volume = {138}, year = {2011} }
TY - JOUR ID - 907729 AU - Tesařová, Lenka - Krontorád Koutná, Irena - Kořístek, Zdeněk - Klabusay, Martin PY - 2011 TI - Multiple myeloma patients at peripheral blood stem cell harvest: restricted usage of TCR beta variable families JF - Clinical Immunology VL - 138 IS - 1 SP - 67-76 EP - 67-76 PB - Elsevier SN - 15216616 KW - T-cell receptor KW - Beta variable families KW - Multiple myeloma KW - Reverse transcription polymerase chain reaction KW - Capillary electrophoresis N2 - The immune systems of multiple myeloma patients are suppressed by the disease itself, and this immunosuppression is further enhanced by standard therapies. The aim of our study was to evaluate the effects of initial chemotherapy and a peripheral blood mobilisation regimen on T-cell population diversity. Reverse transcription polymerase chain reaction (RT-PCR) with a new set of primers, in combination with capillary electrophoresis, was established. The methodology was used to analyse the relative expression of 27 T-cell receptor beta variable gene families (BV families) in multiple myeloma patients undergoing peripheral blood stem cell harvest. We found that the overall BV family usage in these patients was restricted; the relative expression of 10 BV families was significantly depressed in patients compared to healthy donors. These findings demonstrate that the preparative regimen for autologous stem cell transplantation affects the T-cell population in terms of the restriction of its T-cell receptor diversity. ER -
TESAŘOVÁ, Lenka, Irena KRONTORÁD KOUTNÁ, Zdeněk KOŘÍSTEK a Martin KLABUSAY. Multiple myeloma patients at peripheral blood stem cell harvest: restricted usage of TCR beta variable families. \textit{Clinical Immunology}. Elsevier, 2011, roč.~138, č.~1, s.~67-76. ISSN~1521-6616. Dostupné z: https://dx.doi.org/10.1016/j.clim.2010.09.007.
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