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@proceedings{918523,
author = {Beníšek, Martin and Richterová, Martina and Kubincová, Petra and Hilscherová, Klára},
booktitle = {XII International Congress of Toxicology, IUTOX 2010, Barcelona, Spain},
keywords = {retinoids; personal care products; PAHs; N-PAHs},
language = {eng},
title = {Interference of some environmental contaminants with retinoid signaling in vitro},
url = {http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCR-501F18P-FN&_user=835458&_coverDate=07%2F17%2F2010&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000045159&_version=1&_urlVersion=0&_userid=835458&md5=fa46df4},
year = {2010}
}
TY - CONF
ID - 918523
AU - Beníšek, Martin - Richterová, Martina - Kubincová, Petra - Hilscherová, Klára
PY - 2010
TI - Interference of some environmental contaminants with retinoid signaling in vitro
KW - retinoids
KW - personal care products
KW - PAHs
KW - N-PAHs
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCR-501F18P-FN&_user=835458&_coverDate=07%2F17%2F2010&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000045159&_version=1&_urlVersion=0&_userid=835458&md5=fa46df4
N2 - Retinoids are dietary hormones important during proliferation, differentiation and apoptosis.They act mainly through nuclear receptors for retinoic acid, RARs and RXRs. Disruption of these signaling pathways can lead to several adverse effects especially during embryonic development. Using pluripotent P19/A15 cell we tested whether some polycyclic aromatic hydrocarbons (PAHs), their N-heterocyclic analogs and some personal care products(UV filters, parabens) can interfere with retinoid signaling. Studied compounds were tested for direct activation of RAR/RXR signaling pathway, but also modulation of the response of natural ligand all-trans retinoic acid (ATRA) by studied compounds was tested. No direct activation was found for studied PAHs and N-PAHs, however, some of these compounds modulated the response of ATRA. Downregulation of the response was observed mostly for 2 and 3-ring N-PAHs, while 4 and 5-ring PAHs and N-PAHs mostly up-regulated the response of ATRA. Interference of personal care products with retinoid signaling in P19/A15 assay is further discussed in the second part of this study.
ER -
BENÍŠEK, Martin, Martina RICHTEROVÁ, Petra KUBINCOVÁ a Klára HILSCHEROVÁ. Interference of some environmental contaminants with retinoid signaling in vitro. In \textit{XII International Congress of Toxicology, IUTOX 2010, Barcelona, Spain}. 2010.
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