Relation between TGF-beta1 levels in cerebrospinal fluid and
ETV outcome in premature newborns with posthemorrhagic
hydrocephalus. Relation between TGF-ß1 levels in cerebrospinal
fluid and ETV outcome

J 2010

Relation between TGF-beta1 levels in cerebrospinal fluid and ETV outcome in premature newborns with posthemorrhagic hydrocephalus. Relation between TGF-ß1 levels in cerebrospinal fluid and ETV outcome

LIPINA, Radim, Štefan REGULI, Ludmila NOVÁČKOVÁ, Hana PODEŠVOVÁ, Eva BRICHTOVÁ et. al.

Základní údaje

Originální název

Relation between TGF-beta1 levels in cerebrospinal fluid and ETV outcome in premature newborns with posthemorrhagic hydrocephalus. Relation between TGF-ß1 levels in cerebrospinal fluid and ETV outcome

Autoři

LIPINA, Radim (203 Česká republika, garant), Štefan REGULI (203 Česká republika), Ludmila NOVÁČKOVÁ (203 Česká republika), Hana PODEŠVOVÁ (203 Česká republika) a Eva BRICHTOVÁ (203 Česká republika, domácí)

Vydání

Childs Nerv Syst, 2010, 0256-7040

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.314

Kód RIV

RIV/00216224:14110/10:00047019

Organizační jednotka

Lékařská fakulta

UT WoS

000274500800009

Klíčová slova anglicky

Posthemorrhagic hydrocephalus Endoscopic third ventriculostomy Transforming growth factor beta1 Premature infants

Změněno: 27. 2. 2011 20:13, prof. MUDr. Eva Brichtová, Ph.D.

Anotace

V originále

Though pathophysiology of PHH is more complicated and TGF-beta1 is not the only one to play a role in it, we have documented in our study that TGF-beta1 level in CSF collected in the beginning of temporary treatment of PHH correlates with failure of CSF resorption. In our study, in 62.5% of patients with proof of obstruction, hyporesorptive component was present. Overall, ETV success rate in therapy of obstructive PHH 37.5% in our study. We have proven that premature newborns with lower TGF-beta1 level and proof of obstructive HDC on MRI have significantly higer success rate of endoscopic treatment. In our study, ETV success rate was 100% in this group. Our results show that TGF-beta1 may influence succes rate of ETV in treatment of PHH, and based on its levels, it is possible to choose patients with purely obstructive hydrocephalus.

Citovat

LIPINA, Radim, Štefan REGULI, Ludmila NOVÁČKOVÁ, Hana PODEŠVOVÁ a Eva BRICHTOVÁ. Relation between TGF-beta1 levels in cerebrospinal fluid and ETV outcome in premature newborns with posthemorrhagic hydrocephalus. Relation between TGF-ß1 levels in cerebrospinal fluid and ETV outcome. Childs Nerv Syst. 2010, roč. 26, č. 3, s. 333-341. ISSN 0256-7040.

@article{921829,
   author = {Lipina, Radim and Reguli, Štefan and Nováčková, Ludmila and Podešvová, Hana and Brichtová, Eva},
   article_number = {3},
   keywords = {Posthemorrhagic hydrocephalus Endoscopic third ventriculostomy Transforming growth factor beta1 Premature infants},
   language = {eng},
   issn = {0256-7040},
   journal = {Childs Nerv Syst},
   title = {Relation between TGF-beta1 levels in cerebrospinal fluid and ETV outcome in premature newborns with posthemorrhagic hydrocephalus. Relation between TGF-ß1 levels in cerebrospinal fluid and ETV outcome},
   volume = {26},
   year = {2010}
}

TY  - JOUR
ID  - 921829
AU  - Lipina, Radim - Reguli, Štefan - Nováčková, Ludmila - Podešvová, Hana - Brichtová, Eva
PY  - 2010
TI  - Relation between TGF-beta1 levels in cerebrospinal fluid and ETV outcome in premature newborns with posthemorrhagic hydrocephalus. Relation between TGF-ß1 levels in cerebrospinal fluid and ETV outcome
JF  - Childs Nerv Syst
VL  - 26
IS  - 3
SP  - 333-341
EP  - 333-341
SN  - 02567040
KW  - Posthemorrhagic hydrocephalus Endoscopic third ventriculostomy Transforming growth factor beta1 Premature infants
N2  - Though pathophysiology of PHH is more complicated and TGF-beta1 is not the only one to play a role in it, we have documented in our study that TGF-beta1 level in CSF collected in the beginning of temporary treatment of PHH correlates with failure of CSF resorption. In our study, in 62.5% of patients with proof of obstruction, hyporesorptive component was present. Overall, ETV success rate in therapy of obstructive PHH 37.5% in our study. We have proven that premature newborns with lower TGF-beta1 level and proof of obstructive HDC on MRI have significantly higer success rate of endoscopic treatment. In our study, ETV success rate was 100% in this group. Our results show that TGF-beta1 may influence succes rate of ETV in treatment of PHH, and based on its levels, it is possible to choose patients with purely obstructive hydrocephalus.
ER  -

LIPINA, Radim, Štefan REGULI, Ludmila NOVÁČKOVÁ, Hana PODEŠVOVÁ a Eva BRICHTOVÁ. Relation between TGF-beta1 levels in cerebrospinal fluid and ETV outcome in premature newborns with posthemorrhagic hydrocephalus. Relation between TGF-ß1 levels in cerebrospinal fluid and ETV outcome. \textit{Childs Nerv Syst}. 2010, roč.~26, č.~3, s.~333-341. ISSN~0256-7040.

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