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@article{923433, author = {Kiran, S. and Cocco, P. and Mannetje, A. and Satta, G. and D'Andrea, I. and Becker, N. and de Sanjose, S. and Foretová, Lenka and Staines, A. and Kleefeld, S. and Maynadie, M. and Nieters, A. and Brennan, P. and Boffetta, P.}, article_location = {Philadelphia (USA)}, article_number = {6}, doi = {http://dx.doi.org/10.1097/EDE.0b013e3181f4cc0f}, keywords = {CHLOROHYDRIN PRODUCTION; PRODUCTION WORKERS; CANCER-MORTALITY; FOLLOW-UP; COHORT; EPILYMPH; UPDATE}, language = {eng}, issn = {1044-3983}, journal = {Epidemiology}, title = {Occupational exposure to ethylene oxide and risk of lymphoma}, volume = {21}, year = {2010} }
TY - JOUR ID - 923433 AU - Kiran, S. - Cocco, P. - Mannetje, A. - Satta, G. - D'Andrea, I. - Becker, N. - de Sanjose, S. - Foretová, Lenka - Staines, A. - Kleefeld, S. - Maynadie, M. - Nieters, A. - Brennan, P. - Boffetta, P. PY - 2010 TI - Occupational exposure to ethylene oxide and risk of lymphoma JF - Epidemiology VL - 21 IS - 6 SP - 905-910 EP - 905-910 PB - Lippincott Williams and Wilkins SN - 10443983 KW - CHLOROHYDRIN PRODUCTION KW - PRODUCTION WORKERS KW - CANCER-MORTALITY KW - FOLLOW-UP KW - COHORT KW - EPILYMPH KW - UPDATE N2 - Ethylene oxide, a high-volume commodity, is an established human carcinogen, although the relevant epidemiologic evidence is limited. Methods: We explored the association between occupational exposure to ethylene oxide and risk of lymphoma in a case-control study, including 2347 lymphoma cases first diagnosed in 1998-2004 and 2463 controls, from 6 European countries. The diagnosis of lymphoma was based on the 2001 World Health Organization Classification of lymphoma. Occupational exposure to ethylene oxide was retrospectively assessed by industrial hygienists and occupational physicians based on detailed self-reported information. We modeled risk of lymphoma with unconditional logistic regression analysis as a function of various exposure measures, adjusting for age, sex, and participating center. Results: Thirty-one cases and 27 controls (1.2% of the total study population) were defined as ever having been exposed to ethylene oxide (odds ratio = 1.3 [95% confidence interval [CI] = 0.7-2.1]). Lymphoma risk showed a 4.3-fold increase associated with medium-high frequency of exposure to ethylene oxide (95% CI = 1.4-13). Among major subtypes, chronic lymphocytic leukemia was consistently associated with ethylene oxide exposure, related in a dose-response manner to probability, frequency, and duration of exposure, as well as to cumulative exposure and (less definitively) with exposure intensity. ER -
KIRAN, S., P. COCCO, A. MANNETJE, G. SATTA, I. D'ANDREA, N. BECKER, S. DE SANJOSE, Lenka FORETOVÁ, A. STAINES, S. KLEEFELD, M. MAYNADIE, A. NIETERS, P. BRENNAN a P. BOFFETTA. Occupational exposure to ethylene oxide and risk of lymphoma. \textit{Epidemiology}. Philadelphia (USA): Lippincott Williams and Wilkins, 2010, roč.~21, č.~6, s.~905-910. ISSN~1044-3983. Dostupné z: https://dx.doi.org/10.1097/EDE.0b013e3181f4cc0f.
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