a 2010

Mono(pyridine-N-oxide) analog of DOTA ligand as suitable sensor for Ln(III) ions

LUBAL, Přemysl, Jakub VANĚK and Petr HERMANN

Basic information

Original name

Mono(pyridine-N-oxide) analog of DOTA ligand as suitable sensor for Ln(III) ions

Authors

LUBAL, Přemysl (203 Czech Republic, guarantor, belonging to the institution), Jakub VANĚK (203 Czech Republic, belonging to the institution) and Petr HERMANN (203 Czech Republic, belonging to the institution)

Edition

Abstract book of Spring ACS meeting 2010 -document Nr. 17777, 2010

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

10406 Analytical chemistry

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14310/10:00046467

Organization unit

Faculty of Science

Keywords in English

Macrocyclic ligand; Ln(III) ions; thermodynamics; kinetics; photophysics; analytical determination
Změněno: 11/1/2011 13:40, prof. RNDr. Přemysl Lubal, Ph.D.

Abstract

V originále

Ln(III) complexes of DOTA ligand and its derivatives are utilized in many areas of medicine (e.g. complexes of metal radioisotopes as 90Y, 153Sm, 166Ho, 177Lu in nuclear medicine, Gd(III) complexes as MRI contrast agents, Eu(III)/Tb(III) complexes as luminescent probes). In this contribution, the thermodynamic and kinetic properties of Ln(III) complexes (Ln = Ce, Eu, Gd, Yb) of the mono(pyridine-N-oxide) DOTA derivative were studied by molecular absorption and emission spectroscopies (in UV/VIS region, luminescence, TRFS) in order to investigate possible analytical application of title ligand. The stability constants and acid-assisted dissociation of Ln(III) complexes show high thermodynamic stability and kinetic inertness. Ln(III) complexes show interesting photophysical properties due to presence of chromophor/fluorophor group which enables to make sensor suitable for determination of low concentration of Eu(III)/Tb(III) ions.

Links

ME09065, research and development project
Name: Výzkum nových detekčních systémů na bázi senzorových polí pro použití ve speciační analýze
Investor: Ministry of Education, Youth and Sports of the CR, Research of new detection systems based on sensor arrays for application in speciation analysis, Research and Development Programme KONTAKT (ME)
OC 179, research and development project
Name: Molekulární zobrazování založené na systémech obsahujících kovy.