Matrix metalloproteinases.

J 2010

Matrix metalloproteinases.

ZÍTKA, Ondřej; Jiří KUKAČKA; Soňa KŘÍŽKOVÁ; Dalibor HÚSKA; Vojtěch ADAM et al.

Základní údaje

Originální název

Matrix metalloproteinases.

Autoři

ZÍTKA, Ondřej; Jiří KUKAČKA; Soňa KŘÍŽKOVÁ; Dalibor HÚSKA; Vojtěch ADAM; Michal MASAŘÍK; Richard PRŮŠA a René KIZEK

Vydání

Current Medicinal Chemistry, 2010, 0929-8673

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Spojené arabské emiráty

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.630

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/10:00040657

Organizační jednotka

Lékařská fakulta

UT WoS

000284714300011

Klíčová slova anglicky

matrix metalloproteinases; collagen; tissue inhibitors of matrix metalloproteinases; cysteine switch; zinc; metallothionein; tumour disease

Změněno: 21. 1. 2011 10:14, prof. RNDr. Michal Masařík, Ph.D.

Anotace

V originále

Matrix metalloproteinases (MMPs), also known as matrixins, belong to a group of zinc-dependent proteins, which are thought to play a central role in the breakdown of extracellular matrix. Collagen, elastin, gelatine and casein are major components cleaved by MMPs. The breakdown of these components is essential for many physiological processes such as embryonic development, morphogenesis, reproduction, and tissue resorption and remodelling. MMPs also participate in pathological processes such as arthritis, cancer, cardiovascular and neurological diseases. This review summarizes current knowledge regarding these proteins, their participation in physiological and pathophysiological roles, their involvement in activation and inhibition, and their interactions with other metal-binding proteins including metallothioneins.

Návaznosti

GP301/09/P436, projekt VaV

Název: Analýza metalothioneinu u karcinomu prostaty na úrovni DNA, RNA a proteinu.

Investor: Grantová agentura ČR, Analýza metalothioneinu u karcinomu prostaty na úrovni DNA, RNA a proteinu

IAA401990701, projekt VaV

Název: Studium vazby platinových cytostatik do struktury DNA; Vliv metalothioneinu

NS10200, projekt VaV

Název: Nádorové markery, jejich stanovení a korelace s karcinomem prostaty

Investor: Ministerstvo zdravotnictví ČR, Nádorové markery, jejich stanovení a korelace s karcinomem prostaty

Citovat

ZÍTKA, Ondřej; Jiří KUKAČKA; Soňa KŘÍŽKOVÁ; Dalibor HÚSKA; Vojtěch ADAM; Michal MASAŘÍK; Richard PRŮŠA a René KIZEK. Matrix metalloproteinases. Current Medicinal Chemistry. 2010, roč. 17, č. 31, 18 s. ISSN 0929-8673.

@article{921868,
   author = {Zítka, Ondřej and Kukačka, Jiří and Křížková, Soňa and Húska, Dalibor and Adam, Vojtěch and Masařík, Michal and Průša, Richard and Kizek, René},
   article_number = {31},
   keywords = {matrix metalloproteinases; collagen; tissue inhibitors of matrix metalloproteinases; cysteine switch; zinc; metallothionein; tumour disease},
   language = {eng},
   issn = {0929-8673},
   journal = {Current Medicinal Chemistry},
   title = {Matrix metalloproteinases.},
   volume = {17},
   year = {2010}
}

TY  - JOUR
ID  - 921868
AU  - Zítka, Ondřej - Kukačka, Jiří - Křížková, Soňa - Húska, Dalibor - Adam, Vojtěch - Masařík, Michal - Průša, Richard - Kizek, René
PY  - 2010
TI  - Matrix metalloproteinases.
JF  - Current Medicinal Chemistry
VL  - 17
IS  - 31
SN  - 09298673
KW  - matrix metalloproteinases
KW  - collagen
KW  - tissue inhibitors of matrix metalloproteinases
KW  - cysteine switch
KW  - zinc
KW  - metallothionein
KW  - tumour disease
N2  - Matrix metalloproteinases (MMPs), also known as matrixins, belong to a group of zinc-dependent proteins, which are thought to play a central role in the breakdown of extracellular matrix. Collagen, elastin, gelatine and casein are major components cleaved by MMPs. The breakdown of these components is essential for many physiological processes such as embryonic development, morphogenesis, reproduction, and tissue resorption and remodelling. MMPs also participate in pathological processes such as arthritis, cancer, cardiovascular and neurological diseases. This review summarizes current knowledge regarding these proteins, their participation in physiological and pathophysiological roles, their involvement in activation and inhibition, and their interactions with other metal-binding proteins including metallothioneins.
ER  -

ZÍTKA, Ondřej; Jiří KUKAČKA; Soňa KŘÍŽKOVÁ; Dalibor HÚSKA; Vojtěch ADAM; Michal MASAŘÍK; Richard PRŮŠA a René KIZEK. Matrix metalloproteinases. \textit{Current Medicinal Chemistry}. 2010, roč.~17, č.~31, 18 s. ISSN~0929-8673.

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