IDH2 mutations in patients with acute myeloid leukemia:
missense p.R140 mutations are linked to disease status

J 2010

IDH2 mutations in patients with acute myeloid leukemia: missense p.R140 mutations are linked to disease status

JEŽÍŠKOVÁ, Ivana; Filip RÁZGA; Monika BAJEROVÁ; Zdeněk RÁČIL; Jiří MAYER et al.

Základní údaje

Originální název

IDH2 mutations in patients with acute myeloid leukemia: missense p.R140 mutations are linked to disease status

Autoři

JEŽÍŠKOVÁ, Ivana; Filip RÁZGA; Monika BAJEROVÁ; Zdeněk RÁČIL; Jiří MAYER a Dana DVOŘÁKOVÁ

Vydání

Leukemia & Lymphoma, Gordon and Breach, 2010, 1042-8194

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.492

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/10:00067242

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.3109/10428194.2010.523126

UT WoS

000285004300021

Klíčová slova anglicky

acute myeloid leukemia

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 25. 4. 2014 13:05, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

In conclusion, our data demonstrate that, within the cohort of tested individuals, the IDH2 mutations are associated with AML (in contrast to healthy volunteers), suggesting a role for these mutations in disease pathogenesis. In addition, we show an association of the observed IDH2 mutations with disease status, indicating their potential for MRD monitoring. This report thus indicates that IDH2 p.R140 variants are possible markers for MRD detection. However, an extended investigation of IDH2 mutations kinetics, involving long-term followup and a larger cohort of IDH2 mutated AMLs, will be required to confirm these findings.

Citovat

JEŽÍŠKOVÁ, Ivana; Filip RÁZGA; Monika BAJEROVÁ; Zdeněk RÁČIL; Jiří MAYER a Dana DVOŘÁKOVÁ. IDH2 mutations in patients with acute myeloid leukemia: missense p.R140 mutations are linked to disease status. Leukemia & Lymphoma. Gordon and Breach, 2010, roč. 51, č. 12, s. 2285-2287. ISSN 1042-8194. Dostupné z: https://doi.org/10.3109/10428194.2010.523126.

@article{914488,
   author = {Ježíšková, Ivana and Rázga, Filip and Bajerová, Monika and Ráčil, Zdeněk and Mayer, Jiří and Dvořáková, Dana},
   article_number = {12},
   doi = {https://doi.org/10.3109/10428194.2010.523126},
   keywords = {acute myeloid leukemia},
   language = {eng},
   issn = {1042-8194},
   journal = {Leukemia & Lymphoma},
   title = {IDH2 mutations in patients with acute myeloid leukemia: missense p.R140 mutations are linked to disease status},
   volume = {51},
   year = {2010}
}

TY  - JOUR
ID  - 914488
AU  - Ježíšková, Ivana - Rázga, Filip - Bajerová, Monika - Ráčil, Zdeněk - Mayer, Jiří - Dvořáková, Dana
PY  - 2010
TI  - IDH2 mutations in patients with acute myeloid leukemia: missense p.R140 mutations are linked to disease status
JF  - Leukemia & Lymphoma
VL  - 51
IS  - 12
SP  - 2285-2287
EP  - 2285-2287
PB  - Gordon and Breach
SN  - 10428194
KW  - acute myeloid leukemia
N2  - In conclusion, our data demonstrate that, within the cohort of tested individuals, the IDH2 mutations are associated with AML (in contrast to healthy volunteers), suggesting a role for these mutations in disease pathogenesis. In addition, we show an association of the observed IDH2 mutations with disease status, indicating their potential for MRD monitoring. This report thus indicates that IDH2 p.R140 variants are possible markers for MRD detection. However, an extended investigation of IDH2 mutations kinetics, involving long-term followup and a larger cohort of IDH2 mutated AMLs, will be required to confirm these findings.
ER  -

JEŽÍŠKOVÁ, Ivana; Filip RÁZGA; Monika BAJEROVÁ; Zdeněk RÁČIL; Jiří MAYER a Dana DVOŘÁKOVÁ. IDH2 mutations in patients with acute myeloid leukemia: missense p.R140 mutations are linked to disease status. \textit{Leukemia \&{} Lymphoma}. Gordon and Breach, 2010, roč.~51, č.~12, s.~2285-2287. ISSN~1042-8194. Dostupné z: https://doi.org/10.3109/10428194.2010.523126.

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