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@inproceedings{907864,
author = {Ručka, Zdeněk and Tesařová, Lenka and Potěšilová, Michaela and Stejskal, Stanislav and Krontorád Koutná, Irena and Vaňhara, Petr and Doležel, Jan},
address = {Brno, Česká republika},
booktitle = {Advances in Molecular and Cancer Biology, 2010},
keywords = {Lung surfactant; Insulin; Dexamethasone},
language = {eng},
location = {Brno, Česká republika},
isbn = {978-80-210-5312-0},
pages = {36-38},
publisher = {muni PRESS},
title = {Dexamethasone and Insulin Affecting SFTPA1 and SFTPA2 mRNA Levels},
year = {2010}
}
TY - JOUR
ID - 907864
AU - Ručka, Zdeněk - Tesařová, Lenka - Potěšilová, Michaela - Stejskal, Stanislav - Krontorád Koutná, Irena - Vaňhara, Petr - Doležel, Jan
PY - 2010
TI - Dexamethasone and Insulin Affecting SFTPA1 and SFTPA2 mRNA Levels
PB - muni PRESS
CY - Brno, Česká republika
SN - 9788021053120
KW - Lung surfactant
KW - Insulin
KW - Dexamethasone
N2 - Lung surfactants primary function is to lower surface tension and therefore it protects alveoli from collapsing. It consists of phospholipids and four proteins. These proteins stabilize the surfactant layer (SFTPB and SFTPC) and modulate immunological response to various pathogens (SFTPA, SFTPD), which is the secondary role of lung surfactant. Low levels of surfactant proteins lead to severe diseases. Dexamethasone and insulin were applied on H441 cell line. This cell line resembles Clara cells and therefore serves as a model of lung surfactant producing cells. SFTPA1 (and its analog SFTPA2) were not affected by insulin (2500 ng/mL), but dexamethasone treatment (10-7 M) for 48 hours resulted in 50% decrease in their mRNA production. Surprisingly, combination of dexamethasone and insulin resulted in 90% decrease.
ER -
RUČKA, Zdeněk, Lenka TESAŘOVÁ, Michaela POTĚŠILOVÁ, Stanislav STEJSKAL, Irena KRONTORÁD KOUTNÁ, Petr VAŇHARA a Jan DOLEŽEL. Dexamethasone and Insulin Affecting SFTPA1 and SFTPA2 mRNA Levels. In \textit{Advances in Molecular and Cancer Biology, 2010}. Brno, Česká republika: muni PRESS, 2010, s.~36-38. ISBN~978-80-210-5312-0.
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