Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A
template-based approach-Part 1.

J 2011

Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 1.

DWYER, Michael; Kamil PARUCH; Marc LABROLI; Carmen ALVAREZ; Kerry KEERTIKAR et. al.

Základní údaje

Originální název

Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 1.

Název česky

Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 1.

Autoři

DWYER, Michael (840 Spojené státy); Kamil PARUCH (203 Česká republika, garant, domácí); Marc LABROLI (840 Spojené státy); Carmen ALVAREZ (840 Spojené státy); Kerry KEERTIKAR (840 Spojené státy); Cory POKER (840 Spojené státy); Randall ROSSMAN (840 Spojené státy); Thierry FISCHMANN (840 Spojené státy); Jose DUCA (840 Spojené státy); Vincent MADISON (840 Spojené státy); David PARRY (840 Spojené státy); Nicole DAVIS (840 Spojené státy); Wolfgang SEGHEZZI (840 Spojené státy); Derek WISWELL (840 Spojené státy) a Timothy GUZI (840 Spojené státy)

Vydání

Bioorganic & Medicinal Chemistry Letters, Elsevier, 2011, 0960-894X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10401 Organic chemistry

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.554

Kód RIV

RIV/00216224:14310/11:00051795

Organizační jednotka

Přírodovědecká fakulta

UT WoS

000285544400096

Klíčová slova anglicky

Kinase CHK1 Pyrazolo[1 5-a]pyrimidine Template

Štítky

rivok, ZR

Změněno: 5. 3. 2012 11:19, Ing. Zdeňka Rašková

Anotace

V originále

The synthesis and hit-to-lead SAR development of a pyrazolo[1,5-a]pyrimidine hit 4 is described leading to a series of potent, selective CHK1 inhibitors such as compound 17r. In the Letter, the further utility of the pyrazolo[1,5-a]pyrimidine template for the development of potent, selective kinase inhibitors is detailed.

Citovat

DWYER, Michael; Kamil PARUCH; Marc LABROLI; Carmen ALVAREZ; Kerry KEERTIKAR; Cory POKER; Randall ROSSMAN; Thierry FISCHMANN; Jose DUCA; Vincent MADISON; David PARRY; Nicole DAVIS; Wolfgang SEGHEZZI; Derek WISWELL a Timothy GUZI. Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 1. Bioorganic & Medicinal Chemistry Letters. Elsevier, 2011, roč. 21, č. 1, s. 467-470. ISSN 0960-894X.

@article{923150,
   author = {Dwyer, Michael and Paruch, Kamil and Labroli, Marc and Alvarez, Carmen and Keertikar, Kerry and Poker, Cory and Rossman, Randall and Fischmann, Thierry and Duca, Jose and Madison, Vincent and Parry, David and Davis, Nicole and Seghezzi, Wolfgang and Wiswell, Derek and Guzi, Timothy},
   article_number = {1},
   keywords = {Kinase CHK1 Pyrazolo[1 5-a]pyrimidine Template},
   language = {eng},
   issn = {0960-894X},
   journal = {Bioorganic & Medicinal Chemistry Letters},
   title = {Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 1.},
   volume = {21},
   year = {2011}
}

TY  - JOUR
ID  - 923150
AU  - Dwyer, Michael - Paruch, Kamil - Labroli, Marc - Alvarez, Carmen - Keertikar, Kerry - Poker, Cory - Rossman, Randall - Fischmann, Thierry - Duca, Jose - Madison, Vincent - Parry, David - Davis, Nicole - Seghezzi, Wolfgang - Wiswell, Derek - Guzi, Timothy
PY  - 2011
TI  - Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 1.
JF  - Bioorganic & Medicinal Chemistry Letters
VL  - 21
IS  - 1
SP  - 467-470
EP  - 467-470
PB  - Elsevier
SN  - 0960894X
KW  - Kinase CHK1 Pyrazolo[1 5-a]pyrimidine Template
N2  - The synthesis and hit-to-lead SAR development of a pyrazolo[1,5-a]pyrimidine hit 4 is described leading to a series of potent, selective CHK1 inhibitors such as compound 17r. In the Letter, the further utility of the pyrazolo[1,5-a]pyrimidine template for the development of potent, selective kinase inhibitors is detailed.
ER  -

DWYER, Michael; Kamil PARUCH; Marc LABROLI; Carmen ALVAREZ; Kerry KEERTIKAR; Cory POKER; Randall ROSSMAN; Thierry FISCHMANN; Jose DUCA; Vincent MADISON; David PARRY; Nicole DAVIS; Wolfgang SEGHEZZI; Derek WISWELL a Timothy GUZI. Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 1. \textit{Bioorganic \&{} Medicinal Chemistry Letters}. Elsevier, 2011, roč.~21, č.~1, s.~467-470. ISSN~0960-894X.

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