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@article{917543,
author = {Smejkal, Karel and Slapetová, Tereza and Krmenčík, Pavel and Babula, Petr and Dall'Acqua, Stefano and Innocenti, Gabbriella and Vančo, Jan and Casarin, Elisabetta and Carrara, Maria and Kalvarová, Karolina and Dvorská, Margita and Slanina, Jiří and Kramářová, Eva and Julínek, Ondřej and Urbanová, Marie},
article_location = {Stuttgart - New York},
article_number = {15},
keywords = {Schisandra chinensis; Schisandraceae; dibenzocyclooctadiene lignans; cytotoxicity; apoptosis},
language = {eng},
issn = {0032-0943},
journal = {Planta Medica},
title = {Evaluation of cytotoxic activity of Schisandra chinensis lignans},
volume = {76},
year = {2010}
}
TY - JOUR
ID - 917543
AU - Smejkal, Karel - Slapetová, Tereza - Krmenčík, Pavel - Babula, Petr - Dall'Acqua, Stefano - Innocenti, Gabbriella - Vančo, Jan - Casarin, Elisabetta - Carrara, Maria - Kalvarová, Karolina - Dvorská, Margita - Slanina, Jiří - Kramářová, Eva - Julínek, Ondřej - Urbanová, Marie
PY - 2010
TI - Evaluation of cytotoxic activity of Schisandra chinensis lignans
JF - Planta Medica
VL - 76
IS - 15
SP - 1672-1677
EP - 1672-1677
PB - Thieme Medical Publishers
SN - 00320943
KW - Schisandra chinensis
KW - Schisandraceae
KW - dibenzocyclooctadiene lignans
KW - cytotoxicity
KW - apoptosis
N2 - Using exhaustive chromatographic separation we have isolated (-)-tigloyl-deangeloyl-gomisin F as a novel dibenzocyclooctadiene lignan from schisandra chinensis. With the help of HPLC, we further isolated (+)-schisandrin, (+)-deoxyschisandrin, (+)-gamma-schisandrin, (-)-gomisin J, (+)-gomisin A, (-)-gomisin N, (-)-tigloyl-gomisin P, (-)-wuweizisu C, (-)-gomisin D, rubrisandrin A, (-)-gomisin G, (+)-gomisin K (3) and (-)-schisantherin C. A full NMR description of (-)-schisantherin C was carried out with the aim to confirm previous reports of its structure. Compounds isolated were identified on the basis of UV, IR, (1)H- and (13)C-NMR and MS. The cytotoxicity of lignans was tested for the BY-2 cell line alone and as a synergistic effect with the cytotoxic agent camptothecin. Lignans showed various toxicity and synergistic and antagonistic effects on camptothecin-induced cytotoxicity. Cytotoxicity against colon cancer cell line LoVo was also tested.
ER -
SMEJKAL, Karel, Tereza SLAPETOVÁ, Pavel KRMENČÍK, Petr BABULA, Stefano DALL'ACQUA, Gabbriella INNOCENTI, Jan VANČO, Elisabetta CASARIN, Maria CARRARA, Karolina KALVAROVÁ, Margita DVORSKÁ, Jiří SLANINA, Eva KRAMÁŘOVÁ, Ondřej JULÍNEK a Marie URBANOVÁ. Evaluation of cytotoxic activity of Schisandra chinensis lignans. \textit{Planta Medica}. Stuttgart - New York: Thieme Medical Publishers, 2010, roč.~76, č.~15, s.~1672-1677. ISSN~0032-0943.
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