Haloperidol increases expression of the inositol
1,4,5-trisphosphate receptors in rat cardiac atria, but not in
vnetricles

J 2010

Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles

NOVÁKOVÁ, Marie; Barbora SEDLÁKOVÁ; Marta SIROVÁ; Kateřina FIALOVÁ; Olga KRIŽANOVÁ et. al.

Základní údaje

Originální název

Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles

Autoři

NOVÁKOVÁ, Marie (203 Česká republika, garant); Barbora SEDLÁKOVÁ (703 Slovensko); Marta SIROVÁ (703 Slovensko); Kateřina FIALOVÁ (203 Česká republika) a Olga KRIŽANOVÁ (703 Slovensko)

Vydání

General Physioogy and Biophysics, Bratislava, INST OF MOLEC PHYSIOL GENETICS SLOVAK AC, 2010, 0231-5882

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Slovensko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.146

Kód RIV

RIV/00216224:14110/10:00045742

Organizační jednotka

Lékařská fakulta

UT WoS

000286693400007

Klíčová slova česky

haloperidol; sigma receptor; IP3 receptor

Klíčová slova anglicky

haloperidol; sigma receptor; IP3 receptor

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 12. 2010 13:29, MUDr. Kateřina Fialová, Ph.D.

Anotace

V originále

Numerous ligands of sigma receptors are known to prolong the QT interval and therefore to cause a variety of arrhythmias. High affinity binding sites for the prototypical sigma ligand haloperidol were found in membranes of cardiac myocytes from adult rats. Activation of sigma 1 receptor leads to a release of calcium from the endoplasmic reticulum that follows increased synthesis of inositol 1,4,5-trisphosphate (IP3). We studied the effect of long-term haloperidol treatment on the expression of sigma 1 receptors, IP3 receptors of type 1 and 2 in the individual parts of the rat heart, in isolated rat cardiomyocytes and in PC12 cells. We have found that prolonged treatment with haloperidol significantly increased mRNA levels of sigma 1 receptors in both atria and ventricles. Sigma 1 receptor s mRNA was increased also in isolated cardiomyocytes. Haloperidol treatment affects the expression of IP3 receptors of type 1 and 2 in cardiac atria, but not in cardiac ventricles.

Návaznosti

GA102/07/1473, projekt VaV

Název: Optické metody registrace elektrických potenciálů a koncentrace vápníku v srdci s laserovou stabilizací

Investor: Grantová agentura ČR, Optické metody registrace elektrických potenciálů a koncentrace vápníku v srdci s laserovou stabilizací

MSM0021622402, záměr

Název: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Časná diagnostika a léčba kardiovaskulárních chorob

Citovat

NOVÁKOVÁ, Marie; Barbora SEDLÁKOVÁ; Marta SIROVÁ; Kateřina FIALOVÁ a Olga KRIŽANOVÁ. Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles. General Physioogy and Biophysics. Bratislava: INST OF MOLEC PHYSIOL GENETICS SLOVAK AC, 2010, roč. 29, č. 4, s. 381-389. ISSN 0231-5882.

@article{911684,
   author = {Nováková, Marie and Sedláková, Barbora and Sirová, Marta and Fialová, Kateřina and Križanová, Olga},
   article_location = {Bratislava},
   article_number = {4},
   keywords = {haloperidol; sigma receptor; IP3 receptor},
   language = {eng},
   issn = {0231-5882},
   journal = {General Physioogy and Biophysics},
   title = {Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles},
   volume = {29},
   year = {2010}
}

TY  - JOUR
ID  - 911684
AU  - Nováková, Marie - Sedláková, Barbora - Sirová, Marta - Fialová, Kateřina - Križanová, Olga
PY  - 2010
TI  - Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles
JF  - General Physioogy and Biophysics
VL  - 29
IS  - 4
SP  - 381-389
EP  - 381-389
PB  - INST OF MOLEC PHYSIOL GENETICS SLOVAK AC
SN  - 02315882
KW  - haloperidol
KW  - sigma receptor
KW  - IP3 receptor
N2  - Numerous ligands of sigma receptors are known to prolong the QT interval and therefore to cause a variety of arrhythmias. High affinity binding sites for the prototypical sigma ligand haloperidol were found in membranes of cardiac myocytes from adult rats. Activation of sigma 1 receptor leads to a release of calcium from the endoplasmic reticulum that follows increased synthesis of inositol 1,4,5-trisphosphate (IP3). We studied the effect of long-term haloperidol treatment on the expression of sigma 1 receptors, IP3 receptors of type 1 and 2 in the individual parts of the rat heart, in isolated rat cardiomyocytes and in PC12 cells. We have found that prolonged treatment with haloperidol significantly increased mRNA levels of sigma 1 receptors in both atria and ventricles. Sigma 1 receptor s mRNA was increased also in isolated cardiomyocytes. Haloperidol treatment affects the expression of IP3 receptors of type 1 and 2 in cardiac atria, but not in cardiac ventricles.
ER  -

NOVÁKOVÁ, Marie; Barbora SEDLÁKOVÁ; Marta SIROVÁ; Kateřina FIALOVÁ a Olga KRIŽANOVÁ. Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles. \textit{General Physioogy and Biophysics}. Bratislava: INST OF MOLEC PHYSIOL GENETICS SLOVAK AC, 2010, roč.~29, č.~4, s.~381-389. ISSN~0231-5882.

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