Evaluation of cytotoxic activity of Schisandra chinensis
lignans

J 2010

Evaluation of cytotoxic activity of Schisandra chinensis lignans

SMEJKAL, Karel; Tereza SLAPETOVÁ; Pavel KRMENČÍK; Petr BABULA; Stefano DALL'ACQUA et al.

Základní údaje

Originální název

Evaluation of cytotoxic activity of Schisandra chinensis lignans

Název česky

Hodnocení cytotoxické aktivity lignanů Schisandra chinensis

Autoři

Vydání

Planta Medica, Stuttgart - New York, Thieme Medical Publishers, 2010, 0032-0943

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.369

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/10:00049173

Organizační jednotka

Lékařská fakulta

UT WoS

000283917300007

Klíčová slova česky

Schisandra chinensis; Schisandraceae; dibenzocyklooktadienové lignany; cytotoxicita; apoptóza

Klíčová slova anglicky

Schisandra chinensis; Schisandraceae; dibenzocyclooctadiene lignans; cytotoxicity; apoptosis

Změněno: 8. 1. 2011 21:11, Mgr. Jiří Slanina, Ph.D.

Anotace

ORIG CZ

V originále

Using exhaustive chromatographic separation we have isolated (-)-tigloyl-deangeloyl-gomisin F as a novel dibenzocyclooctadiene lignan from schisandra chinensis. With the help of HPLC, we further isolated (+)-schisandrin, (+)-deoxyschisandrin, (+)-gamma-schisandrin, (-)-gomisin J, (+)-gomisin A, (-)-gomisin N, (-)-tigloyl-gomisin P, (-)-wuweizisu C, (-)-gomisin D, rubrisandrin A, (-)-gomisin G, (+)-gomisin K (3) and (-)-schisantherin C. A full NMR description of (-)-schisantherin C was carried out with the aim to confirm previous reports of its structure. Compounds isolated were identified on the basis of UV, IR, (1)H- and (13)C-NMR and MS. The cytotoxicity of lignans was tested for the BY-2 cell line alone and as a synergistic effect with the cytotoxic agent camptothecin. Lignans showed various toxicity and synergistic and antagonistic effects on camptothecin-induced cytotoxicity. Cytotoxicity against colon cancer cell line LoVo was also tested.

Česky

Cytotoxicita lignanů byla testována na linii BY-2 a synergický effekt pomocí cytotoxického agens kamptotecinu

Návaznosti

GA522/07/0995, projekt VaV

Název: Regulace biosyntézy sekundarních metabolitů v buněčné kultuře Schisandra chinensis

Investor: Grantová agentura ČR, Regulace biosyntézy sekundárních metabolitů v buněčné kultuře Schisandra chinensis

Citovat

SMEJKAL, Karel; Tereza SLAPETOVÁ; Pavel KRMENČÍK; Petr BABULA; Stefano DALL'ACQUA; Gabbriella INNOCENTI; Jan VANČO; Elisabetta CASARIN; Maria CARRARA; Karolina KALVAROVÁ; Margita DVORSKÁ; Jiří SLANINA; Eva KRAMÁŘOVÁ; Ondřej JULÍNEK a Marie URBANOVÁ. Evaluation of cytotoxic activity of Schisandra chinensis lignans. Planta Medica. Stuttgart - New York: Thieme Medical Publishers, 2010, roč. 76, č. 15, s. 1672-1677. ISSN 0032-0943.

@article{917543,
   author = {Smejkal, Karel and Slapetová, Tereza and Krmenčík, Pavel and Babula, Petr and Dall'Acqua, Stefano and Innocenti, Gabbriella and Vančo, Jan and Casarin, Elisabetta and Carrara, Maria and Kalvarová, Karolina and Dvorská, Margita and Slanina, Jiří and Kramářová, Eva and Julínek, Ondřej and Urbanová, Marie},
   article_location = {Stuttgart - New York},
   article_number = {15},
   keywords = {Schisandra chinensis; Schisandraceae; dibenzocyclooctadiene lignans; cytotoxicity; apoptosis},
   language = {eng},
   issn = {0032-0943},
   journal = {Planta Medica},
   title = {Evaluation of cytotoxic activity of Schisandra chinensis lignans},
   volume = {76},
   year = {2010}
}

TY  - JOUR
ID  - 917543
AU  - Smejkal, Karel - Slapetová, Tereza - Krmenčík, Pavel - Babula, Petr - Dall'Acqua, Stefano - Innocenti, Gabbriella - Vančo, Jan - Casarin, Elisabetta - Carrara, Maria - Kalvarová, Karolina - Dvorská, Margita - Slanina, Jiří - Kramářová, Eva - Julínek, Ondřej - Urbanová, Marie
PY  - 2010
TI  - Evaluation of cytotoxic activity of Schisandra chinensis lignans
JF  - Planta Medica
VL  - 76
IS  - 15
SP  - 1672-1677
EP  - 1672-1677
PB  - Thieme Medical Publishers
SN  - 00320943
KW  - Schisandra chinensis
KW  - Schisandraceae
KW  - dibenzocyclooctadiene lignans
KW  - cytotoxicity
KW  - apoptosis
N2  - Using exhaustive chromatographic separation we have isolated (-)-tigloyl-deangeloyl-gomisin F as a novel dibenzocyclooctadiene lignan from schisandra chinensis. With the help of HPLC, we further isolated (+)-schisandrin, (+)-deoxyschisandrin, (+)-gamma-schisandrin, (-)-gomisin J, (+)-gomisin A, (-)-gomisin N, (-)-tigloyl-gomisin P, (-)-wuweizisu C, (-)-gomisin D, rubrisandrin A, (-)-gomisin G, (+)-gomisin K (3) and (-)-schisantherin C. A full NMR description of (-)-schisantherin C was carried out with the aim to confirm previous reports of its structure. Compounds isolated were identified on the basis of UV, IR, (1)H- and (13)C-NMR and MS. The cytotoxicity of lignans was tested for the BY-2 cell line alone and as a synergistic effect with the cytotoxic agent camptothecin. Lignans showed various toxicity and synergistic and antagonistic effects on camptothecin-induced cytotoxicity. Cytotoxicity against colon cancer cell line LoVo was also tested.
ER  -

SMEJKAL, Karel; Tereza SLAPETOVÁ; Pavel KRMENČÍK; Petr BABULA; Stefano DALL'ACQUA; Gabbriella INNOCENTI; Jan VANČO; Elisabetta CASARIN; Maria CARRARA; Karolina KALVAROVÁ; Margita DVORSKÁ; Jiří SLANINA; Eva KRAMÁŘOVÁ; Ondřej JULÍNEK a Marie URBANOVÁ. Evaluation of cytotoxic activity of Schisandra chinensis lignans. \textit{Planta Medica}. Stuttgart - New York: Thieme Medical Publishers, 2010, roč.~76, č.~15, s.~1672-1677. ISSN~0032-0943.

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