| PAŘENICA, Jiří, Monika PÁVKOVÁ GOLDBERGOVÁ, Petr KALA, Martin POLOCZEK, Jan MAŇOUŠEK, Krystyna PRYMUSOVÁ, Lenka KUBKOVÁ, Jiří JARKOVSKÝ, D. TOMČÍKOVÁ, Ondřej TOMAN, Martin TESÁK, Josef TOMANDL, Anna VAŠKŮ a Jindřich ŠPINAR. ACE gene insertion/deletion polymorphism has a moderate influence on the acute development of left ventricular dysfunction in patients with ST elevation myocardial infarction treated with primary PCI. BMC Cardiovascular Disorders. BioMed Centrak ltd., 2010, roč. 10, č. 60, 8 s. ISSN 1471-2261. |
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@article{919825,
author = {Pařenica, Jiří and Pávková Goldbergová, Monika and Kala, Petr and Poloczek, Martin and Maňoušek, Jan and Prymusová, Krystyna and Kubková, Lenka and Jarkovský, Jiří and Tomčíková, D. and Toman, Ondřej and Tesák, Martin and Tomandl, Josef and Vašků, Anna and Špinar, Jindřich},
article_number = {60},
keywords = {ACE; polymorphism; gene; myocardial infarction},
language = {eng},
issn = {1471-2261},
journal = {BMC Cardiovascular Disorders},
title = {ACE gene insertion/deletion polymorphism has a moderate influence on the acute development of left ventricular dysfunction in patients with ST elevation myocardial infarction treated with primary PCI},
volume = {10},
year = {2010}
}
TY - JOUR
ID - 919825
AU - Pařenica, Jiří - Pávková Goldbergová, Monika - Kala, Petr - Poloczek, Martin - Maňoušek, Jan - Prymusová, Krystyna - Kubková, Lenka - Jarkovský, Jiří - Tomčíková, D. - Toman, Ondřej - Tesák, Martin - Tomandl, Josef - Vašků, Anna - Špinar, Jindřich
PY - 2010
TI - ACE gene insertion/deletion polymorphism has a moderate influence on the acute development of left ventricular dysfunction in patients with ST elevation myocardial infarction treated with primary PCI
JF - BMC Cardiovascular Disorders
VL - 10
IS - 60
PB - BioMed Centrak ltd.
SN - 14712261
KW - ACE
KW - polymorphism
KW - gene
KW - myocardial infarction
N2 - We evaluated the associations among angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism, ACE activity and post-myocardial infarction left ventricular dysfunction and acute heart failure early after presentation with MI with ST-segment elevation. A total of 556 patients with STEMI treated by primary PCI were the study population. The DD/ID genotypes were associated with a significantly higher risk of EF. These results suggest that the I/D polymorphism of ACE is associated with the development of LV dysfunction in the acute phase after STEMI. We demonstrated for the first time an association of the low ACE activity with the severe LV dysfunction, although patients with moderate LV dysfunction had higher level ACE activity than patients with preserved LV function.
ER -
PAŘENICA, Jiří, Monika PÁVKOVÁ GOLDBERGOVÁ, Petr KALA, Martin POLOCZEK, Jan MAŇOUŠEK, Krystyna PRYMUSOVÁ, Lenka KUBKOVÁ, Jiří JARKOVSKÝ, D. TOMČÍKOVÁ, Ondřej TOMAN, Martin TESÁK, Josef TOMANDL, Anna VAŠKŮ a Jindřich ŠPINAR. ACE gene insertion/deletion polymorphism has a moderate influence on the acute development of left ventricular dysfunction in patients with ST elevation myocardial infarction treated with primary PCI. \textit{BMC Cardiovascular Disorders}. BioMed Centrak ltd., 2010, roč.~10, č.~60, 8 s. ISSN~1471-2261.
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