| SLABÝ, Ondřej, Milana ŠACHLOVÁ, Markéta BEDNAŘÍKOVÁ, Pavel FABIAN, Marek SVOBODA, Simona VYTOPILOVÁ, Dalibor VALÍK a Rostislav VYZULA. Gene Expression of Somatostatin Receptor 4 Predicts Clinical Outcome of Patients with Metastatic Neuroendocrine Tumors Treated with Somatostatin Analogs. Cancer Biotherapy and Radiopharmaceuticals. Mary Ann Liebert, 2010, roč. 25, č. 2, s. 237-243. ISSN 1084-9785. Dostupné z: https://dx.doi.org/10.1089/cbr.2009.0708. |
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@article{923377,
author = {Slabý, Ondřej and Šachlová, Milana and Bednaříková, Markéta and Fabian, Pavel and Svoboda, Marek and Vytopilová, Simona and Valík, Dalibor and Vyzula, Rostislav},
article_number = {2},
doi = {http://dx.doi.org/10.1089/cbr.2009.0708},
keywords = {carcinoid; neuroendocrine tumors; prognosis; response prediction; somatostatin analogs; somatostatin receptors},
language = {eng},
issn = {1084-9785},
journal = {Cancer Biotherapy and Radiopharmaceuticals},
title = {Gene Expression of Somatostatin Receptor 4 Predicts Clinical Outcome of Patients with Metastatic Neuroendocrine Tumors Treated with Somatostatin Analogs},
volume = {25},
year = {2010}
}
TY - JOUR
ID - 923377
AU - Slabý, Ondřej - Šachlová, Milana - Bednaříková, Markéta - Fabian, Pavel - Svoboda, Marek - Vytopilová, Simona - Valík, Dalibor - Vyzula, Rostislav
PY - 2010
TI - Gene Expression of Somatostatin Receptor 4 Predicts Clinical Outcome of Patients with Metastatic Neuroendocrine Tumors Treated with Somatostatin Analogs
JF - Cancer Biotherapy and Radiopharmaceuticals
VL - 25
IS - 2
SP - 237-243
EP - 237-243
PB - Mary Ann Liebert
SN - 10849785
KW - carcinoid
KW - neuroendocrine tumors
KW - prognosis
KW - response prediction
KW - somatostatin analogs
KW - somatostatin receptors
N2 - Somatostatin analogs (SSA) are the standard diagnostic and treatment tools in the clinical management of patients with neuroendocrine tumors (NETs) expressing somatostatin receptors (SSTRs). Although symptomatic and biochemical control is obtained with SSA in the majority of functional NETs, antineoplastic effects of SSA are partial and of limited duration. The aim of this study was to quantify expression levels of five SSTR subtypes (SSTR1-SSTR5) and correlate them with the clinical outcomes of patients with NETs who underwent SSA therapy. The expression levels were analyzed using real-time polymerase chain reaction in a series of 22 metastatic NETs with a median time of 10 months on the SSA therapy (range 2-82 months). The median duration of disease stabilization in patients who developed progression (n=14) was 9 months (range 3-92 months). The median survival period for all patients was 44 months (range 3-175 months). According to RECIST criteria, one (5%) partial objective tumor response was obtained, disease stabilization was achieved in 10 (45%) patients, and progressive disease was observed in 11 (50%). Analysis of mRNA expression of the SSTR subtypes showed that SSTR2 and SSTR5 were expressed in all of the studied NETs; SSTR1 and SSTR4 in all but 3 tumors (86%); and SSTR3 in only 10 NETs (49%). Interestingly, our preliminary data suggest that only the levels of SSTR4, though it has the lowest affinity for SSA of all SSTR subtypes, were significantly associated with the stabilization of disease during SSA therapy ( p=0.0357). These levels correlated with time to progression ( p=0.0015) and overall survival ( p=0.0017) in NET patients.
ER -
SLABÝ, Ondřej, Milana ŠACHLOVÁ, Markéta BEDNAŘÍKOVÁ, Pavel FABIAN, Marek SVOBODA, Simona VYTOPILOVÁ, Dalibor VALÍK a Rostislav VYZULA. Gene Expression of Somatostatin Receptor 4 Predicts Clinical Outcome of Patients with Metastatic Neuroendocrine Tumors Treated with Somatostatin Analogs. \textit{Cancer Biotherapy and Radiopharmaceuticals}. Mary Ann Liebert, 2010, roč.~25, č.~2, s.~237-243. ISSN~1084-9785. Dostupné z: https://dx.doi.org/10.1089/cbr.2009.0708.
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