Physiological consequences of ion concentration changes in
transverse-axial tubular system in a model of human ventricular
cardiomyocyte

J 2010

Physiological consequences of ion concentration changes in transverse-axial tubular system in a model of human ventricular cardiomyocyte

OHLÍDALOVÁ, Dana; Michal PÁSEK; Jiří ŠIMURDA a Georges CHRISTÉ

Základní údaje

Originální název

Physiological consequences of ion concentration changes in transverse-axial tubular system in a model of human ventricular cardiomyocyte

Název česky

Fyziologické důsledky iontově-koncentračních změn v transverzálně-axiálním tubulárním systému v modelu lidské srdeční komorové buňky

Autoři

OHLÍDALOVÁ, Dana; Michal PÁSEK; Jiří ŠIMURDA a Georges CHRISTÉ

Vydání

Analysis of Biomedical Signals and Images, Brno, VUTIUM Press, 2010, 1211-412X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10610 Biophysics

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/10:00051747

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

cardiac cell; transverse-axial tubular system; quantitative model

Štítky

accumulation-depletion of ions, Cardiac cell

Změněno: 10. 4. 2012 08:05, Mgr. Michal Petr

Anotace

V originále

A mathematical model of human ventricular cell incorporating the transverse axial tubular system (TATS) was designed and used to explore the role of TATS in human ventricular cell electrophysiological activity. The model is based on the latest quantitative description of guinea pig ventricular cell electrophysiology and modified to respect the published data obtained from human cardiac preparations. Computer simulations suggest that significant transient depletions of Ca2+ ions and accumulation of K+ ions may occur in the human TATS. The preliminary analysis of the effects of tubular Ca2+depletions on the activity of the model cell indicates their role in limitation of intracellular Ca2+ overload at higher frequencies of stimulation.

Návaznosti

MSM0021622402, záměr

Název: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Časná diagnostika a léčba kardiovaskulárních chorob

Citovat

OHLÍDALOVÁ, Dana; Michal PÁSEK; Jiří ŠIMURDA a Georges CHRISTÉ. Physiological consequences of ion concentration changes in transverse-axial tubular system in a model of human ventricular cardiomyocyte. Analysis of Biomedical Signals and Images. Brno: VUTIUM Press, 2010, roč. 20, č. 1, s. 114-117. ISSN 1211-412X.

@article{921409,
   author = {Ohlídalová, Dana and Pásek, Michal and Šimurda, Jiří and Christé, Georges},
   article_location = {Brno},
   article_number = {1},
   keywords = {cardiac cell; transverse-axial tubular system; quantitative model},
   language = {eng},
   issn = {1211-412X},
   journal = {Analysis of Biomedical Signals and Images},
   title = {Physiological consequences of ion concentration changes in transverse-axial tubular system in a model of human ventricular cardiomyocyte},
   volume = {20},
   year = {2010}
}

TY  - JOUR
ID  - 921409
AU  - Ohlídalová, Dana - Pásek, Michal - Šimurda, Jiří - Christé, Georges
PY  - 2010
TI  - Physiological consequences of ion concentration changes in transverse-axial tubular system in a model of human ventricular cardiomyocyte
JF  - Analysis of Biomedical Signals and Images
VL  - 20
IS  - 1
SP  - 114-117
EP  - 114-117
PB  - VUTIUM Press
SN  - 1211412X
KW  - cardiac cell
KW  - transverse-axial tubular system
KW  - quantitative model
N2  - A mathematical model of human ventricular cell incorporating the transverse axial tubular system (TATS) was designed and used to explore the role of TATS in human ventricular cell electrophysiological activity. The model is based on the latest quantitative description of guinea pig ventricular cell electrophysiology and modified to respect the published data obtained from human cardiac preparations. Computer simulations suggest that significant transient depletions of Ca2+ ions and accumulation of K+ ions may occur in the human TATS. The preliminary analysis of the effects of tubular Ca2+depletions on the activity of the model cell indicates their role in limitation of intracellular Ca2+ overload at higher frequencies of stimulation.
ER  -

OHLÍDALOVÁ, Dana; Michal PÁSEK; Jiří ŠIMURDA a Georges CHRISTÉ. Physiological consequences of ion concentration changes in transverse-axial tubular system in a model of human ventricular cardiomyocyte. \textit{Analysis of Biomedical Signals and Images}. Brno: VUTIUM Press, 2010, roč.~20, č.~1, s.~114-117. ISSN~1211-412X.

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