2009
Echocardiographic analysis of increased natriuretic peptides plasma levels in patients with hypertension and metabolic syndrome
ŠPÁC, Jiří, Helena NĚMCOVÁ a Miroslav SOUČEKZákladní údaje
Originální název
Echocardiographic analysis of increased natriuretic peptides plasma levels in patients with hypertension and metabolic syndrome
Název česky
Echokardiografická analýza nemocných se zvýšenou hodnotou natriuretických peptidů u nemocných s hypertenzí a metabolickým syndromem
Název anglicky
Echocardiographic analysis of increased natriuretic peptides plasma levels in patients with hypertension and metabolic syndrome
Autoři
ŠPÁC, Jiří (203 Česká republika, garant, domácí), Helena NĚMCOVÁ (203 Česká republika, domácí) a Miroslav SOUČEK (203 Česká republika, domácí)
Vydání
19th European Meeting on Hypertension, 2009
Další údaje
Jazyk
čeština
Typ výsledku
Konferenční abstrakt
Obor
30201 Cardiac and Cardiovascular systems
Stát vydavatele
Česká republika
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 4.988
Kód RIV
RIV/00216224:14110/09:00046858
Organizační jednotka
Lékařská fakulta
ISSN
UT WoS
000269443600353
Klíčová slova česky
natriuretické peptdy hypertenze
Klíčová slova anglicky
natriuretic peptides hypertension
Štítky
Změněno: 17. 1. 2011 10:50, doc. MUDr. Jiří Špác, CSc.
V originále
Aim of the study was the comparison of natriuretic peptides (NP) and type of left ventricular remodelation with the help of echocardiography (echo) for the determination of diastolic left ventricular (LV) dysfunction in patients (pts) with hypertension (HT) and metabolic syndrome( MS) Methods: We have evaluated plasma levels of BNP and NT pro BNP in 141 pts with HT of 1st degrese with MS (group A, mean age 53,6 years, BP 140/93,5 mmHg, BMI 35,4) with normal renal function and without sign sof ischemic heart disease with normal LV systolic function. Echo included 2-D imaging of the LV with evaluation of ejection fraction (EF), left atrial (LA), pulsed doppler assessment of transmitral blood flow velocities (Wales E,A) and pulsed doppler imaging (TDI) of mitral anulus motions (Em, Am, Sm) Results: We have found different levels of BNP, NT pro BNP in pts with LV hypertrophy and those with normal LV mass (134,0 resp 311 pg/ml agains 64,0 resp 69 pg/ml, p < 0,001) The highest BNP resp NT pro BNP were in the group of 25 pts with concentric LV hypertrophy (150 resp 335 pg/ml.In 30 pts with eccentic LV hypertrophy (117 resp 287 pg/ml. In the group of asymetric LV hypertrophy there was no diference in comparison with the group of normal LV parametrs. NP levels have correlated with the occurence of more severe forms of diastolic dysfunction with E/Em ratio, reflecting higher filling pressures of LV (r=0,808 for NT pro BNP resp. 0,786 for BNP, p < 0,001) Conclusion: NP evaluation seems to be applicable for risk stratification of pts with HT and MS where the occurence of more severe forms of diastolic dysfunction reaches 30%. NP are not useful for the detection of mild LV dysfunction in asymptomatic pts and are able to reveal only severe forms of LV diastolic dysfunction. .
Anglicky
Aim of the study was the comparison of natriuretic peptides (NP) and type of left ventricular remodelation with the help of echocardiography (echo) for the determination of diastolic left ventricular (LV) dysfunction in patients (pts) with hypertension (HT) and metabolic syndrome( MS) Methods: We have evaluated plasma levels of BNP and NT pro BNP in 141 pts with HT of 1st degrese with MS (group A, mean age 53,6 years, BP 140/93,5 mmHg, BMI 35,4) with normal renal function and without sign sof ischemic heart disease with normal LV systolic function. Echo included 2-D imaging of the LV with evaluation of ejection fraction (EF), left atrial (LA), pulsed doppler assessment of transmitral blood flow velocities (Wales E,A) and pulsed doppler imaging (TDI) of mitral anulus motions (Em, Am, Sm) Results: We have found different levels of BNP, NT pro BNP in pts with LV hypertrophy and those with normal LV mass (134,0 resp 311 pg/ml agains 64,0 resp 69 pg/ml, p < 0,001) The highest BNP resp NT pro BNP were in the group of 25 pts with concentric LV hypertrophy (150 resp 335 pg/ml.In 30 pts with eccentic LV hypertrophy (117 resp 287 pg/ml. In the group of asymetric LV hypertrophy there was no diference in comparison with the group of normal LV parametrs. NP levels have correlated with the occurence of more severe forms of diastolic dysfunction with E/Em ratio, reflecting higher filling pressures of LV (r=0,808 for NT pro BNP resp. 0,786 for BNP, p < 0,001) Conclusion: NP evaluation seems to be applicable for risk stratification of pts with HT and MS where the occurence of more severe forms of diastolic dysfunction reaches 30%. NP are not useful for the detection of mild LV dysfunction in asymptomatic pts and are able to reveal only severe forms of LV diastolic dysfunction. .
Návaznosti
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