| DVOŘÁK, Martin, Michal VLAŠÍN, Martina DVOŘÁKOVÁ, Petr RAUŠER, Leona LEXMAULOVÁ, Zdeněk GREGOR a Robert STAFFA. Heparin and its derivatives in the treatment of arterial thrombosis: a review. Veterinární medicína. Praha: ÚZPI, 2010, roč. 55, č. 11, s. 523–546. ISSN 0375-8427. |
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@article{921549,
author = {Dvořák, Martin and Vlašín, Michal and Dvořáková, Martina and Raušer, Petr and Lexmaulová, Leona and Gregor, Zdeněk and Staffa, Robert},
article_location = {Praha},
article_number = {11},
keywords = {coagulation; arterial thrombosis; standard heparin; low-molecular weight heparins},
language = {eng},
issn = {0375-8427},
journal = {Veterinární medicína},
title = {Heparin and its derivatives in the treatment of arterial thrombosis: a review},
volume = {55},
year = {2010}
}
TY - JOUR
ID - 921549
AU - Dvořák, Martin - Vlašín, Michal - Dvořáková, Martina - Raušer, Petr - Lexmaulová, Leona - Gregor, Zdeněk - Staffa, Robert
PY - 2010
TI - Heparin and its derivatives in the treatment of arterial thrombosis: a review
JF - Veterinární medicína
VL - 55
IS - 11
SP - 523–546
EP - 523–546
PB - ÚZPI
SN - 03758427
KW - coagulation
KW - arterial thrombosis
KW - standard heparin
KW - low-molecular weight heparins
N2 - Arterial occlusion due to thrombosis caused by ruptured atherosclerotic plaques has been recognized as a major cause of morbidity and mortality in western populations. Along with chronic heart failure it significantly decreases patient life expectancy. The major goal of treatment remains fast recanalization and acute reocclusion prevention. Direct (antithrombin-independent) thrombin inhibitors can be divided into two main categories: monovalent and bivalent, while antithrombin stimulators represent standard (unfractionated) heparin (UFH) and its depolymerizing products - low molecular weight heparins (LMWH's). Recently a shift to prophylaxis of thromboembolic disease has been advocated. Unlike standard heparin, low-molecular weight heparins do not affect the patient's general coagulation profile. Obviously, the difference in molecular weight results in different pharmacokinetic and pharmacodynamic properties of the agents.
ER -
DVOŘÁK, Martin, Michal VLAŠÍN, Martina DVOŘÁKOVÁ, Petr RAUŠER, Leona LEXMAULOVÁ, Zdeněk GREGOR a Robert STAFFA. Heparin and its derivatives in the treatment of arterial thrombosis: a review. \textit{Veterinární medicína}. Praha: ÚZPI, 2010, roč.~55, č.~11, s.~523–546. ISSN~0375-8427.
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