MMP-13 polymorphism (rs640198) in patients with confirmed CAD

a 2011

MMP-13 polymorphism (rs640198) in patients with confirmed CAD

VAŠKŮ, Anna; Jiří BLAHÁK; Monika PÁVKOVÁ GOLDBERGOVÁ; Iva BARTOŇOVÁ; Vladimír KINCL et al.

Základní údaje

Originální název

MMP-13 polymorphism (rs640198) in patients with confirmed CAD

Název česky

Polymorfismus v genu pro MMP-13 (rs640198) u pacientlů s potvrzenou nemocí koronárních artérií

Autoři

VAŠKŮ, Anna; Jiří BLAHÁK; Monika PÁVKOVÁ GOLDBERGOVÁ; Iva BARTOŇOVÁ; Vladimír KINCL a Jaroslav MELUZÍN

Vydání

ISP a SHR 2010, Montreal, Kanada, 2011

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30105 Physiology

Stát vydavatele

Kanada

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

Klíčová slova česky

MMP-13 polymorfismus CAD

Klíčová slova anglicky

MMP-13 polymorphism CAD

Změněno: 20. 1. 2011 09:56, prof. MUDr. Anna Vašků, CSc.

Anotace

ORIG CZ

V originále

The genetic background that underlies the susceptibility, occurrence and severity of CAD is still poorly elucidated. MMP-13 was proposed as another possible candidate for the NO-mediated prevention of atherosclerosis. The study comprised 1071 consecutive patients, 734 men and 337 women, median age 48 years, with suspected or known CAD referred for coronary angiography. During the short-term hospitalization the patients underwent full cardiologic investigation (history, physical examination, electrocardiography, laboratory examination, coronary angiography, echocardiography in patients with unclear diagnosis). The study was approved by the institutional ethics committee; informed consent of all patients is archived. The intron G/T polymorphism (rs640198) in MMP-13 gene was detected by TaqMan SNP genotyping. A significant difference in the MMP-13 polymorphism was observed between patients with clinically manifest coronary artery diseases (CAD) compared to those without the disease (Pg =0. 06, Pa=0.02). As a result of the multivariate analysis, significant interaction between MMP-13 polymorphism and the total number of stenoses was observed when EF LV and HR had been included as dependent continuous variables (P=0.03, power test = 96%). In detail, the TT genotype of MMP-13 differs from GG and GT genotypes whose EF LV gradually drops with higher number of stenoses. The values of heart rate are more oscillating in patients with the TT genotype. The TT genotype of MMP-13 polymorphism is associated with different hemodynamic characteristics compared to the other genotypes of the polymorphism in patients with coronary artery disease.

Česky

Prokázali jsme signifikantní asociaci mezi alelou T polymorfismu rs604198 a počtem postižených tepen u pacientů s koronarograficky verifikovanou CAD.

Citovat

VAŠKŮ, Anna; Jiří BLAHÁK; Monika PÁVKOVÁ GOLDBERGOVÁ; Iva BARTOŇOVÁ; Vladimír KINCL a Jaroslav MELUZÍN. MMP-13 polymorphism (rs640198) in patients with confirmed CAD. In ISP a SHR 2010, Montreal, Kanada. 2011.

@proceedings{921468,
   author = {Vašků, Anna and Blahák, Jiří and Pávková Goldbergová, Monika and Bartoňová, Iva and Kincl, Vladimír and Meluzín, Jaroslav},
   booktitle = {ISP a SHR 2010, Montreal, Kanada},
   keywords = {MMP-13 polymorphism CAD},
   language = {eng},
   title = {MMP-13 polymorphism (rs640198) in patients with confirmed CAD},
   year = {2011}
}

TY  - CONF
ID  - 921468
AU  - Vašků, Anna - Blahák, Jiří - Pávková Goldbergová, Monika - Bartoňová, Iva - Kincl, Vladimír - Meluzín, Jaroslav
PY  - 2011
TI  - MMP-13 polymorphism (rs640198) in patients with confirmed CAD
KW  - MMP-13 polymorphism CAD
N2  - The genetic background that underlies the susceptibility, occurrence and severity of CAD is still poorly elucidated. MMP-13 was proposed as another possible candidate for the NO-mediated prevention of atherosclerosis. The study comprised 1071 consecutive patients, 734 men and 337 women, median age 48 years, with suspected or known CAD referred for coronary angiography. During the short-term hospitalization the patients underwent full cardiologic investigation (history, physical examination, electrocardiography, laboratory examination, coronary angiography, echocardiography in patients with unclear diagnosis). The study was approved by the institutional ethics committee; informed consent of all patients is archived. The intron G/T polymorphism (rs640198) in MMP-13 gene was detected by TaqMan SNP genotyping. A significant difference in the MMP-13 polymorphism was observed between patients with clinically manifest coronary artery diseases (CAD) compared to those without the disease (Pg =0. 06, Pa=0.02). As a result of the multivariate analysis, significant interaction between MMP-13 polymorphism and the total number of stenoses was observed when EF LV and HR had been included as dependent continuous variables (P=0.03, power test = 96%). In detail, the TT genotype of MMP-13 differs from GG and GT genotypes whose EF LV gradually drops with higher number of stenoses. The values of heart rate are more oscillating in patients with the TT genotype. The TT genotype of MMP-13 polymorphism is associated with different hemodynamic characteristics compared to the other genotypes of the polymorphism in patients with coronary artery disease.
ER  -

VAŠKŮ, Anna; Jiří BLAHÁK; Monika PÁVKOVÁ GOLDBERGOVÁ; Iva BARTOŇOVÁ; Vladimír KINCL a Jaroslav MELUZÍN. MMP-13 polymorphism (rs640198) in patients with confirmed CAD. In \textit{ISP a SHR 2010, Montreal, Kanada}. 2011.

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