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@article{918900,
author = {Mikulková, Zuzana and Praksová, Petra and Štourač, Pavel and Bednařík, Josef and Michálek, Jaroslav},
article_location = {Netherlands},
article_number = {1-2},
doi = {http://dx.doi.org/10.1016/j.jns.2010.08.053},
keywords = {multiple sclerosis; T-cells; memory cells; cytokines; flow cytometry},
language = {eng},
issn = {0022-510X},
journal = {Journal of the neurological sciences},
title = {Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis},
volume = {300},
year = {2011}
}
TY - JOUR
ID - 918900
AU - Mikulková, Zuzana - Praksová, Petra - Štourač, Pavel - Bednařík, Josef - Michálek, Jaroslav
PY - 2011
TI - Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis
JF - Journal of the neurological sciences
VL - 300
IS - 1-2
SP - 135-141
EP - 135-141
PB - Amsterdam : Elsevier
SN - 0022510X
KW - multiple sclerosis
KW - T-cells
KW - memory cells
KW - cytokines
KW - flow cytometry
N2 - In the present study, T-lymphocyte populations and pro-inflammatory as well as suppressive cytokine profiles were evaluated in detail in previously untreated patients with relapsing-remitting multiple sclerosis (RRMS). CD4(+) and CD8(+) naive, central memory (Tcm), effector memory (Tem), terminal effector memory (Ttem), CD4(+) regulatory T-cells (Treg) and CD8(+) T-suppressor cells (Ts) were analysed using flow cytometry, and levels of ten plasma cytokines were determined using fluorescent bead-based immunoassay. We evaluated two groups of RRMS with minor (n=33) and major (n=25) clinical impairment and compared them with healthy controls (n=40) in order to detect any correlation between severity of MS clinical symptoms and immune disturbances. In conclusion, we demonstrate complex immune dysbalances in untreated MS patients.
ER -
MIKULKOVÁ, Zuzana, Petra PRAKSOVÁ, Pavel ŠTOURAČ, Josef BEDNAŘÍK a Jaroslav MICHÁLEK. Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis. \textit{Journal of the neurological sciences}. Netherlands: Amsterdam : Elsevier, 2011, roč.~300, 1-2, s.~135-141. ISSN~0022-510X. Dostupné z: https://dx.doi.org/10.1016/j.jns.2010.08.053.
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