Pharmaceutical importance of zinc and metallothionein in cell
signaling.

J 2010

Pharmaceutical importance of zinc and metallothionein in cell signaling.

BABULA, Petr; Veronika KOHOUTKOVÁ; Radka OPATŘILOVÁ; Ivana DAŇKOVÁ; Michal MASAŘÍK et al.

Základní údaje

Originální název

Pharmaceutical importance of zinc and metallothionein in cell signaling.

Autoři

BABULA, Petr; Veronika KOHOUTKOVÁ; Radka OPATŘILOVÁ; Ivana DAŇKOVÁ; Michal MASAŘÍK a René KIZEK

Vydání

Chimica Oggi/Chemistry today, 2010, 0392-839X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Itálie

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.405

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/10:00040866

Organizační jednotka

Lékařská fakulta

UT WoS

000287167100005

Klíčová slova anglicky

Metalloprotein; Metal; Transporter; Pathogenesis; Cancer

Změněno: 20. 1. 2011 16:11, prof. RNDr. Michal Masařík, Ph.D.

Anotace

ORIG CZ

V originále

Zinc as an essential element plays the crucial role in many physiological, but also pathological processes - zinc controls cell proliferation, differentiation, and viability including the apoptosis. These facts are especially based on the structural role of zinc ions in many proteins including the transcription factors. Due to the role of zinc in many crucial physiological processes, its homeostasis must be intensively controlled. The controlling mechanisms are based especially on the zinc transporters and low-molecular proteins metallothioneins (MTs) of the molecular weight between 6 and 10 kDa, which were firstly discovered in a horse kidneys as the cadmium binding protein. High affinity of metallothioneins to the zinc ions indicates their significant participation in the physiological, but also pathological processes, which are controlled by zinc. This paper summarizes the connection between metallothioneins and zinc and its significance on the molecular basis.

Česky

Práce popisuje úlohu zinku ve vnitrobuněčné signalizaci.

Návaznosti

NS10200, projekt VaV

Název: Nádorové markery, jejich stanovení a korelace s karcinomem prostaty

Investor: Ministerstvo zdravotnictví ČR, Nádorové markery, jejich stanovení a korelace s karcinomem prostaty

Citovat

BABULA, Petr; Veronika KOHOUTKOVÁ; Radka OPATŘILOVÁ; Ivana DAŇKOVÁ; Michal MASAŘÍK a René KIZEK. Pharmaceutical importance of zinc and metallothionein in cell signaling. Chimica Oggi/Chemistry today. 2010, roč. 28, č. 6, s. 18-21. ISSN 0392-839X.

@article{921713,
   author = {Babula, Petr and Kohoutková, Veronika and Opatřilová, Radka and Daňková, Ivana and Masařík, Michal and Kizek, René},
   article_number = {6},
   keywords = {Metalloprotein; Metal; Transporter; Pathogenesis; Cancer},
   language = {eng},
   issn = {0392-839X},
   journal = {Chimica Oggi/Chemistry today},
   title = {Pharmaceutical importance of zinc and metallothionein in cell signaling.},
   volume = {28},
   year = {2010}
}

TY  - JOUR
ID  - 921713
AU  - Babula, Petr - Kohoutková, Veronika - Opatřilová, Radka - Daňková, Ivana - Masařík, Michal - Kizek, René
PY  - 2010
TI  - Pharmaceutical importance of zinc and metallothionein in cell signaling.
JF  - Chimica Oggi/Chemistry today
VL  - 28
IS  - 6
SP  - 18-21
EP  - 18-21
SN  - 0392839X
KW  - Metalloprotein
KW  - Metal
KW  - Transporter
KW  - Pathogenesis
KW  - Cancer
N2  - Zinc as an essential element plays the crucial role in many physiological, but also pathological processes - zinc controls cell proliferation, differentiation, and viability including the apoptosis. These facts are especially based on the structural role of zinc ions in many proteins including the transcription factors. Due to the role of zinc in many crucial physiological processes, its homeostasis must be intensively controlled. The controlling mechanisms are based especially on the zinc transporters and low-molecular proteins metallothioneins (MTs) of the molecular weight between 6 and 10 kDa, which were firstly discovered in a horse kidneys as the cadmium binding protein. High affinity of metallothioneins to the zinc ions indicates their significant participation in the physiological, but also pathological processes, which are controlled by zinc. This paper summarizes the connection between metallothioneins and zinc and its significance on the molecular basis.
ER  -

BABULA, Petr; Veronika KOHOUTKOVÁ; Radka OPATŘILOVÁ; Ivana DAŇKOVÁ; Michal MASAŘÍK a René KIZEK. Pharmaceutical importance of zinc and metallothionein in cell signaling. \textit{Chimica Oggi/Chemistry today}. 2010, roč.~28, č.~6, s.~18-21. ISSN~0392-839X.

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