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@article{921829,
author = {Lipina, Radim and Reguli, Štefan and Nováčková, Ludmila and Podešvová, Hana and Brichtová, Eva},
article_number = {3},
keywords = {Posthemorrhagic hydrocephalus Endoscopic third ventriculostomy Transforming growth factor beta1 Premature infants},
language = {eng},
issn = {0256-7040},
journal = {Childs Nerv Syst},
title = {Relation between TGF-beta1 levels in cerebrospinal fluid and ETV outcome in premature newborns with posthemorrhagic hydrocephalus. Relation between TGF-ß1 levels in cerebrospinal fluid and ETV outcome},
volume = {26},
year = {2010}
}
TY - JOUR
ID - 921829
AU - Lipina, Radim - Reguli, Štefan - Nováčková, Ludmila - Podešvová, Hana - Brichtová, Eva
PY - 2010
TI - Relation between TGF-beta1 levels in cerebrospinal fluid and ETV outcome in premature newborns with posthemorrhagic hydrocephalus. Relation between TGF-ß1 levels in cerebrospinal fluid and ETV outcome
JF - Childs Nerv Syst
VL - 26
IS - 3
SP - 333-341
EP - 333-341
SN - 02567040
KW - Posthemorrhagic hydrocephalus Endoscopic third ventriculostomy Transforming growth factor beta1 Premature infants
N2 - Though pathophysiology of PHH is more complicated and TGF-beta1 is not the only one to play a role in it, we have documented in our study that TGF-beta1 level in CSF collected in the beginning of temporary treatment of PHH correlates with failure of CSF resorption. In our study, in 62.5% of patients with proof of obstruction, hyporesorptive component was present. Overall, ETV success rate in therapy of obstructive PHH 37.5% in our study. We have proven that premature newborns with lower TGF-beta1 level and proof of obstructive HDC on MRI have significantly higer success rate of endoscopic treatment. In our study, ETV success rate was 100% in this group. Our results show that TGF-beta1 may influence succes rate of ETV in treatment of PHH, and based on its levels, it is possible to choose patients with purely obstructive hydrocephalus.
ER -
LIPINA, Radim, Štefan REGULI, Ludmila NOVÁČKOVÁ, Hana PODEŠVOVÁ a Eva BRICHTOVÁ. Relation between TGF-beta1 levels in cerebrospinal fluid and ETV outcome in premature newborns with posthemorrhagic hydrocephalus. Relation between TGF-ß1 levels in cerebrospinal fluid and ETV outcome. \textit{Childs Nerv Syst}. 2010, roč.~26, č.~3, s.~333-341. ISSN~0256-7040.
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