| LUBAL, Přemysl, Jakub VANĚK, Romana ŠEVČÍKOVÁ, Miloslav POLÁŠEK, Petr HERMANN a Ivan LUKEŠ. Ln(III) complexes of Mono(Pyridine-N-oxide) Analog of DOTA as a Potential Bimodal and Luminescence Imaging Agents. In Abstract book of XIV. Symposium on Luminescence Spectrometry. Praha: Faculty of Pharmacy, Charles University Prague, 2010, 216 s. ISBN 978-80-254-6830-2. |
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@inproceedings{915874,
author = {Lubal, Přemysl and Vaněk, Jakub and Ševčíková, Romana and Polášek, Miloslav and Hermann, Petr and Lukeš, Ivan},
address = {Praha},
booktitle = {Abstract book of XIV. Symposium on Luminescence Spectrometry},
keywords = {Macrocyclic ligand; Ln(III) ions; thermodynamics; kinetics; photophysics; analytical determination},
language = {eng},
location = {Praha},
isbn = {978-80-254-6830-2},
publisher = {Faculty of Pharmacy, Charles University Prague},
title = {Ln(III) complexes of Mono(Pyridine-N-oxide) Analog of DOTA as a Potential Bimodal and Luminescence Imaging Agents},
year = {2010}
}
TY - JOUR
ID - 915874
AU - Lubal, Přemysl - Vaněk, Jakub - Ševčíková, Romana - Polášek, Miloslav - Hermann, Petr - Lukeš, Ivan
PY - 2010
TI - Ln(III) complexes of Mono(Pyridine-N-oxide) Analog of DOTA as a Potential Bimodal and Luminescence Imaging Agents
PB - Faculty of Pharmacy, Charles University Prague
CY - Praha
SN - 9788025468302
KW - Macrocyclic ligand
KW - Ln(III) ions
KW - thermodynamics
KW - kinetics
KW - photophysics
KW - analytical determination
N2 - Ln(III) complexes of H4dota and its derivatives are utilized in many areas of medicine. The molecular spectroscopy in UV/VIS region was employed to investigate chemical features of Eu(III)/Gd(III)/Tb(III) complexes of the title ligand in order to investigate their possible applications as bimodal agents. The stability constants and acid-assisted dissociation of Ln(III) complexes show high thermodynamic stability and kinetic inertness. In the study of formation (pH = 5.0-6.0, t = 25 C, I = 0.1 M KCl) was found that the reactive species is HL 2- and the rate increases with decreasing ionic radius of the metal ions and it follows a trend along the Ln(III) series. The ligand capable of complex formation due show interesting photophysical properties to presence of chromophor/fluorophor group and it enables to determine the low concentration of Eu(III)/Tb(III) ions.
ER -
LUBAL, Přemysl, Jakub VANĚK, Romana ŠEVČÍKOVÁ, Miloslav POLÁŠEK, Petr HERMANN a Ivan LUKEŠ. Ln(III) complexes of Mono(Pyridine-N-oxide) Analog of DOTA as a Potential Bimodal and Luminescence Imaging Agents. In \textit{Abstract book of XIV. Symposium on Luminescence Spectrometry}. Praha: Faculty of Pharmacy, Charles University Prague, 2010, 216 s. ISBN~978-80-254-6830-2.
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